Abstract：
:DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from mutation during both DNA replication and transcription. This review describes the recent discoveries in this area. Potential mechanisms by which MMR safeguards actively transcribed genes are also discussed.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Huang Y,Li GMdoi
10.1016/j.dnarep.2018.08.010subject
Has Abstractpub_date
2018-11-01 00:00:00pages
82-86eissn
1568-7864issn
1568-7856pii
S1568-7864(18)30175-7journal_volume
71pub_type
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