Abstract：
:Breast cancer is the most common and significant cancers in females regarding the loss of life quality. Similar to other cancers, one of the etiologic factors in breast cancer is DNA damage. A plethora of molecules are responsible for sensing DNA damage and mediating actions which lead to DNA repair, senescence, cell cycle arrest and if damage is unbearable to apoptosis. In each of these, aberrations leading to unrepaired damage was resulted in uncontrolled proliferation and cancer. Another cellular function is autophagy defined as a process eliminating of unnecessary proteins in stress cases involved in pathogenesis of cancer. Knowing their role in cancer, scholars have tried to develop strategies in order to target DDR and autophagy. Further, the interactions of DDR and autophagy plus their regulatory role on each other have been focused simultaneously. The present review study has aimed to illustrate the importance of DDR and autophagy in breast cancer according to the related studies and uncover the relation between DDR and autophagy and its significance in breast cancer therapy.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Mirza-Aghazadeh-Attari M,Recio MJ,Darband SG,Kaviani M,Safa A,Mihanfar A,Sadighparvar S,Karimian A,Alemi F,Majidinia M,Yousefi Bdoi
10.1016/j.dnarep.2020.103032subject
Has Abstractpub_date
2020-12-17 00:00:00pages
103032eissn
1568-7864issn
1568-7856pii
S1568-7864(20)30292-5journal_volume
98pub_type
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