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Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability.

Abstract：

:MutT enzymes prevent DNA damage by hydrolysis of 8-oxodGTP, an oxidized substrate for DNA synthesis and antimutagenic, anticarcinogenic, and antineurodegenerative functions of MutT enzymes are well established. MutT has been found in almost all kingdoms of life, including many bacterial species, yeasts, plants and mammals. However, a Caenorhabditis elegans MutT homologue was not previously identified. Here, we demonstrate that NDX-4 exhibits both hallmarks of a MutT-type enzyme with an ability to hydrolyze 8-oxodGTP and suppress the Escherichia coli mutT mutator phenotype. Moreover, we show that NDX-4 contributes to genomic stability in vivo in C. elegans. Phenotypic analyses of an ndx-4 mutant reveal that loss of NDX-4 leads to upregulation of key stress responsive genes that likely compensate for the in vivo role of NDX-4 in protection against deleterious consequences of oxidative stress. This discovery will enable us to use this extremely robust genetic model for further research into the contribution of oxidative DNA damage to phenotypes associated with oxidative stress.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Arczewska KD,Baumeier C,Kassahun H,Sengupta T,Bjørås M,Kuśmierek JT,Nilsen H

doi

10.1016/j.dnarep.2010.10.009

subject

Has Abstract

pub_date

2011-02-07 00:00:00

pages

176-87

issue

2

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(10)00361-7

journal_volume

10

pub_type

杂志文章

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