Abstract:
:Like many other cellular processes, regulation of the DNA damage response (DDR) is regulated at different levels, ranging from transcriptional control to an array of distinct post-translational modifications. Involvement of ubiquitylation and the ubiquitin proteasome system in adjusting DDR are such protein modifications that were receiving increasing attention in the field. In this review we summarize and discuss a few recent key publications addressing the issue of DDR factor ubiquitylation, focusing on UV-induced DDR. We discuss the implications of these modifications to allow swift adaptation and regulation of genome surveillance factors.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Bergink S,Jaspers NG,Vermeulen Wdoi
10.1016/j.dnarep.2007.01.012subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1231-42issue
9eissn
1568-7864issn
1568-7856pii
S1568-7864(07)00028-6journal_volume
6pub_type
杂志文章,评审相关文献
DNA REPAIR文献大全abstract::Bacterial MutS2 proteins, consisting of functional domains for ATPase, DNA-binding, and nuclease activities, play roles in DNA recombination and repair. Here we observe a mechanism for generating MutS2 expression diversity in the human pathogen Helicobacter pylori, and identify a unique MutS2 domain responsible for sp...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2017.07.004
更新日期:2017-09-01 00:00:00
abstract::Despite detailed knowledge on the genetic network and biochemical properties of most of the nucleotide excision repair (NER) proteins, cell biological analysis has only recently made it possible to investigate the temporal and spatial organization of NER. In contrast to several other DNA damage response mechanisms tha...
journal_title:DNA repair
pub_type: 杂志文章,评审
doi:10.1016/j.dnarep.2011.04.015
更新日期:2011-07-15 00:00:00
abstract::p53 Binding protein 1 (53BP1) belongs to a family of evolutionarily conserved DNA damage checkpoint proteins with C-terminal BRCT domains and is most likely the human ortholog of the budding yeast Rad9 protein, the first cell cycle checkpoint protein to be described. 53BP1 localizes rapidly to sites of DNA double stra...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2004.03.017
更新日期:2004-08-01 00:00:00
abstract::Structure-prone DNA repeats are common components of genomic DNA in all kingdoms of life. In humans, these repeats are linked to genomic instabilities that result in various hereditary disorders, including many cancers. It has long been known that DNA repeats are not only highly polymorphic in length but can also caus...
journal_title:DNA repair
pub_type: 杂志文章,评审
doi:10.1016/j.dnarep.2015.04.020
更新日期:2015-08-01 00:00:00
abstract::Comparison of the clinical and cellular phenotypes of different genomic instability syndromes provides new insights into functional links in the complex network of the DNA damage response. A prominent example of this principle is provided by examination of three such disorders: ataxia-telangiectasia (A-T) caused by la...
journal_title:DNA repair
pub_type: 杂志文章,评审
doi:10.1016/j.dnarep.2004.04.009
更新日期:2004-08-01 00:00:00
abstract::Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We conclude the following: (a) slipped (hairpin) structures, cruciforms, triplexes, tetraplexes and i-motifs, and left-handed Z-DNA are formed in chromosomes and el...
journal_title:DNA repair
pub_type: 杂志文章,评审
doi:10.1016/j.dnarep.2006.05.032
更新日期:2006-09-08 00:00:00
abstract::Proteins that act on DNA, or are in close proximity to it, can become inadvertently crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs). DPCs are generated by different chemotherapeutics, environmental or endogenous sources of crosslinking agents, or by lesions on DNA that stall th...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2020.102924
更新日期:2020-10-01 00:00:00
abstract::Ribonucleotide reductase (RNR) is the enzyme critically responsible for the production of the 5'-deoxynucleoside-triphosphates (dNTPs), the direct precursors for DNA synthesis. The dNTP levels are tightly controlled to permit high efficiency and fidelity of DNA synthesis. Much of this control occurs at the level of th...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2012.02.001
更新日期:2012-05-01 00:00:00
abstract::Eukaryotic cells repair ultraviolet light (UV)- and chemical carcinogen-induced DNA strand-distorting damage through the nucleotide excision repair (NER) pathway. Concurrent activation of the DNA damage checkpoints is also required to arrest the cell cycle and allow time for NER action. Recent studies uncovered critic...
journal_title:DNA repair
pub_type: 杂志文章,评审
doi:10.1016/j.dnarep.2009.01.011
更新日期:2009-04-05 00:00:00
abstract::Brh2, the BRCA2 ortholog in the fungus Ustilago maydis, harbors two different DNA-binding domains, one located in the N-terminal region and the other located in the C-terminal region. Here we were interested in comparing the biochemical properties of Brh2 fragments, Brh2(NT) and Brh2(CT), respectively, harboring the t...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2014.07.013
更新日期:2014-10-01 00:00:00
abstract::From bacteria to humans, ancient stress responses enable organisms to contend with damage to both the genome and the proteome. These pathways have long been viewed as fundamentally separate responses. Yet recent discoveries from multiple fields have revealed surprising links between the two. Many DNA-damaging agents a...
journal_title:DNA repair
pub_type: 杂志文章,评审
doi:10.1016/j.dnarep.2018.08.004
更新日期:2018-11-01 00:00:00
abstract::Thymidylate deprivation brings about "thymineless death" in prokaryotes and eukaryotes. Although the precise mechanism for thymineless death has remained elusive, inhibition of the enzyme thymidylate synthase (TS), which catalyzes the de novo synthesis of TMP, has served for many years as a basis for chemotherapeutic ...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2008.06.006
更新日期:2008-10-01 00:00:00
abstract::Loss of telomeres stability is a hallmark of cancer cells. Exposed telomeres are prone to aberrant end-joining reactions leading to chromosomal fusions and translocations. Human telomeres contain repeated TTAGGG elements, in which the 3' exposed strand may adopt a G-quadruplex (G4) structure. The guanine-rich regions ...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2018.11.010
更新日期:2019-01-01 00:00:00
abstract::UVB radiation results in the formation of potentially mutagenic photoproducts in the DNA of epidermal skin cells. In vitro approaches have demonstrated that the nucleotide excision repair (NER) machinery removes UV photoproducts from DNA in the form of small (∼30-nt-long), excised, damage-containing DNA oligonucleotid...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2019.102766
更新日期:2020-02-01 00:00:00
abstract::Multiple DNA polymerases participate in somatic hypermutation of immunoglobulin (Ig) genes. Mutations at A/T are largely dependent on DNA polymerase eta (POLH) whereas mutations at C/G appear to be generated by several DNA polymerases. We have previously shown that mice expressing a catalytically inactive POLQ (Polq-i...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2006.06.006
更新日期:2006-11-08 00:00:00
abstract::The dnaN gene in eubacteria is an essential gene that encodes the beta subunit of replicative DNA polymerase. Nearly all eubacterial genomes sequenced to date predict a single copy of the dnaN gene in a well-conserved neighboring gene context. However, 19 genomes out of 348 scanned, including Bacillus anthracis, Bacil...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2007.10.003
更新日期:2008-03-01 00:00:00
abstract::Proteins responsible for the integrity of the genome are often used targets in drug therapies against various diseases. The inhibitors of these proteins are also important to study the pathways in genome integrity maintenance. A prominent example is Ugi, a well known cross-species inhibitor protein of the enzyme uraci...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2015.03.005
更新日期:2015-06-01 00:00:00
abstract::The DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase (MGMT) can confer resistance to the cancer chemotherapeutic effects of the class of DNA damaging drugs generally referred to as the O(6)-alkylating agents. Inactivation of MGMT is thus a practical approach to improving the efficacy of such agents. An accou...
journal_title:DNA repair
pub_type: 历史文章,杂志文章
doi:10.1016/j.dnarep.2007.03.015
更新日期:2007-08-01 00:00:00
abstract::DNA interstrand crosslinks (ICLs) are highly toxic lesions that covalently link both strands of DNA and distort the DNA helix. Crosslinking agents have been shown to stall DNA replication and failure to repair ICL lesions before encountered by replication forks may induce severe DNA damage. Most knowledge of the ICL r...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2012.09.010
更新日期:2012-12-01 00:00:00
abstract::Plant mitochondrial and chloroplast genomes encode essential proteins for oxidative phosphorylation and photosynthesis. For proper cellular function, plant organelles must ensure genome integrity. Although plant organelles repair damaged DNA using the multi-enzyme Base Excision Repair (BER) pathway, the details of thi...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2018.02.010
更新日期:2018-05-01 00:00:00
abstract::Cadmium (Cd(2+)) is a ubiquitous environmental pollutant and human carcinogen. The molecular basis of its toxicity remains unclear. Here, to identify the landscape of genes and cell functions involved in cadmium resistance, we have screened the Saccharomyces cerevisiae deletion collection for mutants sensitive to cadm...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2008.04.005
更新日期:2008-08-02 00:00:00
abstract::The human RAD51 recombinase possesses DNA pairing and strand exchange activities that are essential for the error-free, homology-directed repair of DNA double-strand breaks. The recombination activities of RAD51 are activated upon its assembly into presynaptic filaments on single-stranded DNA at resected DSB ends. Def...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2017.10.008
更新日期:2017-12-01 00:00:00
abstract::Mice defective for the Polk gene, which encodes DNA polymerase kappa, are viable and do not manifest obvious phenotypes. The present studies document a spontaneous mutator phenotype in Polk(-/-) mice. The initial indication of enhanced spontaneous mutations in these mice came from the serendipitous observation of a po...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2009.09.003
更新日期:2009-12-03 00:00:00
abstract::8-Oxoguanine (8-oxoG) is a major oxidative lesion produced in DNA by normal cellular metabolism or after exposure to exogenous sources such as ionizing radiation. Persistence of this lesion in DNA causes G to T transversions, with deleterious consequences for the cell. As a result, several repair processes have evolve...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2004.01.003
更新日期:2004-05-04 00:00:00
abstract::Xeroderma pigmentosum (XP) is a genetic disorder associated with defects in nucleotide excision repair, a pathway that eliminates a wide variety of helix-distorting DNA lesions, including ultraviolet-induced pyrimidine dimers. In addition to skin diseases in sun-exposed areas, approximately 25% of XP patients develop ...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2019.04.004
更新日期:2019-08-01 00:00:00
abstract::Base excision repair (BER) of damaged or inappropriate bases in DNA has been reported to take place by single nucleotide insertion or through incorporation of several nucleotides, termed short-patch and long-patch repair, respectively. We found that extracts from proliferating and non-proliferating cells both had capa...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2009.04.002
更新日期:2009-07-04 00:00:00
abstract::TFIIH is a multiprotein complex that has a central role in the RNA pol II mediated transcription, in DNA repair and in the control of the cell cycle. Mutations in some components of TFIIH are associated with three hereditary human syndromes: xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (T...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/s1568-7864(02)00012-5
更新日期:2002-05-30 00:00:00
abstract::Nucleotide excision repair (NER) is a DNA repair pathway, which eliminates various types of helix-distorting DNA damage including some forms of oxidative damage and UV-induced photoproducts. To understand why patients with NER-defective disorders develop progressive neurological abnormalities, we investigated NER capa...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2006.12.006
更新日期:2007-05-01 00:00:00
abstract::The MutS2 homologues have been found widespread in most prokaryotes, which are involved in DNA repair and reactive oxygen species detoxification. The C-terminal small mutS-related (Smr) domain is critical for its endonucleolytic activity. However, the detailed catalytic mechanism is still unclear. In this study, we fi...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2014.04.012
更新日期:2014-09-01 00:00:00
abstract::Accumulation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) in DNA is associated with mutagenesis and cell death. Little attention has been given to the biological significance of 8-oxo-dG accumulation in cardiovascular tissues during the different stage of hypertension and its prevention. We thus investigated the ...
journal_title:DNA repair
pub_type: 杂志文章
doi:10.1016/j.dnarep.2007.01.003
更新日期:2007-06-01 00:00:00