abstract：:The DNA damage response (DDR) pathway's primary purpose is to maintain the genome structure's integrity and stability. A great deal of effort has done to understand the exact molecular mechanisms of non-coding RNAs, such as lncRNA, miRNAs, and circRNAs, in distinct cellular and genomic processes and cancer progression...

journal_title：DNA repair

authors： Malakoti F,Alemi F,Younesi S,Majidinia M,Yousefi B,Morovat P,Khelghati N,Maleki M,Karimian A,Asemi Z

更新日期：2021-01-07 00:00:00

abstract：:Nucleotide excision repair (NER) stands out among other DNA repair systems for its ability to process a diverse set of unrelated DNA lesions. In bacteria, NER damage detection is orchestrated by the UvrA and UvrB proteins, which form the UvrA2-UvrB2 (UvrAB) damage sensing complex. The highly versatile damage recogniti...

journal_title：DNA repair

authors： Kraithong T,Sucharitakul J,Buranachai C,Jeruzalmi D,Chaiyen P,Pakotiprapha D

更新日期：2021-01-01 00:00:00

abstract：:Breast cancer is the most common and significant cancers in females regarding the loss of life quality. Similar to other cancers, one of the etiologic factors in breast cancer is DNA damage. A plethora of molecules are responsible for sensing DNA damage and mediating actions which lead to DNA repair, senescence, cell ...

journal_title：DNA repair

authors： Mirza-Aghazadeh-Attari M,Recio MJ,Darband SG,Kaviani M,Safa A,Mihanfar A,Sadighparvar S,Karimian A,Alemi F,Majidinia M,Yousefi B

更新日期：2020-12-17 00:00:00

abstract：:Human cancers frequently harbour mutations in DNA repair genes, rendering the use of DNA damaging agents as an effective therapeutic intervention. As therapy-resistant cells often arise, it is important to better understand the molecular pathways that drive resistance in order to facilitate the eventual targeting of s...

journal_title：DNA repair

authors： Vydzhak O,Bender K,Klermund J,Busch A,Reimann S,Luke B

更新日期：2020-11-01 00:00:00

abstract：:Genome integrity is constantly challenged by exogenous and endogenous insults, and mutations are associated with inherited disease and cancer. Here we summarize recent studies that utilized C. elegans whole genome next generation sequencing to experimentally determine mutational signatures associated with mutagen expo...

journal_title：DNA repair

authors： Meier B,Volkova NV,Gerstung M,Gartner A

更新日期：2020-11-01 00:00:00

abstract：:Proteins that act on DNA, or are in close proximity to it, can become inadvertently crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs). DPCs are generated by different chemotherapeutics, environmental or endogenous sources of crosslinking agents, or by lesions on DNA that stall th...

journal_title：DNA repair

authors： Kühbacher U,Duxin JP

更新日期：2020-10-01 00:00:00

abstract：:Mammalian cells possess multiple closely related SWI/SNF chromatin remodelling complexes. These complexes have been implicated in the cellular response to DNA double strand breaks (DSBs). Evidence suggests that SWI/SNF complexes contribute to successful repair via both the homologous recombination and non-homologous e...

journal_title：DNA repair

authors： Harrod A,Lane KA,Downs JA

更新日期：2020-09-01 00:00:00

abstract：:With the publication of the first paper describing the biochemical properties of DNA polymerase iota (polɩ), the question immediately arose as to why cells harbor such a low-fidelity enzyme which often violates the Watson-Crick base pairing rules? Yet 20 years after its discovery, the cellular function of polɩ remains...

journal_title：DNA repair

authors： Vaisman A,Woodgate R

更新日期：2020-09-01 00:00:00

abstract：:Endonuclease III (EndoIII) is nearly ubiquitous in all three domains of life. EndoIII family proteins exhibit a bifunctional (glycosylase/lyase) activity on oxidative/saturated pyrimidine bases, such as thymine glycol. Previous studies on EndoIII homologs have reported the presence of important residues involved in su...

journal_title：DNA repair

authors： Shiraishi M,Mizutani K,Yamamoto J,Iwai S

更新日期：2020-06-01 00:00:00

abstract：:Human papillomavirus (HPV) is associated with the development of head and neck squamous cell carcinomas (HNSC). Cisplatin is used to treat HNSC and induces DNA adducts including interstrand crosslinks (ICLs). Previous reports have shown that HPV positive HNSC patients respond better to cisplatin therapy. Our previous ...

journal_title：DNA repair

authors： Conner KL,Shaik AN,Ekinci E,Kim S,Ruterbusch JJ,Cote ML,Patrick SM

更新日期：2020-03-01 00:00:00

abstract：:UVB radiation results in the formation of potentially mutagenic photoproducts in the DNA of epidermal skin cells. In vitro approaches have demonstrated that the nucleotide excision repair (NER) machinery removes UV photoproducts from DNA in the form of small (∼30-nt-long), excised, damage-containing DNA oligonucleotid...

journal_title：DNA repair

authors： Choi JH,Han S,Kemp MG

更新日期：2020-02-01 00:00:00

abstract：:The integrity of cellular genome is continuously challenged by endogenous and exogenous DNA damaging agents. If DNA damage is not removed in a timely fashion the replisome may stall at DNA lesions, causing fork collapse and genetic instability. Base excision DNA repair (BER) is the most important pathway for the remov...

journal_title：DNA repair

authors： Jaiswal AS,Williamson EA,Srinivasan G,Kong K,Lomelino CL,McKenna R,Walter C,Sung P,Narayan S,Hromas R

更新日期：2020-02-01 00:00:00

abstract：:Reactive oxygen species drive the oxidation of guanine to 8-oxoguanine (8oxoG), which threatens genome integrity. The repair of 8oxoG is carried out by base excision repair enzymes in Bacteria and Eukarya, however, little is known about archaeal 8oxoG repair. This study identifies a member of the Ogg-subfamily archaea...

journal_title：DNA repair

authors： Gehring AM,Zatopek KM,Burkhart BW,Potapov V,Santangelo TJ,Gardner AF

更新日期：2020-02-01 00:00:00

abstract：:By combining mutations in DNA repair genes, important and unexpected interactions between different repair pathways can be discovered. In this study, we identified a novel link between mismatch repair (MMR) genes and postreplication repair (PRR) in Saccharomyces cerevisiae. Strains lacking Rad5 (HLTF in mammals), a pr...

journal_title：DNA repair

authors： Berg IL,Persson JO,Åström SU

更新日期：2020-01-01 00:00:00

abstract：:Mitochondria are membrane-bound organelles found in eukaryotic cells where they generate energy through the respiratory chain. They contain their own genome that encodes genes critical to the mitochondrial function, but most of their protein content is synthetized from nuclear encoded genes. Damages to the mtDNA can c...

journal_title：DNA repair

authors： Bernal M,Yang X,Lisby M,Mazón G

更新日期：2019-10-01 00:00:00

abstract：:The human gene that encodes XRCC1 was cloned nearly thirty years ago but experimental analysis of this fascinating protein is still unveiling new insights into the DNA damage response. XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) inclu...

journal_title：DNA repair

authors： Caldecott KW

更新日期：2019-09-01 00:00:00

abstract：:Conflicts between replication and transcription can have life-threatening consequences. RNA polymerase (RNAP) is the major impediment to replication progression, and its efficient removal from DNA should mitigate the consequences of collisions with replication. Cells have various proteins that can resolve conflicts by...

journal_title：DNA repair

authors： Ragheb M,Merrikh H

更新日期：2019-09-01 00:00:00

abstract：:In both replicating and non-replicating cells, the maintenance of genomic stability is of utmost importance. Dividing cells can repair DNA damage during cell division, tolerate the damage by employing potentially mutagenic DNA polymerases or die via apoptosis. However, the options for accurate DNA repair are more limi...

journal_title：DNA repair

authors： Abugable AA,Morris JLM,Palminha NM,Zaksauskaite R,Ray S,El-Khamisy SF

更新日期：2019-09-01 00:00:00

abstract：:Xeroderma pigmentosum (XP) is a genetic disorder associated with defects in nucleotide excision repair, a pathway that eliminates a wide variety of helix-distorting DNA lesions, including ultraviolet-induced pyrimidine dimers. In addition to skin diseases in sun-exposed areas, approximately 25% of XP patients develop ...

journal_title：DNA repair

authors： Mori T,Nakane H,Iwamoto T,Krokidis MG,Chatgilialoglu C,Tanaka K,Kaidoh T,Hasegawa M,Sugiura S

更新日期：2019-08-01 00:00:00

abstract：:Cellular DNA is constantly challenged by damage-inducing factors derived from exogenous or endogenous sources. Thus, to protect against DNA damage, cells have evolved complex and finely regulated mechanisms collectively known as DNA-damage response (DDR). However, DNA repair in eukaryotes does not occur merely in nake...

journal_title：DNA repair

authors： Lagunas-Rangel FA

更新日期：2019-08-01 00:00:00

abstract：:RAre DAmage and Repair sequencing (RADAR-seq) is a highly adaptable sequencing method that enables the identification and detection of rare DNA damage events for a wide variety of DNA lesions at single-molecule resolution on a genome-wide scale. In RADAR-seq, DNA lesions are replaced with a patch of modified bases tha...

journal_title：DNA repair

authors： Zatopek KM,Potapov V,Maduzia LL,Alpaslan E,Chen L,Evans TC Jr,Ong JL,Ettwiller LM,Gardner AF

更新日期：2019-08-01 00:00:00

abstract：:GLI1 is one of three transcription factors (GLI1, GLI2 and GLI3) that mediate the Hedgehog signal transduction pathway and play important roles in normal development. GLI1 and GLI2 form a positive-feedback loop and function as human oncogenes. The mouse and human GLI1 genes have untranslated 5' exons and large introns...

journal_title：DNA repair

authors： Taylor R,Long J,Yoon JW,Childs R,Sylvestersen KB,Nielsen ML,Leong KF,Iannaccone S,Walterhouse DO,Robbins DJ,Iannaccone P

更新日期：2019-07-01 00:00:00

abstract：:In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage. We review difference...

journal_title：DNA repair

authors： Silva E,Ideker T

更新日期：2019-07-01 00:00:00

abstract：:Bacterial RarA is thought to play crucial roles in the cellular response to blocked replication forks. We show that lack of Bacillus subtilis RarA renders cells very sensitive to H2O2, but not to methyl methane sulfonate or 4-nitroquinoline-1-oxide. RarA is epistatic to RecA in response to DNA damage. Inactivation of ...

journal_title：DNA repair

authors： Romero H,Torres R,Hernández-Tamayo R,Carrasco B,Ayora S,Graumann PL,Alonso JC

更新日期：2019-06-01 00:00:00

abstract：:Nucleotide excision repair (NER) is a versatile system that deals with various bulky and helix-distorting DNA lesions caused by UV and environmental mutagens. Based on how lesion recognition occurs, NER has been separated into global genome repair (GGR) and transcription-coupled repair (TCR). The yeast Rad7-Rad16 comp...

journal_title：DNA repair

authors： Liu L,Huo Y,Li J,Jiang T

更新日期：2019-05-01 00:00:00

abstract：:Reactive oxygen and nitrogen species (RONS) are formed as byproducts of many endogenous cellular processes, in response to infections, and upon exposure to various environmental factors. An increase in RONS can saturate the antioxidation system and leads to oxidative stress. Consequently, macromolecules are targeted f...

journal_title：DNA repair

authors： Alnajjar KS,Sweasy JB

更新日期：2019-04-01 00:00:00

abstract：:DNA fiber fluorography is widely employed to study the kinetics of DNA replication, but the usefulness of this approach has been limited by the lack of freely-available automated analysis tools. Quantification of DNA fibers usually relies on manual examination of immunofluorescence microscopy images, which is laboriou...

journal_title：DNA repair

authors： Ghesquière P,Elsherbiny A,Fortier E,McQuaid M,Mazzaferri J,Bélanger F,Cheriet F,Drobetsky E,Wurtele H,Costantino S

更新日期：2019-02-01 00:00:00

abstract：:Expansion of a CGG-repeat tract in the 5' UTR of FMR1 is responsible for the Fragile X-related disorders (FXDs), FXTAS, FXPOI and FXS. Previous work in a mouse model of these disorders has implicated proteins in the base excision and the mismatch repair (MMR) pathways in the expansion mechanism. However, the precise r...

journal_title：DNA repair

authors： Gazy I,Hayward B,Potapova S,Zhao X,Usdin K

更新日期：2019-02-01 00:00:00

abstract：:DNA mismatch repair is an evolutionarily conserved repair pathway that corrects replication errors. In most prokaryotes and all eukaryotes, the mismatch repair protein MutL is a sequence-unspecific endonuclease that nicks the newly synthesized strand and marks it for repair. Although the sequence of the endonuclease d...

journal_title：DNA repair

authors： Liu L,Ortiz Castro MC,Rodríguez González J,Pillon MC,Guarné A

更新日期：2019-01-01 00:00:00

abstract：:Loss of telomeres stability is a hallmark of cancer cells. Exposed telomeres are prone to aberrant end-joining reactions leading to chromosomal fusions and translocations. Human telomeres contain repeated TTAGGG elements, in which the 3' exposed strand may adopt a G-quadruplex (G4) structure. The guanine-rich regions ...

journal_title：DNA repair

authors： Burra S,Marasco D,Malfatti MC,Antoniali G,Virgilio A,Esposito V,Demple B,Galeone A,Tell G

更新日期：2019-01-01 00:00:00

abstract：:DNA-PKcs deficiency has been studied in numerous animal models and cell culture systems. In previous studies of kinase inactivating mutations in cell culture systems, ablation of DNA-PK's catalytic activity results in a cell phenotype that is virtually indistinguishable from that ascribed to complete loss of the enzym...

journal_title：DNA repair

authors： Neal JA,Meek K

更新日期：2019-01-01 00:00:00

abstract：:Flaws in the DNA replication process have emerged as a leading driver of genome instability in human diseases. Alteration to replication fork progression is a defining feature of replication stress and the consequent failure to maintain fork integrity and complete genome duplication within a single round of S-phase co...

journal_title：DNA repair

authors： Ait Saada A,Lambert SAE,Carr AM

更新日期：2018-11-01 00:00:00

abstract：:From bacteria to humans, ancient stress responses enable organisms to contend with damage to both the genome and the proteome. These pathways have long been viewed as fundamentally separate responses. Yet recent discoveries from multiple fields have revealed surprising links between the two. Many DNA-damaging agents a...

journal_title：DNA repair

authors： Xie JL,Jarosz DF

更新日期：2018-11-01 00:00:00

abstract：:Early work from about two decades ago implicated DNA double-strand break (DSB) formation and repair in neuronal development. Findings emerging from recent studies of DSBs in proliferating neural progenitors and in mature, non-dividing neurons suggest important roles of DSBs in brain physiology, aging, cancer, psychiat...

journal_title：DNA repair

authors： Alt FW,Schwer B

更新日期：2018-11-01 00:00:00

abstract：:In a multicellular organism, somatic mutations represent a permanent record of the past chemical and biochemical perturbations experienced by a cell in its local microenvironment. Akin to a perpetual recording device, with every replication, genomic DNA accumulates mutations in patterns that reflect: i) the sequence c...

journal_title：DNA repair

authors： Fedeles BI,Essigmann JM

更新日期：2018-11-01 00:00:00

abstract：:Before a deleterious DNA lesion can be replaced with its undamaged counterpart, the lesion must first be removed from the genome. This process of removing and replacing DNA lesions is accomplished by the careful coordination of several protein factors during DNA repair. One such factor is the multifunctional enzyme hu...

journal_title：DNA repair

authors： Whitaker AM,Freudenthal BD

更新日期：2018-11-01 00:00:00

abstract：:DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from m...

journal_title：DNA repair

authors： Huang Y,Li GM

更新日期：2018-11-01 00:00:00

abstract：:Plant mitochondrial and chloroplast genomes encode essential proteins for oxidative phosphorylation and photosynthesis. For proper cellular function, plant organelles must ensure genome integrity. Although plant organelles repair damaged DNA using the multi-enzyme Base Excision Repair (BER) pathway, the details of thi...

journal_title：DNA repair

authors： Trasviña-Arenas CH,Baruch-Torres N,Cordoba-Andrade FJ,Ayala-García VM,García-Medel PL,Díaz-Quezada C,Peralta-Castro A,Ordaz-Ortiz JJ,Brieba LG

更新日期：2018-05-01 00:00:00

abstract：:Base excision repair (BER) is a major defense pathway against spontaneous DNA damage. This multistep process is initiated by DNA glycosylases that recognise and excise the damaged base, and proceeds by the concerted action of additional proteins that perform incision of the abasic site, gap filling and ligation. BER h...

journal_title：DNA repair

authors： Morales-Ruiz T,Romero-Valenzuela ÁC,Vázquez-Grande VM,Roldán-Arjona T,Ariza RR,Córdoba-Cañero D

更新日期：2018-05-01 00:00:00

abstract：:Deamination of adenine can occur spontaneously under physiological conditions to generate the highly mutagenic lesion, deoxyinosine (hypoxanthine deoxyribonucleotide, dI). In DNA, dI preferably pairs with cytosine rather than thymine and results in A:T to G:C transition mutations after DNA replication. The deamination...

journal_title：DNA repair

authors： Su KY,Lin LI,Goodman SD,Yen RS,Wu CY,Chang WC,Yang YC,Cheng WC,Fang WH

更新日期：2018-04-01 00:00:00