Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases.

abstract：:Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of genomic integrity. Recently, in addition to phosphorylation, other post-translational modifications such as ubiquitylation and SUMOylation have emerged as impor...

journal_title：DNA repair

authors： Zlatanou A,Stewart GS

更新日期：2010-05-04 00:00:00

abstract：:Humans have five members of the well conserved RecQ helicase family: RecQ1, Bloom syndrome protein (BLM), Werner syndrome protein (WRN), RecQ4, and RecQ5, which are all known for their roles in maintaining genome stability. BLM, WRN, and RecQ4 are associated with premature aging and cancer predisposition. Of the three...

journal_title：DNA repair

authors： Rossi ML,Ghosh AK,Kulikowicz T,Croteau DL,Bohr VA

更新日期：2010-07-01 00:00:00

abstract：:Current data indicate that clustered DNA damage generated by ionizing radiation contains 2-5 damages within 20 bps. The complexity of clustered damage is also believed to increase as the linear energy transfer of the radiation increases. Complex lesions are therefore biologically relevant especially with the use of ca...

journal_title：DNA repair

authors： Malyarchuk S,Castore R,Harrison L

更新日期：2009-12-03 00:00:00

abstract：:The accuracy of DNA synthesis depends on the accuracy of the polymerase as well as the quality and concentration(s) of the available 5'-deoxynucleoside-triphosphate DNA precursors (dNTPs). The relationships between dNTPs and error rates have been studied in vitro, but only limited insights exist into these correlation...

journal_title：DNA repair

authors： Schaaper RM,Mathews CK

更新日期：2013-01-01 00:00:00

abstract：:I was born in January, 1921 and was fortunate in working for a research organization that had no fixed retirement age. I was permitted to continue Science as long as there were some resources to support research that had some relevance to the organization's goals. A number of projects on which I worked were continuati...

journal_title：DNA repair

authors： Setlow RB

更新日期：2004-04-01 00:00:00

abstract：:UVB radiation results in the formation of potentially mutagenic photoproducts in the DNA of epidermal skin cells. In vitro approaches have demonstrated that the nucleotide excision repair (NER) machinery removes UV photoproducts from DNA in the form of small (∼30-nt-long), excised, damage-containing DNA oligonucleotid...

journal_title：DNA repair

authors： Choi JH,Han S,Kemp MG

更新日期：2020-02-01 00:00:00

abstract：:RECQL5 is one of the five human RecQ helicases, involved in the maintenance of genomic integrity. While much insight has been gained into the function of the Werner (WRN) and Bloom syndrome proteins (BLM), little is known about RECQL5. We have analyzed the recruitment and retention dynamics of RECQL5 at laser-induced ...

journal_title：DNA repair

authors： Popuri V,Ramamoorthy M,Tadokoro T,Singh DK,Karmakar P,Croteau DL,Bohr VA

更新日期：2012-07-01 00:00:00

abstract：:Primary human somatic cells grown in culture divide a finite number of times, exhibiting progressive changes in metabolism and morphology before cessation of cycling. This telomere-initiated cellular senescence occurs because cells have halted production of telomerase, a DNA polymerase required for stabilization of ch...

journal_title：DNA repair

authors： Becerra SC,Thambugala HT,Erickson AR,Lee CK,Lewis LK

更新日期：2012-01-02 00:00:00

abstract：:Misalignment of a nascent strand and the use of an alternative template during DNA replication, a process termed "template-switching", can give rise to frequent mutations and genetic rearrangements. Mutational hotspots are frequently found associated with imperfect inverted repeats ("quasipalindromes" or "QPs") in man...

journal_title：DNA repair

authors： Laranjo LT,Gross SJ,Zeiger DM,Lovett ST

更新日期：2017-09-01 00:00:00

abstract：:Radiation-induced complex double-strand breaks (DSBs) characterised by base lesions, abasic sites or single-strand breaks in close proximity to the break termini, are believed to be a major cause of the biological effects of ionising radiation exposure. It has been hypothesised that complex DSBs pose problems for the ...

journal_title：DNA repair

authors： Dobbs TA,Palmer P,Maniou Z,Lomax ME,O'Neill P

更新日期：2008-08-02 00:00:00

abstract：:The RAD6/RAD18 heterodimer promotes translesion synthesis via the monoubiquitination of the DNA sliding clamp, PCNA. In S. cerevisiae, a second complex, UBC13/MMS2/RAD5, can extend this single ubiquitin with a non-canonical lysine 63-linked chain. This polyubiquitination step is required for an error-free mode of bypa...

journal_title：DNA repair

authors： Simpson LJ,Sale JE

更新日期：2005-04-04 00:00:00

abstract：:TFIIH is a multiprotein complex that has a central role in the RNA pol II mediated transcription, in DNA repair and in the control of the cell cycle. Mutations in some components of TFIIH are associated with three hereditary human syndromes: xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (T...

journal_title：DNA repair

authors： Castro J,Merino C,Zurita M

更新日期：2002-05-30 00:00:00

abstract：:The DNA polymerase beta (Pol beta) null background renders mouse embryonic fibroblast (MEF) cells base excision repair deficient and hyper-mutagenic upon treatment with the monofunctional alkylating agent, methyl methanesulfonate (MMS). This effect involves an increase in all types of base substitutions, with a modest...

journal_title：DNA repair

authors： Poltoratsky V,Horton JK,Prasad R,Wilson SH

更新日期：2005-09-28 00:00:00

abstract：:Eukaryotic genomes are especially vulnerable to DNA damage during the S phase of the cell cycle, when chromosomes must be duplicated. The stability of DNA replication forks is critical to achieve faithful chromosome replication and is severely compromised when forks encounter DNA lesions. To maintain genome integrity,...

journal_title：DNA repair

authors： Vázquez MV,Rojas V,Tercero JA

更新日期：2008-10-01 00:00:00

abstract：:Reactive oxygen and nitrogen species (RONS) are formed as byproducts of many endogenous cellular processes, in response to infections, and upon exposure to various environmental factors. An increase in RONS can saturate the antioxidation system and leads to oxidative stress. Consequently, macromolecules are targeted f...

journal_title：DNA repair

authors： Alnajjar KS,Sweasy JB

更新日期：2019-04-01 00:00:00

abstract：:Prediabetes is the preclinical stage of type 2 diabetes mellitus (T2DM) with intermediate state of hyperglycemia. Hyperglycemia results in a state of oxidative stress, which may contribute to the production of insulin resistance, β-cell dysfunction and long-term complications of diabetes. Novel approaches are required...

journal_title：DNA repair

authors： Kant M,Akış M,Çalan M,Arkan T,Bayraktar F,Dizdaroglu M,İşlekel H

更新日期：2016-12-01 00:00:00

abstract：:A recently discovered group of novel polymerases are characterized by significantly reduced fidelity of DNA synthesis in vitro. This feature is consistent with the relaxed fidelity required for the replicative bypass of various types of base damage that frequently block high fidelity replicative polymerases. The prese...

journal_title：DNA repair

authors： Velasco-Miguel S,Richardson JA,Gerlach VL,Lai WC,Gao T,Russell LD,Hladik CL,White CL,Friedberg EC

更新日期：2003-01-02 00:00:00

abstract：:The dnaN gene in eubacteria is an essential gene that encodes the beta subunit of replicative DNA polymerase. Nearly all eubacterial genomes sequenced to date predict a single copy of the dnaN gene in a well-conserved neighboring gene context. However, 19 genomes out of 348 scanned, including Bacillus anthracis, Bacil...

journal_title：DNA repair

authors： Yang H,Miller JH

更新日期：2008-03-01 00:00:00

abstract：:Chk1 is a protein kinase that acts as a key signal transducer within the complex network responsible of the cellular response to different DNA damages. It is a conserved element along the eukaryotic kingdom, together with a second checkpoint kinase, called Chk2/Rad53. In fact, all organisms studied so far carried at l...

journal_title：DNA repair

authors： Pérez-Martín J

更新日期：2009-06-04 00:00:00

abstract：:Nucleotide excision repair (NER) is a DNA repair pathway, which eliminates various types of helix-distorting DNA damage including some forms of oxidative damage and UV-induced photoproducts. To understand why patients with NER-defective disorders develop progressive neurological abnormalities, we investigated NER capa...

journal_title：DNA repair

authors： Yamamoto A,Nakamura Y,Kobayashi N,Iwamoto T,Yoshioka A,Kuniyasu H,Kishimoto T,Mori T

更新日期：2007-05-01 00:00:00

abstract：:Proteins that act on DNA, or are in close proximity to it, can become inadvertently crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs). DPCs are generated by different chemotherapeutics, environmental or endogenous sources of crosslinking agents, or by lesions on DNA that stall th...

journal_title：DNA repair

authors： Kühbacher U,Duxin JP

更新日期：2020-10-01 00:00:00

abstract：:Budding yeast SGS1 and the human Bloom's syndrome (BS) gene, BLM, are homologues of the Escherichia coli recQ. Cells derived from BS patients are characterized by a dramatic increase in sister chromatid exchange (SCE). We previously reported that budding yeast cells deficient in SGS1 showed an increase in the frequenc...

journal_title：DNA repair

authors： Onoda F,Seki M,Wang W,Enomoto T

更新日期：2004-10-05 00:00:00

abstract：:Both UVB radiation and DNA-breaking agents were previously reported to kill Arabidopsis stem cells. We demonstrate that death induced by UVB or by ionizing radiation (IR) requires Suppressor of Gamma Response 1 (SOG1), a transcription factor already found to govern many responses to these agents in Arabidopsis. DNA-da...

journal_title：DNA repair

authors： Furukawa T,Curtis MJ,Tominey CM,Duong YH,Wilcox BW,Aggoune D,Hays JB,Britt AB

更新日期：2010-09-04 00:00:00

abstract：:Mutations induced by polycyclic aromatic hydrocarbons (PAH) are expected to be produced when error-prone DNA replication occurs across unrepaired DNA lesions formed by reactive PAH metabolites such as diol epoxides. The mutagenicity of the two PAH-diol epoxides (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenz...

journal_title：DNA repair

authors： Lagerqvist A,Håkansson D,Prochazka G,Lundin C,Dreij K,Segerbäck D,Jernström B,Törnqvist M,Seidel A,Erixon K,Jenssen D

更新日期：2008-08-02 00:00:00

abstract：:Deinococcus radiodurans recovering from the effect of acute dose of gamma (gamma) radiation shows a biphasic mechanism of DNA double strands breaks repair that involves an efficient homologous recombination. However, it shows higher sensitivity to near-UV (NUV) than Escherichia coli and lacks RecBC, a DNA strand break...

journal_title：DNA repair

authors： Khairnar NP,Kamble VA,Misra HS

更新日期：2008-01-01 00:00:00

abstract：:AA8 Chinese hamster ovary cells were treated with halogenated nucleosides analogues of thymidine, namely CldU, 5-iodo-2'-deoxyuridine (IdU), and 5-bromo-2'-deoxyuridine (BrdU), following different experimental protocols. The purpose was to see whether incorporation of exogenous pyrimidine analogues into DNA could inte...

journal_title：DNA repair

authors： Cortés F,Pastor N,Mateos S,Domínguez I

更新日期：2003-06-11 00:00:00

abstract：:We have identified two fission yeast homologs of budding yeast Rad4 and human xeroderma pigmentosum complementation group C (XP-C) correcting protein, designated Rhp4A and Rhp4B. Here we show that the rhp4 genes encode NER factors that are required for UV-induced DNA damage repair in fission yeast. The rhp4A-deficient...

journal_title：DNA repair

authors： Fukumoto Y,Hiyama H,Yokoi M,Nakaseko Y,Yanagida M,Hanaoka F

更新日期：2002-10-01 00:00:00

abstract：:DNA strand breaks arise continuously in cells and can lead to chromosome rearrangements and genome instability or cell death. The commonest DNA breaks are DNA single-strand breaks, which arise at a frequency of tens-of-thousands per cell each day and which can block the progression of RNA/DNA polymerases and disrupt g...

journal_title：DNA repair

authors： Caldecott KW

更新日期：2014-07-01 00:00:00

abstract：:The extremely radiation resistant bacterium, Deinococcus radiodurans, contains a spectrum of genes that encode for multiple activities that repair DNA damage. We have cloned and expressed the product of three predicted uracil-DNA glycosylases to determine their biochemical function. DR0689 is a homologue of the Escher...

journal_title：DNA repair

authors： Sandigursky M,Sandigursky S,Sonati P,Daly MJ,Franklin WA

更新日期：2004-02-03 00:00:00

abstract：:In budding yeast, the Rad9 protein is an important player in the maintenance of genomic integrity and has a well-characterised role in DNA damage checkpoint activation. Recently, roles for different post-translational histone modifications in the DNA damage response, including H2A serine 129 phosphorylation and H3 lys...

journal_title：DNA repair

authors： Toh GW,O'Shaughnessy AM,Jimeno S,Dobbie IM,Grenon M,Maffini S,O'Rorke A,Lowndes NF

更新日期：2006-06-10 00:00:00