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A PIAS-ed view of DNA double strand break repair focuses on SUMO.

Abstract：

:Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of genomic integrity. Recently, in addition to phosphorylation, other post-translational modifications such as ubiquitylation and SUMOylation have emerged as important regulators of the DDR network. Two recent papers highlight the importance of SUMO modifications of proteins that execute the response to DNA damage.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Zlatanou A,Stewart GS

doi

10.1016/j.dnarep.2010.02.003

subject

Has Abstract

pub_date

2010-05-04 00:00:00

pages

588-92

issue

5

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(10)00038-8

journal_volume

9

pub_type

杂志文章,评审

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