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Rothmund-Thomson syndrome helicase, RECQ4: on the crossroad between DNA replication and repair.

Abstract：

:RECQ proteins are conserved DNA helicases in both prokaryotes and eukaryotes. The importance of the RECQ family helicases in human health is demonstrated by their roles as cancer suppressors that are vital for preserving genome integrity. Mutations in one of the RECQ family proteins, RECQ4, not only result in developmental abnormalities and cancer predispositions, but are also linked to premature aging. Therefore, defining the function and regulation of the RECQ4 protein is fundamental to our understanding of both the aging process and cancer pathogenesis. This review will summarize the clinical effect of RECQ4 in human health, and discuss the recent progress and debate in defining the complex molecular function of RECQ4 in DNA metabolism.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Liu Y

doi

10.1016/j.dnarep.2010.01.006

subject

Has Abstract

pub_date

2010-03-02 00:00:00

pages

325-30

issue

3

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(10)00009-1

journal_volume

9

pub_type

杂志文章,评审

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