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xni-deficient Escherichia coli are proficient for recombination and multiple pathways of repair.

Abstract：

:Single-strand-dependent DNA exonucleases play important roles in DNA repair and recombination in all organisms. In Escherichia coli the redundant functions provided by the RecJ, ExoI, ExoVII and ExoX exonucleases are required for mismatch repair, UV resistance and homologous recombination. We have examined whether the xni gene product, the single-strand exonuclease ExoIX, is also a member of this group. We find that deletion of xni has no effect on the above processes, or on resistance to oxidative damage, even in combination with other exonuclease mutations. We conclude that the xni gene product does not belong to this group of nucleases that play redundant roles in DNA recombination and repair.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Lombardo MJ,Aponyi I,Ray MP,Sandigursky M,Franklin WA,Rosenberg SM

doi

10.1016/s1568-7864(03)00135-6

keywords:

subject

Has Abstract

pub_date

2003-11-21 00:00:00

pages

1175-83

issue

11

eissn

1568-7864

issn

1568-7856

pii

S1568786403001356

journal_volume

2

pub_type

杂志文章

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