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The hidden side of unstable DNA repeats: Mutagenesis at a distance.

Abstract：

:Structure-prone DNA repeats are common components of genomic DNA in all kingdoms of life. In humans, these repeats are linked to genomic instabilities that result in various hereditary disorders, including many cancers. It has long been known that DNA repeats are not only highly polymorphic in length but can also cause chromosomal fragility and stimulate gross chromosomal rearrangements, i.e., deletions, duplications, inversions, translocations and more complex shuffles. More recently, it has become clear that inherently unstable DNA repeats dramatically elevate mutation rates in surrounding DNA segments and that these mutations can occur up to ten kilobases away from the repetitive tract, a phenomenon we call repeat-induced mutagenesis (RIM). This review describes experimental data that led to the discovery and characterization of RIM and discusses the molecular mechanisms that could account for this phenomenon.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Shah KA,Mirkin SM

doi

10.1016/j.dnarep.2015.04.020

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

106-112

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(15)00112-3

journal_volume

32

pub_type

杂志文章,评审

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