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Recruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for survival.

Abstract：

:PriA, a 3'-->5' superfamily 2 DNA helicase, acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. The ability of PriA to initiate replication at stalled forked structures ensures complete genome replication and helps to protect the cell from illegitimate recombination events. This review focuses on the activities of PriA and its role in replication fork assembly and maintaining genomic integrity.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Gabbai CB,Marians KJ

doi

10.1016/j.dnarep.2009.12.009

subject

Has Abstract

pub_date

2010-03-02 00:00:00

pages

202-9

issue

3

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(09)00337-1

journal_volume

9

pub_type

杂志文章,评审

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