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The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability.

Abstract：

:Mitochondria are membrane-bound organelles found in eukaryotic cells where they generate energy through the respiratory chain. They contain their own genome that encodes genes critical to the mitochondrial function, but most of their protein content is synthetized from nuclear encoded genes. Damages to the mtDNA can cause mutations and rearrangements with an impact on the respiratory functions of the cell. DNA repair factors are able to localize to mitochondria to restore mtDNA integrity and ensure its proper inheritance. We describe in this article the mitochondrial localization of the Mph1/FANCM helicase that serves critical roles in nuclear DNA repair processes. Mph1 localizes to mitochondria and its functions contribute to the mtDNA integrity under mtDNA damaging conditions.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Bernal M,Yang X,Lisby M,Mazón G

doi

10.1016/j.dnarep.2019.102684

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

102684

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(19)30086-2

journal_volume

82

pub_type

杂志文章

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