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Transcriptional responses to DNA damage.

Abstract：

:In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage. We review differences in observed transcriptional responses as a function of cell cycle stage and emphasize the importance of experimental design in these transcriptional response studies. We additionally consider topics including structural challenges in the transcriptional response to DNA damage as well as the connection between transcription and protein abundance.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Silva E,Ideker T

doi

10.1016/j.dnarep.2019.05.002

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

40-49

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(19)30002-3

journal_volume

79

pub_type

杂志文章,评审

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