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Paradoxical roles of cyclin D1 in DNA stability.

Abstract：

:Maintenance of DNA integrity is vital for all of the living organisms. Consequence of DNA damaging ranges from, introducing harmless synonymous mutations, to causing disease-associated mutations, genome instability, and cell death. A cell cycle protein cyclin D1 is an established cancer-driving protein. However, contribution of cyclin D1 to cancer formation and cancer survival is not entirely known. In cancer tissues, overexpression of cyclin D1 is associated with both cancer genome instability, and resistance to DNA-damaging cancer drugs. Emerging evidence indicated that cyclin D1 may play novel direct roles in regulating DNA repair. Here we provide an insight how cyclin D1 expression may contribute to DNA repair and chromosome instability, and how these functions may facilitate cancer formation, and drug resistance.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Jirawatnotai S,Sittithumcharee G

doi

10.1016/j.dnarep.2016.04.011

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

56-62

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(16)30026-X

journal_volume

42

pub_type

杂志文章,评审

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