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XRCC1 protein; Form and function.

Abstract：

:The human gene that encodes XRCC1 was cloned nearly thirty years ago but experimental analysis of this fascinating protein is still unveiling new insights into the DNA damage response. XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) including DNA kinase, DNA phosphatase, DNA polymerase, DNA deadenylase, and DNA ligase activities that collectively are capable of accelerating the repair of a broad range of DNA single-strand breaks (SSBs). Arguably the most exciting aspect of XRCC1 function that has emerged in the last few years is its intimate relationship with PARP1 activity and critical role in preventing hereditary neurodegenerative disease. Here, I provide an update on our current understanding of XRCC1, and on the impact of hereditary mutations in this protein and its protein partners on human disease.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Caldecott KW

doi

10.1016/j.dnarep.2019.102664

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

102664

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(19)30217-4

journal_volume

81

pub_type

杂志文章,评审

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