Abstract：
:Processivity clamps that hold DNA polymerases to DNA for processivity were the first proteins known to encircle the DNA duplex. At the time, polymerase processivity was thought to be the only function of ring shaped processivity clamps. But studies from many laboratories have identified numerous proteins that bind and function with sliding clamps. Among these processes are mismatch repair and nucleosome assembly. Interestingly, there exist polymerases that are highly processive and do not require clamps. Hence, DNA polymerase processivity does not intrinsically require that sliding clamps evolved for this purpose. We propose that polymerases evolved to require clamps as a way of ensuring that clamps are deposited on newly replicated DNA. These clamps are then used on the newly replicated daughter strands, for processes important to genomic integrity, such as mismatch repair and the assembly of nucleosomes to maintain epigenetic states of replicating cells during development.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Georgescu R,Langston L,O'Donnell Mdoi
10.1016/j.dnarep.2015.01.015subject
Has Abstractpub_date
2015-05-01 00:00:00pages
4-15eissn
1568-7864issn
1568-7856pii
S1568-7864(15)00027-0journal_volume
29pub_type
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