Abstract：
:Attempts to improve outcomes for patients with glioblastoma multiforme have focused largely on dose intensification and multimodal therapy and have been met with limited success. An alternative approach involves identifying and targeting the mechanisms responsible for tumour resistance. Recent data suggests that these high grade malignancies harbour a population of glioma stem cells that are both radioresistant and capable of initiating tumour regrowth. Furthermore, the radioresistant phenotype may be the consequence of constitutively upregulated and hyper-responsive cell cycle checkpoint pathways. This article considers whether these findings herald the dawn of a new era of effective, targeted therapy for this refractory tumour.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Chalmers AJdoi
10.1016/j.dnarep.2007.03.019subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1391-4issue
9eissn
1568-7864issn
1568-7856pii
S1568-7864(07)00141-3journal_volume
6pub_type
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