Abstract：
:From bacteria to humans, ancient stress responses enable organisms to contend with damage to both the genome and the proteome. These pathways have long been viewed as fundamentally separate responses. Yet recent discoveries from multiple fields have revealed surprising links between the two. Many DNA-damaging agents also target proteins, and mutagenesis induced by DNA damage produces variant proteins that are prone to misfolding, degradation, and aggregation. Likewise, recent studies have observed pervasive engagement of a p53-mediated response, and other factors linked to maintenance of genomic integrity, in response to misfolded protein stress. Perhaps most remarkably, protein aggregation and self-assembly has now been observed in multiple proteins that regulate the DNA damage response. The importance of these connections is highlighted by disease models of both cancer and neurodegeneration, in which compromised DNA repair machinery leads to profound defects in protein quality control, and vice versa.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Xie JL,Jarosz DFdoi
10.1016/j.dnarep.2018.08.004subject
Has Abstractpub_date
2018-11-01 00:00:00pages
23-32eissn
1568-7864issn
1568-7856pii
S1568-7864(18)30169-1journal_volume
71pub_type
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