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One ring to bring them all--the role of Ku in mammalian non-homologous end joining.

Abstract：

:The repair of DNA double strand breaks is essential for cell survival and several conserved pathways have evolved to ensure their rapid and efficient repair. The non-homologous end joining pathway is initiated when Ku binds to the DNA break site. Ku is an abundant nuclear heterodimer of Ku70 and Ku80 with a toroidal structure that allows the protein to slide over the broken DNA end and bind with high affinity. Once locked into placed, Ku acts as a tool-belt to recruit multiple interacting proteins, forming one or more non-homologous end joining complexes that act in a regulated manner to ensure efficient repair of DNA ends. Here we review the structure and functions of Ku and the proteins with which it interacts during non-homologous end joining.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Grundy GJ,Moulding HA,Caldecott KW,Rulten SL

doi

10.1016/j.dnarep.2014.02.019

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

30-8

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(14)00060-3

journal_volume

17

pub_type

杂志文章,评审

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