Abstract：
:DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands. Dormant origins now emerge as a key component for cells to successfully accomplish such a demanding but essential task. In this perspective, we will first provide an overview of the fundamental processes eukaryotic cells have developed to regulate origin licensing and firing. With a special focus on mammalian systems, we will then highlight the role of dormant origins in preventing replication-associated genome instability and their functional interplay with proteins involved in the DNA damage repair response for tumor suppression. Lastly, deficiencies in the origin licensing machinery will be discussed in relation to their influence on stem cell maintenance and human diseases.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Shima N,Pederson KDdoi
10.1016/j.dnarep.2017.06.019subject
Has Abstractpub_date
2017-08-01 00:00:00pages
166-173eissn
1568-7864issn
1568-7856pii
S1568-7864(17)30219-7journal_volume
56pub_type
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