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A C. elegans homolog of the Cockayne syndrome complementation group A gene.

Abstract：

:Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA and CSB. The links between the molecular functions of the CS genes and the complex pathophysiology of CS are as of yet poorly understood and are the subject of intense debate. While mouse models reflect the complexity of CS, studies on simpler genetic models might shed new light on the consequences of CS mutations. Here we describe a functional homolog of the human CSA gene in Caenorhabditis elegans. Similar to its human counterpart, mutations in the nematode csa-1 gene lead to developmental growth defects as a consequence of DNA lesions.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Babu V,Hofmann K,Schumacher B

doi

10.1016/j.dnarep.2014.09.011

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

57-62

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(14)00242-0

journal_volume

24

pub_type

杂志文章

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