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DNA repair mechanisms in dividing and non-dividing cells.

Abstract：

:DNA damage created by endogenous or exogenous genotoxic agents can exist in multiple forms, and if allowed to persist, can promote genome instability and directly lead to various human diseases, particularly cancer, neurological abnormalities, immunodeficiency and premature aging. To avoid such deleterious outcomes, cells have evolved an array of DNA repair pathways, which carry out what is typically a multiple-step process to resolve specific DNA lesions and maintain genome integrity. To fully appreciate the biological contributions of the different DNA repair systems, one must keep in mind the cellular context within which they operate. For example, the human body is composed of non-dividing and dividing cell types, including, in the brain, neurons and glial cells. We describe herein the molecular mechanisms of the different DNA repair pathways, and review their roles in non-dividing and dividing cells, with an eye toward how these pathways may regulate the development of neurological disease.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Iyama T,Wilson DM 3rd

doi

10.1016/j.dnarep.2013.04.015

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

620-36

issue

8

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(13)00096-7

journal_volume

12

pub_type

杂志文章,评审

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