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Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair.

Abstract：

:Ubiquitin conjugation plays critical roles in virtually all DNA repair pathways. This review provides an overview of the known multi-domain RING/Ubox E3 ligases and their domain structures. An analysis of known RING/Ubox X-ray and NMR structures leads to a discussion of the effects of dimerization. Structural and mechanistic data relating to the E3 ligase preferences for E2 interaction and chain-type specificity are reviewed and the role of the E3 ligases in regulation of the repair pathways is discussed.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Hibbert RG,Mattiroli F,Sixma TK

doi

10.1016/j.dnarep.2009.01.014

subject

Has Abstract

pub_date

2009-04-05 00:00:00

pages

525-35

issue

4

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(09)00018-4

journal_volume

8

pub_type

杂志文章,评审

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