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Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer.

Abstract：

:Mice defective in the mismatch repair (MMR) gene Msh2 manifest an enhanced predisposition to skin cancer associated with exposure to UVB radiation. This predisposition is further heightened if the mice are additionally defective for the nucleotide excision repair gene Xpc. To test the hypothesis that the predisposition of Msh2 mutant mice to skin cancer reflects a mutator phenotype associated with increased proliferation of skin cells following exposure to UV radiation, Msh2 mutant mice were exposed to the tumor promoter TPA. Such mice showed a robust proliferative response in the skin, but did not manifest evidence of dysplasia or neoplasia. We conclude that the predisposition of Msh2 mice to UVB radiation-induced skin cancer reflects an interaction between the processes of mismatch repair and some other excision repair mode, the exact nature of which remains to be established.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Meira LB,Cheo DL,Reis AM,Claij N,Burns DK,te Riele H,Friedberg EC

doi

10.1016/s1568-7864(02)00143-x

keywords:

subject

Has Abstract

pub_date

2002-11-03 00:00:00

pages

929-34

issue

11

eissn

1568-7864

issn

1568-7856

pii

S156878640200143X

journal_volume

1

pub_type

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