当前位置： SCI文献检索 > DNA REPAIR期刊下所有文献 > Bacillus subtilis DisA helps to circumvent replicative stress during spore revival.

Bacillus subtilis DisA helps to circumvent replicative stress during spore revival.

Abstract：

:The mechanisms that allow to circumvent replicative stress, and to resume DNA synthesis are poorly understood in Bacillus subtilis. To study the role of the diadenylate cyclase DisA and branch migration translocase (BMT) RadA/Sms in restarting a stalled replication fork, we nicked and broke the circular chromosome of an inert mature haploid spore, damaged the bases, and measured survival of reviving spores. During undisturbed ripening, nicks and breaks should be repaired by pathways that do not invoke long-range end resection or genetic exchange by homologous recombination, after which DNA replication might be initiated. We found that DNA damage reduced the viability of spores that lacked DisA, BMT (RadA/Sms, RuvAB or RecG), the Holliday junction resolvase RecU, or the translesion synthesis DNA polymerases (PolY1 or PolY2). DisA and RadA/Sms, in concert with RuvAB, RecG, RecU, PolY1 or PolY2, are needed to bypass replication-blocking lesions. DisA, which binds to stalled or reversed forks, did not apparently affect initiation of PriA-dependent DNA replication in vitro. We propose that DisA is necessary to coordinate responses to replicative stress; it could help to circumvent damaged template bases that otherwise impede fork progression.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Raguse M,Torres R,Seco EM,Gándara C,Ayora S,Moeller R,Alonso JC

doi

10.1016/j.dnarep.2017.09.006

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

57-68

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(17)30233-1

journal_volume

59

pub_type

杂志文章

相关文献

DNA REPAIR文献大全
  • Polk mutant mice have a spontaneous mutator phenotype.

    abstract：:Mice defective for the Polk gene, which encodes DNA polymerase kappa, are viable and do not manifest obvious phenotypes. The present studies document a spontaneous mutator phenotype in Polk(-/-) mice. The initial indication of enhanced spontaneous mutations in these mice came from the serendipitous observation of a po...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2009.09.003

    authors： Stancel JN,McDaniel LD,Velasco S,Richardson J,Guo C,Friedberg EC

    更新日期：2009-12-03 00:00:00

  • DNA damage in blood cells in relation to chemotherapy and nutritional status in colorectal cancer patients-A pilot study.

    abstract：:DNA damage can be considered as a biomarker for toxicity and response to chemotherapy. It is not known whether the chemotherapy-induced genotoxicity is associated with malnutrition. In this pilot study, we assess genotoxicity by means of DNA damage in patients with lymph-node positive colorectal cancer (CRC) and explo...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2018.01.005

    authors： Kværner AS,Minaguchi J,Yamani NE,Henriksen C,Ræder H,Paur I,Henriksen HB,Wiedswang G,Smeland S,Blomhoff R,Collins AR,Bøhn SK

    更新日期：2018-03-01 00:00:00

  • Both R-loop removal and ribonucleotide excision repair activities of RNase H2 contribute substantially to chromosome stability.

    abstract：:Cells carrying deletions of genes encoding H-class ribonucleases display elevated rates of chromosome instability. The role of these enzymes is to remove RNA-DNA associations including persistent mRNA-DNA hybrids (R-loops) formed during transcription, and ribonucleotides incorporated into DNA during replication. RNase...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2017.02.012

    authors： Cornelio DA,Sedam HN,Ferrarezi JA,Sampaio NM,Argueso JL

    更新日期：2017-04-01 00:00:00

  • Reversibility of replicative senescence in Saccharomyces cerevisiae: effect of homologous recombination and cell cycle checkpoints.

    abstract：:Primary human somatic cells grown in culture divide a finite number of times, exhibiting progressive changes in metabolism and morphology before cessation of cycling. This telomere-initiated cellular senescence occurs because cells have halted production of telomerase, a DNA polymerase required for stabilization of ch...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2011.10.003

    authors： Becerra SC,Thambugala HT,Erickson AR,Lee CK,Lewis LK

    更新日期：2012-01-02 00:00:00

  • The hyper unequal sister chromatid recombination in an sgs1 mutant of budding yeast requires MSH2.

    abstract：:Budding yeast SGS1 and the human Bloom's syndrome (BS) gene, BLM, are homologues of the Escherichia coli recQ. Cells derived from BS patients are characterized by a dramatic increase in sister chromatid exchange (SCE). We previously reported that budding yeast cells deficient in SGS1 showed an increase in the frequenc...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2004.05.008

    authors： Onoda F,Seki M,Wang W,Enomoto T

    更新日期：2004-10-05 00:00:00

  • The overexpression of specialized DNA polymerases in cancer.

    abstract：:Specialized DNA polymerases are required to bypass DNA damage lesions that would otherwise cause replication arrest and cell death. When operating on non-canonical templates, such as undamaged DNA or on non-cognate lesions, these polymerases exhibit considerably reduced fidelity, resulting in the generation of mutatio...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2005.01.005

    authors： Albertella MR,Lau A,O'Connor MJ

    更新日期：2005-05-02 00:00:00

  • Loss of RecQ5 leads to spontaneous mitotic defects and chromosomal aberrations in Drosophila melanogaster.

    abstract：:RecQ5 belongs to the RecQ DNA helicase family that includes genes causative of Bloom, Werner, and Rothmund-Thomson syndromes. Although no human disease has been genetically linked to a mutation in RecQ5, Drosophila melanogaster RecQ5 is highly expressed in early embryos, suggesting an important role for it in the DNA ...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2008.10.007

    authors： Nakayama M,Yamaguchi S,Sagisu Y,Sakurai H,Ito F,Kawasaki K

    更新日期：2009-02-01 00:00:00

  • Mutations, protein homeostasis, and epigenetic control of genome integrity.

    abstract：:From bacteria to humans, ancient stress responses enable organisms to contend with damage to both the genome and the proteome. These pathways have long been viewed as fundamentally separate responses. Yet recent discoveries from multiple fields have revealed surprising links between the two. Many DNA-damaging agents a...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2018.08.004

    authors： Xie JL,Jarosz DF

    更新日期：2018-11-01 00:00:00

  • Sensitivity of human cells expressing low-fidelity or weak-catalytic-activity variants of DNA polymerase ζ to genotoxic stresses.

    abstract：:Translesion DNA polymerases (TLS pols) play critical roles in defense mechanisms against genotoxic agents. The defects or mutations of TLS pols are predicted to result in hypersensitivity of cells to environmental mutagens. In this study, human cells expressing DNA polymerase ζ (Pol ζ) variants with low fidelity or we...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2016.06.002

    authors： Suzuki T,Grúz P,Honma M,Adachi N,Nohmi T

    更新日期：2016-09-01 00:00:00

  • Novel role of tyrosine in catalysis by human AP endonuclease 1.

    abstract：:Apurinic/apyrimidinic endonuclease (AP endo, HAP1) recognizes abasic sites in ds DNA and makes a single nick in the backbone 5' to the abasic site. In this report we examine the roles of three conserved tyrosine residues in close proximity to the active site. We show that Tyr(128) and Tyr(269), which interact upstream...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2004.06.009

    authors： Mundle ST,Fattal MH,Melo LF,Coriolan JD,O'Regan NE,Strauss PR

    更新日期：2004-11-02 00:00:00

  • RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae.

    abstract：:Exposure to ionizing radiation results in a variety of genome rearrangements that have been linked to tumor formation. Many of these rearrangements are thought to arise from the repair of double-strand breaks (DSBs) by several mechanisms, including homologous recombination (HR) between repetitive sequences dispersed t...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2008.02.003

    authors： Pannunzio NR,Manthey GM,Bailis AM

    更新日期：2008-05-03 00:00:00

  • Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae.

    abstract：:Pyridine nucleotides are essential coenzymes in many cellular redox reactions in all living systems. In addition to functioning as a redox carrier, NAD(+) is also a required co-substrate for the conserved sirtuin deacetylases. Sirtuins regulate transcription, genome maintenance and metabolism and function as molecular...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2014.07.009

    authors： Kato M,Lin SJ

    更新日期：2014-11-01 00:00:00

  • The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells.

    abstract：:It is vital that embryonic stem (ES) cells, which give rise to the diverse tissues of the mature organism, maintain genetic stability. To understand mechanisms for the prevention and causation of chromosomal instability, we have used spectral karyotyping (SKY) to analyse ES cells from wild-type and repair-gene knockou...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2005.05.005

    authors： Griffin C,Waard Hd,Deans B,Thacker J

    更新日期：2005-08-15 00:00:00

  • Human OGG1 activity in nucleosomes is facilitated by transient unwrapping of DNA and is influenced by the local histone environment.

    abstract：:If unrepaired, damage to genomic DNA can cause mutations and/or be cytotoxic. Single base lesions are repaired via the base excision repair (BER) pathway. The first step in BER is the recognition and removal of the nucleobase lesion by a glycosylase enzyme. For example, human oxoguanine glycosylase 1 (hOGG1) is respon...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2017.08.010

    authors： Bilotti K,Kennedy EE,Li C,Delaney S

    更新日期：2017-11-01 00:00:00

  • The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks.

    abstract：:Mammalian cells possess multiple closely related SWI/SNF chromatin remodelling complexes. These complexes have been implicated in the cellular response to DNA double strand breaks (DSBs). Evidence suggests that SWI/SNF complexes contribute to successful repair via both the homologous recombination and non-homologous e...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2020.102919

    authors： Harrod A,Lane KA,Downs JA

    更新日期：2020-09-01 00:00:00

  • Tousled homolog, TLK1, binds and phosphorylates Rad9; TLK1 acts as a molecular chaperone in DNA repair.

    abstract：:The Tousled-like kinases are involved in chromatin assembly, DNA repair, transcription, and chromosome segregation. In this work, we show that overexpression of TLK1B hastens repair of double strand breaks (DSBs) in mouse cells. We have identified Rad9 as a protein interacting tightly with TLK1B. TLK1B phosphorylates ...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2008.09.005

    authors： Sunavala-Dossabhoy G,De Benedetti A

    更新日期：2009-01-01 00:00:00

  • Nucleolytic processing of a protein-bound DNA end by the E. coli SbcCD (MR) complex.

    abstract：:SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and have been postulated to play roles in removing protein bound to DNA termini. Here we provide direct evidence that the Escherichia coli MR complex (SbcCD) removes protein from a pro...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/s1568-7864(03)00063-6

    authors： Connelly JC,de Leau ES,Leach DR

    更新日期：2003-07-16 00:00:00

  • Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths.

    abstract：:DNA double-strand breaks (DSBs) in yeast are repaired by homologous recombination (HR) and non-homologous end-joining (NHEJ). Rad51 forms nucleoprotein filaments at processed broken ends that effect strand exchange, forming heteroduplex DNA (hDNA) that gives rise to a gene conversion tract. We hypothesized that excess...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2005.03.003

    authors： Paffett KS,Clikeman JA,Palmer S,Nickoloff JA

    更新日期：2005-06-08 00:00:00

  • Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures.

    abstract：:A large number of lymphoid malignancies is characterized by specific chromosomal translocations, which are closely linked to the initial steps of pathogenesis. The hallmark of these translocations is the ectopic activation of a silent proto-oncogene through its relocation at the vicinity of an active regulatory elemen...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2006.05.015

    authors： Marculescu R,Vanura K,Montpellier B,Roulland S,Le T,Navarro JM,Jäger U,McBlane F,Nadel B

    更新日期：2006-09-08 00:00:00

  • A PIAS-ed view of DNA double strand break repair focuses on SUMO.

    abstract：:Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of genomic integrity. Recently, in addition to phosphorylation, other post-translational modifications such as ubiquitylation and SUMOylation have emerged as impor...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2010.02.003

    authors： Zlatanou A,Stewart GS

    更新日期：2010-05-04 00:00:00

  • Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair.

    abstract：:Accumulation of 8-oxo-7,8-dihydroguanine (8-oxoG) in the DNA results in genetic instability and mutagenesis, and is believed to contribute to carcinogenesis, aging processes and various aging-related diseases. 8-OxoG is removed from the DNA via DNA base excision repair (BER), initiated by 8-oxoguanine DNA glycosylase-...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2013.06.006

    authors： German P,Szaniszlo P,Hajas G,Radak Z,Bacsi A,Hazra TK,Hegde ML,Ba X,Boldogh I

    更新日期：2013-10-01 00:00:00

  • Transcriptional responses to DNA damage.

    abstract：:In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage. We review difference...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2019.05.002

    authors： Silva E,Ideker T

    更新日期：2019-07-01 00:00:00

  • recX, a new SOS gene that is co-transcribed with the recA gene in Escherichia coli.

    abstract：:recX is a small open reading frame located downstream of recA that is conserved in many bacteria. In Escherichia coli, the recX gene (also named oraA) is a 501 bp open reading frame that encodes a predicted basic protein. Transcriptional analysis by Northern blots showed that in E. coli the recX gene is SOS-regulated....

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/s1568-7864(02)00217-3

    authors： Pagès V,Koffel-Schwartz N,Fuchs RP

    更新日期：2003-03-01 00:00:00

  • CtIP: A DNA damage response protein at the intersection of DNA metabolism.

    abstract：:The mammalian CtIP protein and its orthologs in other eukaryotes promote the resection of DNA double-strand breaks and are essential for meiotic recombination. Here we review the current literature supporting the role of CtIP in DNA end processing and the importance of CtIP endonuclease activity in DNA repair. We also...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2015.04.016

    authors： Makharashvili N,Paull TT

    更新日期：2015-08-01 00:00:00

  • Influence of XPB helicase on recruitment and redistribution of nucleotide excision repair proteins at sites of UV-induced DNA damage.

    abstract：:The XPB DNA helicase, a subunit of the basal transcription factor TFIIH, is also involved in nucleotide excision repair (NER). We examined recruitment of NER proteins in XP-B cells from patients with mild or severe xeroderma pigmentosum (XP) having different XPB mutations using local UV-irradiation through filters wit...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2007.03.025

    authors： Oh KS,Imoto K,Boyle J,Khan SG,Kraemer KH

    更新日期：2007-09-01 00:00:00

  • Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions.

    abstract：:Srs2 is a 3'-5' DNA helicase that regulates many aspects of DNA metabolism in Saccharomyces cerevisiae. It is best known for its ability to counteract homologous recombination by dismantling Rad51 filaments, but is also involved in checkpoint activation, adaptation and recovery, and in resolution of late recombination...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2011.02.004

    authors： León Ortiz AM,Reid RJ,Dittmar JC,Rothstein R,Nicolas A

    更新日期：2011-05-05 00:00:00

  • Measurement of DNA damage in peripheral blood by the γ-H2AX assay as predictor of colorectal cancer risk.

    abstract：:The detection of γ-H2AX focus is one of the most sensitive ways to monitor DNA double-strand breaks (DSBs). Although changes in γ-H2AX activity have been studied in tumor cells in colorectal cancer (CRC), changes in peripheral blood lymphocytes (PBLs) have not been examined previously. We hypothesize that higher level...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2017.03.001

    authors： Zhao L,Chang DW,Gong Y,Eng C,Wu X

    更新日期：2017-05-01 00:00:00

  • Mysterious and fascinating: DNA polymerase ɩ remains enigmatic 20 years after its discovery.

    abstract：:With the publication of the first paper describing the biochemical properties of DNA polymerase iota (polɩ), the question immediately arose as to why cells harbor such a low-fidelity enzyme which often violates the Watson-Crick base pairing rules? Yet 20 years after its discovery, the cellular function of polɩ remains...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2020.102914

    authors： Vaisman A,Woodgate R

    更新日期：2020-09-01 00:00:00

  • The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation.

    abstract：:ATM and ATR are stress-response kinases which respond to a variety of insults including ionizing radiation, replication arrest, ultraviolet radiation and hypoxia/re-oxygenation. Hypoxia occupies a unique niche in the study of both ATR- and ATM-mediated checkpoint pathways. Hypoxia is a physiologically significant stre...

    journal_title：DNA repair

    pub_type： 杂志文章,评审

    doi：10.1016/j.dnarep.2004.03.035

    authors： Hammond EM,Giaccia AJ

    更新日期：2004-08-01 00:00:00

  • DNA decay and limited Rad53 activation after liquid holding of UV-treated nucleotide excision repair deficient S. cerevisiae cells.

    abstract：:The DNA damage checkpoint is a surveillance mechanism activated by DNA lesions and devoted to the maintenance of genome stability. It is considered as a signal transduction cascade, involving a sensing step, the activation of a set of protein kinases and the transmission and amplification of the damage signal through ...

    journal_title：DNA repair

    pub_type： 杂志文章

    doi：10.1016/j.dnarep.2004.06.019

    authors： Giannattasio M,Lazzaro F,Siede W,Nunes E,Plevani P,Muzi-Falconi M

    更新日期：2004-12-02 00:00:00