Abstract：
:SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and have been postulated to play roles in removing protein bound to DNA termini. Here we provide direct evidence that the Escherichia coli MR complex (SbcCD) removes protein from a protein-bound DNA end by inserting a double-strand break (DSB). These observations indicate a more complex biochemical action than has been assumed previously and argue that this class of protein has the potential to play a direct role in deprotecting protein-bound DNA ends in vivo.
journal_name
DNA Repair (Amst)journal_title
DNA repairauthors
Connelly JC,de Leau ES,Leach DRdoi
10.1016/s1568-7864(03)00063-6keywords:
subject
Has Abstractpub_date
2003-07-16 00:00:00pages
795-807issue
7eissn
1568-7864issn
1568-7856pii
S1568786403000636journal_volume
2pub_type
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