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DNA double-strand breaks as drivers of neural genomic change, function, and disease.

Abstract：

:Early work from about two decades ago implicated DNA double-strand break (DSB) formation and repair in neuronal development. Findings emerging from recent studies of DSBs in proliferating neural progenitors and in mature, non-dividing neurons suggest important roles of DSBs in brain physiology, aging, cancer, psychiatric and neurodegenerative disorders. We provide an overview of some findings and speculate on what may lie ahead.

journal_name

DNA Repair (Amst)

journal_title

DNA repair

authors

Alt FW,Schwer B

doi

10.1016/j.dnarep.2018.08.019

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

158-163

eissn

1568-7864

issn

1568-7856

pii

S1568-7864(18)30184-8

journal_volume

71

pub_type

杂志文章,评审

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