Spt6 is a maintenance factor for centromeric CENP-A.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Zheng J,Fan R,Wu H,Yao H,Yan Y,Liu J,Ran L,Sun Z,Yi L,Dang L,Gan P,Zheng P,Yang T,Zhang Y,Tang T,Wang Y

更新日期：2020-07-27 00:00:00

abstract：:The breast cancer susceptibility gene BRCA1 is well known for its function in double-strand break (DSB) DNA repair. While BRCA1 is also implicated in transcriptional regulation, the physiological significance remains unclear. COBRA1 (also known as NELF-B) is a BRCA1-binding protein that regulates RNA polymerase II (RN...

journal_title：Nature communications

authors： Nair SJ,Zhang X,Chiang HC,Jahid MJ,Wang Y,Garza P,April C,Salathia N,Banerjee T,Alenazi FS,Ruan J,Fan JB,Parvin JD,Jin VX,Hu Y,Li R

更新日期：2016-03-04 00:00:00

abstract：:Genetic heterogeneity between and within tumours is a major factor determining cancer progression and therapy response. Here we examined DNA sequence and DNA copy-number heterogeneity in colorectal cancer (CRC) by targeted high-depth sequencing of 100 most frequently altered genes. In 97 samples, with primary tumours ...

journal_title：Nature communications

authors： Mamlouk S,Childs LH,Aust D,Heim D,Melching F,Oliveira C,Wolf T,Durek P,Schumacher D,Bläker H,von Winterfeld M,Gastl B,Möhr K,Menne A,Zeugner S,Redmer T,Lenze D,Tierling S,Möbs M,Weichert W,Folprecht G,Blanc E,

更新日期：2017-01-25 00:00:00

abstract：:The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein depletion technology Trim-Away. This activity is dependent on formation of self-anchored, K63-linked ubiquitin chains by the heterodimeric E2 enzyme Ube2N/Ube2V2....

journal_title：Nature communications

authors： Kiss L,Zeng J,Dickson CF,Mallery DL,Yang JC,McLaughlin SH,Boland A,Neuhaus D,James LC

更新日期：2019-10-03 00:00:00

abstract：:The central issues for understanding iron (Fe)-based superconductors are the symmetry and structure of the superconducting gap. So far the experimental data and theoretical models have been highly controversial. Some experiments favor two or more constant or nearly constant gaps, others indicate strong anisotropy and ...

journal_title：Nature communications

authors： Zeng B,Mu G,Luo HQ,Xiang T,Mazin II,Yang H,Shan L,Ren C,Dai PC,Wen HH

更新日期：2010-11-16 00:00:00

abstract：:Loss of protein and organelle quality control secondary to reduced autophagy is a hallmark of aging. However, the physiologic and molecular regulation of autophagy in long-lived organisms remains incompletely understood. Here we show that the Kruppel-like family of transcription factors are important regulators of aut...

journal_title：Nature communications

authors： Hsieh PN,Zhou G,Yuan Y,Zhang R,Prosdocimo DA,Sangwung P,Borton AH,Boriushkin E,Hamik A,Fujioka H,Fealy CE,Kirwan JP,Peters M,Lu Y,Liao X,Ramírez-Bergeron D,Feng Z,Jain MK

更新日期：2017-10-13 00:00:00

abstract：:It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction...

journal_title：Nature communications

authors： Robinson JE,Paluch J,Dickman DK,Joiner WJ

更新日期：2016-01-27 00:00:00

abstract：:Rosemary extracts containing the phenolic diterpenes carnosic acid and its derivative carnosol are approved food additives used in an increasingly wide range of products to enhance shelf-life, thanks to their high anti-oxidant activity. We describe here the elucidation of the complete biosynthetic pathway of carnosic ...

journal_title：Nature communications

authors： Scheler U,Brandt W,Porzel A,Rothe K,Manzano D,Božić D,Papaefthimiou D,Balcke GU,Henning A,Lohse S,Marillonnet S,Kanellis AK,Ferrer A,Tissier A

更新日期：2016-10-05 00:00:00

abstract：:Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequencing of 168 GCs. Our data demonstrates diverse models of complex SVs operative in GC, which lead to high-level a...

journal_title：Nature communications

authors： Xing R,Zhou Y,Yu J,Yu Y,Nie Y,Luo W,Yang C,Xiong T,Wu WKK,Li Z,Bing Y,Lin S,Zhang Y,Hu Y,Li L,Han L,Yang C,Huang S,Huang S,Zhou R,Li J,Wu K,Fan D,Tang G,Dou J,Zhu Z,Ji J,Fang X,Lu Y

更新日期：2019-05-02 00:00:00

abstract：:The integration of nanophotonics and atomic physics has been a long-sought goal that would open new frontiers for optical physics, including novel quantum transport and many-body phenomena with photon-mediated atomic interactions. Reaching this goal requires surmounting diverse challenges in nanofabrication and atomic...

journal_title：Nature communications

authors： Goban A,Hung CL,Yu SP,Hood JD,Muniz JA,Lee JH,Martin MJ,McClung AC,Choi KS,Chang DE,Painter O,Kimble HJ

更新日期：2014-05-08 00:00:00

abstract：:Changing climate will impact species' ranges only when environmental variability directly impacts the demography of local populations. However, measurement of demographic responses to climate change has largely been limited to single species and locations. Here we show that amphibian communities are responsive to clim...

journal_title：Nature communications

authors： Miller DAW,Grant EHC,Muths E,Amburgey SM,Adams MJ,Joseph MB,Waddle JH,Johnson PTJ,Ryan ME,Schmidt BR,Calhoun DL,Davis CL,Fisher RN,Green DM,Hossack BR,Rittenhouse TAG,Walls SC,Bailey LL,Cruickshank SS,Fellers GM,G

更新日期：2018-09-25 00:00:00

abstract：:The observations of solar flare onsets show rapid increase of hard and soft X-rays, ultra-violet emission with large Doppler blue shifts associated with plasma upflows, and Hα hydrogen emission with red shifts up to 1-4 Å. Modern radiative hydrodynamic models account well for blue-shifted emission, but struggle to rep...

journal_title：Nature communications

authors： Druett M,Scullion E,Zharkova V,Matthews S,Zharkov S,Rouppe Van der Voort L

更新日期：2017-06-27 00:00:00

abstract：:Auditory cortex neurons nonlinearly integrate synaptic inputs from the thalamus and cortex, and generate spiking outputs for simple and complex sounds. Directly comparing synaptic and spiking activity can determine whether this input-output transformation is stimulus-dependent. We employ in vivo whole-cell recordings ...

journal_title：Nature communications

authors： Kim KX,Atencio CA,Schreiner CE

更新日期：2020-02-27 00:00:00

abstract：:Ti-alloys represent the principal structural materials in both aerospace development and metallic biomaterials. Key to optimizing their mechanical and functional behaviour is in-depth know-how of their phases and the complex interplay of diffusive vs. displacive phase transformations to permit the tailoring of intrica...

journal_title：Nature communications

authors： Bönisch M,Panigrahi A,Stoica M,Calin M,Ahrens E,Zehetbauer M,Skrotzki W,Eckert J

更新日期：2017-11-10 00:00:00

abstract：:Granule cells are the dominant cell type of the olfactory bulb inhibiting mitral and tufted cells via dendrodendritic synapses; yet the factors regulating the strength of their inhibitory output, and, therefore, their impact on odour discrimination, remain unknown. Here we show that GABAAR β3-subunits are distributed ...

journal_title：Nature communications

authors： Nunes D,Kuner T

更新日期：2015-11-23 00:00:00

abstract：:Natural killer (NK) cells are cytotoxic innate lymphoid cells that are involved in immune defense. NK cell reactivity is controlled in part by MHC class I recognition by inhibitory receptors, but the underlying molecular mechanisms remain undefined. Using a mouse model of conditional deletion in NK cells, we show here...

journal_title：Nature communications

authors： Viant C,Fenis A,Chicanne G,Payrastre B,Ugolini S,Vivier E

更新日期：2014-10-30 00:00:00

abstract：:The ubiquitous SAR11 and Prochlorococcus bacteria manage to maintain a sufficient supply of phosphate in phosphate-poor surface waters of the North Atlantic subtropical gyre. Furthermore, it seems that their phosphate uptake may counter-intuitively be lower in more productive tropical waters, as if their cellular dema...

journal_title：Nature communications

authors： Zubkov MV,Martin AP,Hartmann M,Grob C,Scanlan DJ

更新日期：2015-07-22 00:00:00

abstract：: ...

journal_title：Nature communications

authors： Tsai D,Sawyer D,Bradd A,Yuste R,Shepard KL

更新日期：2018-10-24 00:00:00

abstract：:The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on single-molecule struc...

journal_title：Nature communications

authors： Conte M,Fiorillo L,Bianco S,Chiariello AM,Esposito A,Nicodemi M

更新日期：2020-07-03 00:00:00

abstract：:Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient-derived induced pl...

journal_title：Nature communications

authors： Panagiotakopoulou V,Ivanyuk D,De Cicco S,Haq W,Arsić A,Yu C,Messelodi D,Oldrati M,Schöndorf DC,Perez MJ,Cassatella RP,Jakobi M,Schneiderhan-Marra N,Gasser T,Nikić-Spiegel I,Deleidi M

更新日期：2020-10-14 00:00:00

abstract：:One prominent hallmark of topological semimetals is the existence of unusual topological surface states known as Fermi arcs. Nevertheless, the Fermi-arc superconductivity remains elusive. Here, we report the critical current oscillations from surface Fermi arcs in Nb-Dirac semimetal Cd3As2-Nb Josephson junctions. The ...

journal_title：Nature communications

authors： Li CZ,Wang AQ,Li C,Zheng WZ,Brinkman A,Yu DP,Liao ZM

更新日期：2020-03-02 00:00:00

abstract：:Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project d...

journal_title：Nature communications

authors： Kinnersley B,Labussière M,Holroyd A,Di Stefano AL,Broderick P,Vijayakrishnan J,Mokhtari K,Delattre JY,Gousias K,Schramm J,Schoemaker MJ,Fleming SJ,Herms S,Heilmann S,Schreiber S,Wichmann HE,Nöthen MM,Swerdlow A,Lathro

更新日期：2015-10-01 00:00:00

abstract：:The damming of rivers represents one of the most far-reaching human modifications of the flows of water and associated matter from land to sea. Dam reservoirs are hotspots of sediment accumulation, primary productivity (P) and carbon mineralization (R) along the river continuum. Here we show that for the period 1970-2...

journal_title：Nature communications

authors： Maavara T,Lauerwald R,Regnier P,Van Cappellen P

更新日期：2017-05-17 00:00:00

abstract：:The growth of atomically dispersed metal catalysts (ADMCs) remains a great challenge owing to the thermodynamically driven atom aggregation. Here we report a surface-limited electrodeposition technique that uses site-specific substrates for the rapid and room-temperature synthesis of ADMCs. We obtained ADMCs by the un...

journal_title：Nature communications

authors： Shi Y,Huang WM,Li J,Zhou Y,Li ZQ,Yin YC,Xia XH

更新日期：2020-09-11 00:00:00

abstract：:Predicting ecological effects of contaminants remains challenging because of the sheer number of chemicals and their ambiguous role in biodiversity-ecosystem function relationships. We evaluate responses of experimental pond ecosystems to standardized concentrations of 12 pesticides, nested in four pesticide classes a...

journal_title：Nature communications

authors： Rumschlag SL,Mahon MB,Hoverman JT,Raffel TR,Carrick HJ,Hudson PJ,Rohr JR

更新日期：2020-12-10 00:00:00

abstract：:A skullcap found in the Salkhit Valley in northeast Mongolia is, to our knowledge, the only Pleistocene hominin fossil found in the country. It was initially described as an individual with possible archaic affinities, but its ancestry has been debated since the discovery. Here, we determine the age of the Salkhit sku...

journal_title：Nature communications

authors： Devièse T,Massilani D,Yi S,Comeskey D,Nagel S,Nickel B,Ribechini E,Lee J,Tseveendorj D,Gunchinsuren B,Meyer M,Pääbo S,Higham T

更新日期：2019-01-30 00:00:00

abstract：:Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...

journal_title：Nature communications

authors： Besenbacher S,Liu S,Izarzugaza JM,Grove J,Belling K,Bork-Jensen J,Huang S,Als TD,Li S,Yadav R,Rubio-García A,Lescai F,Demontis D,Rao J,Ye W,Mailund T,Friborg RM,Pedersen CN,Xu R,Sun J,Liu H,Wang O,Cheng X,Fl

更新日期：2015-01-19 00:00:00

abstract：:With favourable error thresholds and requiring only nearest-neighbour interactions on a lattice, the surface code is an error-correcting code that has garnered considerable attention. At the heart of this code is the ability to perform a low-weight parity measurement of local code qubits. Here we demonstrate high-fide...

journal_title：Nature communications

authors： Chow JM,Gambetta JM,Magesan E,Abraham DW,Cross AW,Johnson BR,Masluk NA,Ryan CA,Smolin JA,Srinivasan SJ,Steffen M

更新日期：2014-06-24 00:00:00

abstract：:Magmatic intrusions and volcanic eruptions are intimately related phenomena. Shallow magma intrusion builds subsurface reservoirs that are drained by volcanic eruptions. Thus, the long-held view is that intrusions must precede and feed eruptions. Here we show that explosive eruptions can also cause magma intrusion. We...

journal_title：Nature communications

authors： Castro JM,Cordonnier B,Schipper CI,Tuffen H,Baumann TS,Feisel Y

更新日期：2016-11-23 00:00:00

abstract：:Apicomplexans are obligate intracellular parasites that scavenge essential nutrients from their hosts via transporter proteins on their plasma membrane. The identities of the transporters that mediate amino acid uptake into apicomplexans are unknown. Here we demonstrate that members of an apicomplexan-specific protein...

journal_title：Nature communications

authors： Rajendran E,Hapuarachchi SV,Miller CM,Fairweather SJ,Cai Y,Smith NC,Cockburn IA,Bröer S,Kirk K,van Dooren GG

更新日期：2017-02-16 00:00:00