Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development.

abstract：:Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple sclerosis. To improve our understanding of human oligodendrocyte development, which could facilitate development of remyelination-based treatment strategies, here we describe time-course single-cell-transcriptomic analysis of develop...

journal_title：Nature communications

authors： Chamling X,Kallman A,Fang W,Berlinicke CA,Mertz JL,Devkota P,Pantoja IEM,Smith MD,Ji Z,Chang C,Kaushik A,Chen L,Whartenby KA,Calabresi PA,Mao HQ,Ji H,Wang TH,Zack DJ

更新日期：2021-01-28 00:00:00

abstract：:The photons in circularly polarized light can transfer their quantized spin angular momentum to micro- and nanostructures via absorption and scattering. This normally exerts positive torque on the objects wher the sign (i.e., handedness or angular direction) follows that of the spin angular momentum. Here we show that...

journal_title：Nature communications

authors： Han F,Parker JA,Yifat Y,Peterson C,Gray SK,Scherer NF,Yan Z

更新日期：2018-11-20 00:00:00

abstract：:Replicating biological patterns is promising for designing materials with multifaceted properties. Twisted cholesteric liquid crystal patterns are found in the iridescent tessellated cuticles of many insects and a few fruits. Their accurate replication is extremely difficult since discontinuous patterns and colors mus...

journal_title：Nature communications

authors： Scarangella A,Soldan V,Mitov M

更新日期：2020-08-14 00:00:00

abstract：:Generation of periodic patterns is fundamental to the differentiation of multiple tissues during development. How such patterns form robustly is still unclear. The Drosophila eye comprises ∼750 units, whose crystalline order is set during differentiation of the eye imaginal disc: an activation wave sweeping across the...

journal_title：Nature communications

authors： Gavish A,Shwartz A,Weizman A,Schejter E,Shilo BZ,Barkai N

更新日期：2016-02-15 00:00:00

abstract：:The coupling of compartmentalisation with molecular replication is thought to be crucial for the emergence of the first evolvable chemical systems. Minimal artificial replicators have been designed based on molecular recognition, inspired by the template copying of DNA, but none yet have been coupled to compartmentali...

journal_title：Nature communications

authors： Taylor JW,Eghtesadi SA,Points LJ,Liu T,Cronin L

更新日期：2017-08-10 00:00:00

abstract：:Chemical modifications on DNA molecules, such as 5-methylcytosine and 5-hydroxymethylcytosine, play important roles in the mammalian brain. A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently been found in mammalian cells. However, the presence and function(s) of 6mA in the mammalian brain remain ...

journal_title：Nature communications

authors： Yao B,Cheng Y,Wang Z,Li Y,Chen L,Huang L,Zhang W,Chen D,Wu H,Tang B,Jin P

更新日期：2017-10-24 00:00:00

abstract：:Owing to the significant difference in the numbers of simulated and experimentally feasible zeolite structures, several alternative strategies have been developed for zeolite synthesis. Despite their rationality and originality, most of these techniques are based on trial-and-error, which makes it difficult to predict...

journal_title：Nature communications

authors： Kasneryk V,Shamzhy M,Zhou J,Yue Q,Mazur M,Mayoral A,Luo Z,Morris RE,Čejka J,Opanasenko M

更新日期：2019-11-12 00:00:00

abstract：:Understanding the details of domain wall (DW) motion along magnetic racetracks has drawn considerable interest in the past few years for their applications in non-volatile memory devices. The propagation of the DW is dictated by the interplay between its driving force, either field or current, and the complex energy l...

journal_title：Nature communications

authors： Jiang X,Thomas L,Moriya R,Hayashi M,Bergman B,Rettner C,Parkin SS

更新日期：2010-06-15 00:00:00

abstract：:KRAS mutations are present in over 90% of pancreatic ductal adenocarcinomas (PDAC), and drive their poor outcomes and failure to respond to targeted therapies. Here we show that Leukemia Inhibitory Factor (LIF) expression is induced specifically by oncogenic KRAS in PDAC and that LIF depletion by genetic means or by n...

journal_title：Nature communications

authors： Wang MT,Fer N,Galeas J,Collisson EA,Kim SE,Sharib J,McCormick F

更新日期：2019-07-11 00:00:00

abstract：:Ca2+ coordinates diverse cellular processes, yet how function-specific signals arise is enigmatic. We describe a cell-wide network of distinct cytoplasmic nanocourses with the nucleus at its centre, demarcated by sarcoplasmic reticulum (SR) junctions (≤400 nm across) that restrict Ca2+ diffusion and by nanocourse-spec...

journal_title：Nature communications

authors： Duan J,Navarro-Dorado J,Clark JH,Kinnear NP,Meinke P,Schirmer EC,Evans AM

更新日期：2019-05-24 00:00:00

abstract：:According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSN...

journal_title：Nature communications

authors： Gerstung M,Beisel C,Rechsteiner M,Wild P,Schraml P,Moch H,Beerenwinkel N

更新日期：2012-05-01 00:00:00

abstract：:Large-area light-emitting diodes (LEDs) fabricated by mass-production techniques are needed for low-cost flat-panel lighting. Nevertheless, it is still challenging to fabricate efficient large-area LEDs using organic small molecules (OLEDs), quantum dots (QLEDs), polymers (PLEDs), and recently-developed hybrid perovsk...

journal_title：Nature communications

authors： Chu S,Chen W,Fang Z,Xiao X,Liu Y,Chen J,Huang J,Xiao Z

更新日期：2021-01-08 00:00:00

abstract：:Understanding lithospheric plate motions is of paramount importance to geodynamicists. Much effort is going into kinematic reconstructions featuring progressively finer temporal resolution. However, the challenge of precisely identifying ocean-floor magnetic lineations, and uncertainties in geomagnetic reversal timesc...

journal_title：Nature communications

authors： Iaffaldano G,Bodin T,Sambridge M

更新日期：2012-01-01 00:00:00

abstract：:A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the lack of structural information regarding CDH. CDH contains a haem-bi...

journal_title：Nature communications

authors： Tan TC,Kracher D,Gandini R,Sygmund C,Kittl R,Haltrich D,Hällberg BM,Ludwig R,Divne C

更新日期：2015-07-07 00:00:00

abstract：:Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-sign...

journal_title：Nature communications

authors： Benyamin B,Esko T,Ried JS,Radhakrishnan A,Vermeulen SH,Traglia M,Gögele M,Anderson D,Broer L,Podmore C,Luan J,Kutalik Z,Sanna S,van der Meer P,Tanaka T,Wang F,Westra HJ,Franke L,Mihailov E,Milani L,Hälldin J,Win

更新日期：2014-10-29 00:00:00

abstract：:Microbial biofilm formation on indwelling medical devices causes persistent infections that cannot be cured with conventional antibiotics. To address this unmet challenge, we engineer tunable active surface topographies with micron-sized pillars that can beat at a programmable frequency and force level in an electroma...

journal_title：Nature communications

authors： Gu H,Lee SW,Carnicelli J,Zhang T,Ren D

更新日期：2020-05-05 00:00:00

abstract：:The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is the needle complex, a continuous channel formed by the highly oligomerized inner and outer membrane hollow rin...

journal_title：Nature communications

authors： Hu J,Worrall LJ,Hong C,Vuckovic M,Atkinson CE,Caveney N,Yu Z,Strynadka NCJ

更新日期：2018-09-21 00:00:00

abstract：:Negative gas adsorption (NGA) in ordered mesoporous solids is associated with giant contractive structural transitions traversing through metastable states. Here, by systematically downsizing the crystal dimensions of a mesoporous MOF (DUT-49) from several micrometers to less than 200 nm, counterintuitive NGA phenomen...

journal_title：Nature communications

authors： Krause S,Bon V,Senkovska I,Többens DM,Wallacher D,Pillai RS,Maurin G,Kaskel S

更新日期：2018-04-20 00:00:00

abstract：:Bacterial contamination of biological channels, catheters or water resources is a major threat to public health, which can be amplified by the ability of bacteria to swim upstream. The mechanisms of this 'rheotaxis', the reorientation with respect to flow gradients, are still poorly understood. Here, we follow individ...

journal_title：Nature communications

authors： Mathijssen AJTM,Figueroa-Morales N,Junot G,Clément É,Lindner A,Zöttl A

更新日期：2019-07-31 00:00:00

abstract：:Because the surface-to-volume ratio of quasi-two-dimensional materials is extremely high, understanding their surface characteristics is crucial for practically controlling their intrinsic properties and fabricating p-type and n-type layered semiconductors. Van der Waals crystals are expected to have an inert surface ...

journal_title：Nature communications

authors： Siao MD,Shen WC,Chen RS,Chang ZW,Shih MC,Chiu YP,Cheng CM

更新日期：2018-04-12 00:00:00

abstract：:The design and assembly of artificial protocell consortia displaying dynamical behaviours and systems-based properties are emerging challenges in bottom-up synthetic biology. Cellular processes such as morphogenesis and differentiation rely in part on reaction-diffusion gradients, and the ability to mimic rudimentary ...

journal_title：Nature communications

authors： Tian L,Li M,Patil AJ,Drinkwater BW,Mann S

更新日期：2019-07-25 00:00:00

abstract：:Single-photon counters are single-pixel binary devices that click upon the absorption of a photon but obscure its spectral information, whereas resolving the color of detected photons has been in critical demand for frontier astronomical observation, spectroscopic imaging and wavelength division multiplexed quantum co...

journal_title：Nature communications

authors： Cheng R,Zou CL,Guo X,Wang S,Han X,Tang HX

更新日期：2019-09-10 00:00:00

abstract：:Between the land and ocean, diverse coastal ecosystems transform, store, and transport material. Across these interfaces, the dynamic exchange of energy and matter is driven by hydrological and hydrodynamic processes such as river and groundwater discharge, tides, waves, and storms. These dynamics regulate ecosystem f...

journal_title：Nature communications

authors： Ward ND,Megonigal JP,Bond-Lamberty B,Bailey VL,Butman D,Canuel EA,Diefenderfer H,Ganju NK,Goñi MA,Graham EB,Hopkinson CS,Khangaonkar T,Langley JA,McDowell NG,Myers-Pigg AN,Neumann RB,Osburn CL,Price RM,Rowland J,Sen

更新日期：2020-05-18 00:00:00

abstract：:Human endogenous retroviruses (HERV) form a substantial part of the human genome, but mostly remain transcriptionally silent under strict epigenetic regulation, yet can potentially be reactivated by malignant transformation or epigenetic therapies. Here, we evaluate the potential for T cell recognition of HERV element...

journal_title：Nature communications

authors： Saini SK,Ørskov AD,Bjerregaard AM,Unnikrishnan A,Holmberg-Thydén S,Borch A,Jensen KV,Anande G,Bentzen AK,Marquard AM,Tamhane T,Treppendahl MB,Gang AO,Dufva IH,Szallasi Z,Ternette N,Pedersen AG,Eklund AC,Pimanda J,Gr

更新日期：2020-11-09 00:00:00

abstract：:Leaves lose approximately 400 H2O molecules for every 1 CO2 gained during photosynthesis. Most long-distance water transport in plants, or xylem sap flow, serves to replace this water to prevent desiccation. Theory predicts that the largest vessels contribute disproportionately to overall sap flow because flow in pipe...

journal_title：Nature communications

authors： Bouda M,Windt CW,McElrone AJ,Brodersen CR

更新日期：2019-12-10 00:00:00

abstract：:DNA methylation maintenance by DNMT1 is an essential process in mammals but molecular mechanisms connecting DNA methylation patterns and enzyme activity remain elusive. Here, we systematically analyzed the specificity of DNMT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1...

journal_title：Nature communications

authors： Adam S,Anteneh H,Hornisch M,Wagner V,Lu J,Radde NE,Bashtrykov P,Song J,Jeltsch A

更新日期：2020-07-24 00:00:00

abstract：:Telomere maintenance is a universal hallmark of cancer. Most tumors including low-grade oligodendrogliomas use telomerase reverse transcriptase (TERT) expression for telomere maintenance while astrocytomas use the alternative lengthening of telomeres (ALT) pathway. Although TERT and ALT are hallmarks of tumor prolifer...

journal_title：Nature communications

authors： Viswanath P,Batsios G,Mukherjee J,Gillespie AM,Larson PEZ,Luchman HA,Phillips JJ,Costello JF,Pieper RO,Ronen SM

更新日期：2021-01-04 00:00:00

abstract：:It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction...

journal_title：Nature communications

authors： Robinson JE,Paluch J,Dickman DK,Joiner WJ

更新日期：2016-01-27 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...

journal_title：Nature communications

authors： Arthur SE,Jiang A,Grande BM,Alcaide M,Cojocaru R,Rushton CK,Mottok A,Hilton LK,Lat PK,Zhao EY,Culibrk L,Ennishi D,Jessa S,Chong L,Thomas N,Pararajalingam P,Meissner B,Boyle M,Davidson J,Bushell KR,Lai D,Farinha

更新日期：2018-10-01 00:00:00

abstract：:Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocaine triggers reprogr...

journal_title：Nature communications

authors： Brami-Cherrier K,Lewis RG,Cervantes M,Liu Y,Tognini P,Baldi P,Sassone-Corsi P,Borrelli E

更新日期：2020-09-07 00:00:00