Abstract:
:Estrone (E1)-sulfatase and dehydroepiandrosterone (DHEA)-sulfatase activities were studied in human female epidermis. Skin specimens were obtained by abdominal or plantar biopsies. The apparent Michaelis-Menten constants for E1 and DHEA sulfatases were 35.2 microM and 8.7 microM, respectively. A substrate inhibition was only observed for DHEA sulfatase. Both sulfatases had an elevated temperature optimum (65 degrees C). The effect of inorganic salts was also tested. In normal epidermis, E1-sulfatase activity was constantly higher than DHEA-sulfatase activity, but no correlation between these activities was observed. On the other hand, E1- and DHEA-sulfatase activities were lower in plantar than in abdominal epidermis. In plantar epidermis of palmoplantar keratoderma, large variations in E1-sulfatase activity, but no significant variation in DHEA-sulfatase activity, were observed. In human epidermis, the findings were consistent with the existence of two different sulfatases: E1 sulfatase and DHEA sulfatase. It would also appear that sulfatase activities are not linked to the abnormal shedding of plantar stratum corneum in palmoplantar keratoderma.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Prost O,Nicollier M,Laurent R,Adessi GLdoi
10.1007/BF00404316subject
Has Abstractpub_date
1985-01-01 00:00:00pages
195-200issue
3eissn
0340-3696issn
1432-069Xjournal_volume
277pub_type
杂志文章abstract::This study concerns 57 patients who fulfilled histological criteria for the diagnosis allergic vasculitis. For 37 of these patients, biopsy specimen were available from lesional and adjacent non-lesional skin. Histological signs of vasculitis were found at both sites, but in clinically normal skin the perivascular inf...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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更新日期:1983-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
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journal_title:Archives of dermatological research
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doi:10.1007/s00403-008-0863-0
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1334-9
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00427657
更新日期:1989-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00376614
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1485-3
更新日期:2014-10-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
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更新日期:1982-01-01 00:00:00
abstract::Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated exp...
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pub_type: 杂志文章,评审
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