Abstract：
:Skin lesions of three patients with inflammatory linear verrucose epidermal naevus (ILVEN) were examined. Histologically, orthokeratosis and parakeratosis were alternately seen in the acanthotic epidermis. By N-(7-dimethylamino-4-methyl-3-coumarinyl)maleimide staining, the horny cells in the parakeratotic epidermis showed a cytoplasmic SH pattern and a weak membranous SS pattern. The orthokeratotic epidermis revealed an increased involucrin expression, whereas the parakeratotic epidermis showed almost no involucrin expression. Ultrastructurally, in the parakeratotic epidermis, the living keratinocytes had prominent Golgi apparatuses and vesicles in the cytoplasm. In the intercellular spaces in the upper spinous layer through to the lower horny layer, an electron dense, homogeneous substance was deposited. The cytoplasm of the horny cells was filled with keratin filaments and contained remnants of nucleus and cytoplasmic membrane structures, and some lipid droplets. The marginal band formation was incomplete. Most of these ultrastructural abnormalities were not found in the orthokeratotic epidermis. There are both similarities and differences in histopathogenesis of the parakeratotic epidermis between ILVEN and psoriasis. A unique finding was the lack of involucrin expression in the ILVEN parakeratotic epidermis.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Ito M,Shimizu N,Fujiwara H,Maruyama T,Tezuka Mdoi
10.1007/BF00371921subject
Has Abstractpub_date
1991-01-01 00:00:00pages
491-9issue
8eissn
0340-3696issn
1432-069Xjournal_volume
283pub_type
杂志文章abstract：:Paraneoplastic pemphigus patients (PNP) develop a group of autoantibodies, among which those against envoplakin and periplakin are almost always found. Epitope mapping has indicated that the linker subdomains of the proteins harbor the major antigenic sites recognized by PNP sera. In order to detect specific autoantib...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0901-y
更新日期：2009-10-01 00:00:00
abstract：:This study focused on the association between plaque psoriasis and polymorphisms of several inflammation genes. Included in the study were 142 Caucasian (Czech) patients with plaque psoriasis and 141 healthy subjects. The genotypes of the polymorphisms in angiotensinogen [M235T ATG, A(-6)G ATG], in transporters associ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000176
更新日期：2000-11-01 00:00:00
abstract：:Role of neurotrophic factors including nerve growth factor (NGF) in the mechanism of overgrowth and hypersensitivity of sensory nerve in atopic dermatitis (AD) has been proposed. Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic factors of the nervous systems; however, the role of GDNF in ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0856-z
更新日期：2008-08-01 00:00:00
abstract：:An increase in phosphodiesterase 4 (PDE4) in blood mononuclear white cells of patients with atopic dermatitis (AD) has been described. This and other skin disorders worsen during stress, during which there are increased circulating levels of adrenaline and glucocorticoids. The aim of this study was to analyse the effe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0313-3
更新日期：2002-07-01 00:00:00
abstract：:As the main nitrogen source in Malassezia furfur, tryptophan induces the formation of fluorochromes and pigments, which make the yeast less sensitive to UV light. To detect a chemical UV filter, M. furfur (CBS 1878) was incubated at 30 degrees C for 14 days on a pigment-inducing medium and agar extracts were purified ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0294-2
更新日期：2002-05-01 00:00:00
abstract：:Survivin, a member of the inhibitors of apoptosis protein family, regulates both cellular proliferation and apoptotic cell death. While the human survivin gene is highly expressed in the developing fetus, in adults its expression is restricted to highly proliferating normal tissues and neoplastic tumors tissues. In th...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0572-x
更新日期：2005-07-01 00:00:00
abstract：:Transcutaneous oxygen pressure (TcPO2) and skin blood flow (as evaluated by laser doppler) (LD) were investigated in 24 systemic sclerosis (SSc) patients in sclerotic skin (dorsal aspect of the hand) and non-sclerotic skin (interscapular region) and in 24 controls matched for sex and age for the same sites. The two pa...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00376614
更新日期：1991-01-01 00:00:00
abstract：:Primary hyperhidrosis is a condition characterized by excessive sweating. The estimated prevalence is between 0.6 and 4.4%, and it can have economic, psychological, and social consequences for affected individuals. Family and genetic studies have suggested a genetic component in the inheritance of the disease. In this...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-019-01966-1
更新日期：2019-12-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694624
更新日期：1979-10-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00493466
更新日期：1990-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01939-4
更新日期：2019-10-01 00:00:00
abstract：:The demonstration of cytokine mRNA expression in epidermal cells by the polymerase chain reaction technique preceded by reverse transcription (RT-PCR) requires linear test conditions (i.e. that the product obtained after amplification reflects the relative amounts of starting material) and high reproducibility, specif...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00370722
更新日期：1994-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030100257
更新日期：2001-09-01 00:00:00
abstract：:In 1901, Hans Vörner observed a family with a diffuse non-transgredient palmoplantar keratoderma of autosomal dominant inheritance. Histopathologically, he found epidermolytic hyperkeratosis as a characteristic sign and diagnostic criterion of this disorder. We performed a follow-up study of the family originally seen...
journal_title：Archives of dermatological research
pub_type： 历史文章,杂志文章
doi：10.1007/s00403-002-0328-9
更新日期：2002-08-01 00:00:00
abstract：:Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and VI, fibronectin and ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00373353
更新日期：1993-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-019-01991-0
更新日期：2020-07-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02096-9
更新日期：2020-07-28 00:00:00
abstract：:The composition of the aerobic and anaerobic bacterial skin flora was investigated quantitatively and qualitatively in 25 patients with seborrheic eczema (SE) and in 35 healthy persons. In SE patients, the geometric mean count for propionibacteria in the pilosebaceous ducts of the forehead was reduced to a statistical...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404292
更新日期：1980-01-01 00:00:00
abstract：:Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atheroge...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01896-y
更新日期：2019-05-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02507101
更新日期：1996-06-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1503-5
更新日期：2014-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371599
更新日期：1993-01-01 00:00:00
abstract：:Six patients with delayed pressure urticaria (DPU) applied clobetasol propionate (0.05%) ointment or its base to predetermined test sites on the right and left thigh as part of a randomized, double-blind study. A pressure challenge was administered to each test site at the initial visit and repeated after 3 days and 6...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01105080
更新日期：1995-01-01 00:00:00
abstract：:Three new cromones have been studied that are supposed to be better absorbed and to have a wider spectrum of anti-allergic activity than disodium cromoglycate. Pretreatment with i.d. injection of 10 microgram FPL 52758 significantly reduced the weal and flare reaction induced by specific antigen in 11 patients with at...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00403843
更新日期：1980-01-01 00:00:00
abstract：:Photodynamic therapy (PDT) in dermatology has been proven to be a successful noninvasive therapeutic modality for treating skin cancer. To facilitate its clinical introduction, the development of topical photosensitizers is necessary to avoid generalized, cutaneous photosensitivity. Therefore the penetration of synthe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050168
更新日期：1997-02-01 00:00:00
abstract：:An ultrastructural investigation of two cutaneous lesions in a two-year-old Turkish boy with disseminated lipogranulomatosis (Farber) revealed curvilinear bodies in fibroblasts, histiocytes, and endothelial cells; "elongated membranes" in fibroblasts and endothelial cells; "zebra bodies" in endothelial cells; and spin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694628
更新日期：1979-10-01 00:00:00
abstract：:Six cases of dermatofibrosarcoma protuberans were studied ultrastructurally. Biopsy material from all six cases as well as cell cultures derived from four cases were examined. In all cases, the tumor cells in vivo and in vitro were related to fibroblasts. The two cases with histiocytoid features and a small spiral pat...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409221
更新日期：1985-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00408223
更新日期：1981-01-01 00:00:00
abstract：:Solar radiation in the UVB range is absorbed primarily by the epidermal DNA where characteristic photodamage results in altered immune responses and mutagenic lesions. UVB exposure of the skin results in a profound upregulation of the anti-inflammatory cytokine, IL-10 and suppression of contact hypersensitivity (CHS)....
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0634-0
更新日期：2006-03-01 00:00:00
abstract：:The use of underarm cosmetics is common practice in the Western society to obtain better body odor and/or to prevent excessive sweating. A survey indicated that 95 % of the young adult Belgians generally use an underarm deodorant or antiperspirant. The effect of deodorants and antiperspirants on the axillary bacterial...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1487-1
更新日期：2014-10-01 00:00:00
