Abstract：
:Solar radiation in the UVB range is absorbed primarily by the epidermal DNA where characteristic photodamage results in altered immune responses and mutagenic lesions. UVB exposure of the skin results in a profound upregulation of the anti-inflammatory cytokine, IL-10 and suppression of contact hypersensitivity (CHS). Given that IL-10 is produced after UVB exposure, and that antibodies against IL-10 have been shown to reverse UVB-induced immune suppression, we hypothesized that IL-10 transgenic mice would show an enhanced immune suppression in response to UVB. Using an IL-10 transgenic mouse model (IL-10tg), we examined the CHS response in unexposed animals and those exposed to UVB. Unexposed IL-10tg animals showed a diminished CHS response compared to wild-type. Surprisingly, however, when IL-10tg animals were exposed to UVB, the CHS response was not further suppressed, but rather was restored to the level observed in unexposed wild-type animals.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Ma LJ,Guzmán EA,DeGuzman A,Walter B,Muller HK,Walker AM,Owen LBdoi
10.1007/s00403-005-0634-0keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
417-20issue
9eissn
0340-3696issn
1432-069Xjournal_volume
297pub_type
杂志文章abstract：:In preparations of papillary dermis taken from clinically normal skin of patients with dermatitis herpetiformis (DH), the disappearance of granular IgA deposits induced by peptic digestion was partial at pH 4.5 and total at pH 4.1, as visualized by immunofluorescence microscopy. In a model system in which human monome...
journal_title：Archives of dermatological research
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abstract：:Costimulation of anti-CD3-triggered proliferative T-cell responses by type I and type IV collagen and fibronectin was studied in 25 patients with psoriasis and 12 healthy subjects. The stimulation index of anti-CD3-mediated responses in the presence of type I collagen was about half that in the controls. Although the ...
journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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doi：10.1007/s00403-015-1581-z
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journal_title：Archives of dermatological research
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doi：10.1007/s00403-014-1494-2
更新日期：2014-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412863
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412930
更新日期：1986-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1291-8
更新日期：2012-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403801
更新日期：1980-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00413358
更新日期：1984-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000160
更新日期：2000-09-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412927
更新日期：1986-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050408
更新日期：1999-05-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00585921
更新日期：1987-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
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更新日期：2013-07-01 00:00:00
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journal_title：Archives of dermatological research
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pub_type： 杂志文章
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更新日期：2020-11-22 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00413357
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：1987-01-01 00:00:00
abstract：:Circulating and in situ mononuclear cell subsets were phenotypically characterized during both the acute and convalescent phase of herpes zoster infections in 14 patients. In peripheral blood a significant reduction in the absolute number of Leu 4+ T cells, Leu 2a+ suppressor/cytotoxic T cells, Leu 3a+ helper/inducer ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412622
更新日期：1987-01-01 00:00:00
