Abstract:
:Survivin, a member of the inhibitors of apoptosis protein family, regulates both cellular proliferation and apoptotic cell death. While the human survivin gene is highly expressed in the developing fetus, in adults its expression is restricted to highly proliferating normal tissues and neoplastic tumors tissues. In the present study, we compared the expression of survivin in melanoma and benign melanocytic lesions such as junctional, compound, dermal, congenital, blue and spitz nevi. This analysis reveals a heterogeneous expression of survivin with respect to both the intensity, frequency and cellular localization. In junctional, compound and blue nevi, survivin was present in nuclear localization, whereas in spitz nevi survivin was detectable in the cytoplasm. In dermal and congenital nevi, survivin was present in both localizations with predominance of the nuclear compartment. Interestingly, this distribution was similar to that observed in primary melanoma; whereas in metastatic melanoma the predominance of the nuclear localization of survivin was lost. Our data demonstrate that although survivin is expressed in a large number of benign nevi, the balance between its cytoplasmic and nuclear expression was immensely heterogeneous between lesions with suspected different developmental origins.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Vetter CS,Müller-Blech K,Schrama D,Bröcker EB,Becker JCdoi
10.1007/s00403-005-0572-xkeywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
26-30issue
1eissn
0340-3696issn
1432-069Xjournal_volume
297pub_type
杂志文章abstract::The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1681-4
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abstract::Recently, medium-dose UVA1 phototherapy (50 J/cm2) has been introduced as an effective treatment for severe atopic dermatitis (AD). In order to further elucidate the mechanisms by which medium-dose UVA1 irradiation leads to an improvement in skin status in patients with AD, biopsy specimens from ten patients before an...
journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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doi:10.1007/s00403-011-1177-1
更新日期:2012-03-01 00:00:00
abstract::The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) in the reconstruction of skin equivalent (SE). H&E staining showed that SE containing hyaluronic acid (HA) or HA and CCC had a thicker epidermis than the control SE. Immunohistochemical staining showed that p63 was mainly present at the b...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1283-8
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abstract::Delayed pressure urticaria (DPU) is characterized by deep dermal wheals that appear in response to a local continuous pressure. Although it has been reported to complicate as many as 40% of cases of Caucasian patients with chronic urticaria, no definitive cases of Asian/Japanese patients have been reported in English ...
journal_title:Archives of dermatological research
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abstract::A recently described endogenous proteolytic process in pieces of human plantar stratum corneum incubated in vitro has been further studied. This process leads to a decrease in cohesion between the cells that had been facing outwards in vivo. Using two methods, that differed with respect to efficiency, to detach surfac...
journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403728
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journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00455372
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-007-0747-8
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1654-7
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journal_title:Archives of dermatological research
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doi:10.1007/s00403-008-0909-3
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journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Archives of dermatological research
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pub_type: 杂志文章
doi:10.1007/BF00373353
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00409221
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0583-7
更新日期:2005-09-01 00:00:00
abstract::This study determines if the anatomic region affected percutaneous absorption in the rhesus monkey, an animal model with some relevance to man. Percutaneous absorption of testosterone (13.3 microgram/cm2) from the ventral forearm was 8.8 +/- 2.5%. Absorption from the chest was slightly less (5.3 +/- 0.6%) while that f...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403844
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-004-0495-y
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abstract::We conducted a nationwide record-linked study using all English NHS hospital admission data and mortality statistics from 1999 to 2011 to evaluate the risk of concurrent or subsequent bullous pemphigoid (BP) in a cohort of 2,873,720 individuals with malignant cancers, when compared with a reference cohort. We calculat...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1399-5
更新日期:2014-01-01 00:00:00
abstract::Recently, we reported that UVB-activated indole-3-acetic acid (IAA) induces the apoptosis of G361 human melanoma cells. In the present study, we used IAA and visible light combinations to treat B16F10 melanoma-implanted nude mice using an experimental intense pulsed light (IPL) therapy model. We first investigated whe...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-0938-6
更新日期:2009-04-01 00:00:00