Distribution of apoptosis-mediating Fas antigen in human skin and effects of anti-Fas monoclonal antibody on human epidermal keratinocyte and squamous cell carcinoma cell lines.

abstract：:Polymorphonuclear leukocytes from patients with psoriasis demonstrated a significantly enhanced chemotactic responsiveness to zymosan-activated human serum as compared to granulocytes from healthy volunteers. Furthermore, psoriatic peripheral blood mononuclear cells stimulated with concanavalin a produced an increased...

journal_title：Archives of dermatological research

authors： Csató M,Dobozy A,Hunyadi J,Kenderessy SA,Simon N

更新日期：1981-01-01 00:00:00

abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects the patients' quality of life greatly often from a very young age. Its worldwide incidence in children and adults varies, but it is usually among the first ten causes of dermatological consultation worldwide. There is a wide variety of treatmen...

journal_title：Archives of dermatological research

authors： de María Díaz Granados L,Quijano MA,Ramírez PA,Aguirre N,Sanclemente G

更新日期：2018-01-01 00:00:00

abstract：:Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...

journal_title：Archives of dermatological research

authors： Boudhraa Z,Merle C,Mazzocut D,Chezal JM,Chambon C,Miot-Noirault E,Theisen M,Bouchon B,Degoul F

更新日期：2014-12-01 00:00:00

abstract：:The dermal papilla plays pivotal roles in hair follicle cycle and dermal papilla cells (DPCs) with aggregative behavior have more obviously inductive ability. In the present study, the suppression subtractive hybridization method was employed to identify the differentially expressed genes in dermal papillae cells with...

journal_title：Archives of dermatological research

authors： Zhiqiang S,Jiwen W,Fei H,Weibin Y,Feng Z,Xichuan Y,Chunlan L

更新日期：2005-09-01 00:00:00

abstract：:This study was designed to investigate the effects of griseofulvin, 5-fluorocytosine (5-FC), and amphotericin B on pancreatic and gastric secretion after the administration of a single large dose, or repeated small doses for 3 weeks, in male albino rats. The exocrine functions of the main digestive glands were only sl...

journal_title：Archives of dermatological research

authors： Park YK,Lee S,Kim WJ,Hong SS

更新日期：1979-10-01 00:00:00

abstract：:Skin lesions of three patients with inflammatory linear verrucose epidermal naevus (ILVEN) were examined. Histologically, orthokeratosis and parakeratosis were alternately seen in the acanthotic epidermis. By N-(7-dimethylamino-4-methyl-3-coumarinyl)maleimide staining, the horny cells in the parakeratotic epidermis sh...

journal_title：Archives of dermatological research

authors： Ito M,Shimizu N,Fujiwara H,Maruyama T,Tezuka M

更新日期：1991-01-01 00:00:00

abstract：:Genetic abnormalities for different subtypes of epidermolysis bullosa (EB) have been described. In dominant simplex type EB, mutations of the K5 or K14 gene lead to disruption of basal cells and the formation of bullae. The recessive simplex types include EB with muscular dystrophy due to abnormal plectin, EB without ...

journal_title：Archives of dermatological research

authors： Mitsuhashi Y,Hashimoto I

更新日期：2003-04-01 00:00:00

abstract：:Three per cent boric acid incorporated in an anhydrous, water-emulsifying ointment causes no increase of boron levels in blood and urine during a period of 1-9 days after a single topical application. The same amount of boric acid incorporated in a water-based jelly does cause an increase in blood and urine levels, be...

journal_title：Archives of dermatological research

authors： Stüttgen G,Siebel T,Aggerbeck B

更新日期：1982-01-01 00:00:00

abstract：:An ultrastructural study of the skin lesion of a young patient affected by pseudo-Kaposi's sarcoma of the Bluefarb-Stewart type (BSS) is reported. The neoplasm consisted of a proliferation of vascular structures mostly consisting of a solid bud of endothelial cells surrounded by a thinned and polystratified basement m...

journal_title：Archives of dermatological research

authors： Fimiani M,Simoni S,Miracco C,De Santi M,Luzi P,Andreassi L

更新日期：1989-01-01 00:00:00

abstract：:The stimulation or inhibition of adenylate cyclase by hormones and chemicals is mediated by the stimulatory or inhibitory guanine nucleotide-binding proteins, Gs and Gi respectively. Although the presence of these G-proteins in the epidermis has been suggested, no direct information regarding their nature has been ava...

journal_title：Archives of dermatological research

authors： Takahashi H,Miyokawa N,Katagiri M,Iizuka H

更新日期：1990-01-01 00:00:00

abstract：:The effects of acidic and basic fibroblast growth factors (aFGF and bFGF, respectively) on proliferation and differentiation of cultured hair apparatus cells were examined using bovine pituitary extract (BPE)-free media. The importance of FGFs as growth factors in BPE was also examined. Both FGFs and BPE stimulated ce...

journal_title：Archives of dermatological research

authors： Tanigaki-Obana N,Ito M

更新日期：1994-01-01 00:00:00

abstract：:The phospholipids of the skin are difficult to quantify because they represent only a small fraction of the skin tissue. In this study, 31P nuclear magnetic resonance, which permits precise profiling of these phospholipids, was used to compare the phospholipids of upper eyelid epidermal and dermal lipid extracts (n = ...

journal_title：Archives of dermatological research

authors： Greiner JV,Glonek T,Townsend DJ,Hearn SL

更新日期：1998-06-01 00:00:00

abstract：:The history of 188 caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the a...

journal_title：Archives of dermatological research

authors： Küster W,Petersen M,Christophers E,Goos M,Sterry W

更新日期：1990-01-01 00:00:00

abstract：:Six cases of dermatofibrosarcoma protuberans were studied ultrastructurally. Biopsy material from all six cases as well as cell cultures derived from four cases were examined. In all cases, the tumor cells in vivo and in vitro were related to fibroblasts. The two cases with histiocytoid features and a small spiral pat...

journal_title：Archives of dermatological research

authors： Schmoeckel C,Albini A,Krieg T,Stets R

更新日期：1985-01-01 00:00:00

abstract：:1. Suction blisters on the skin of rats, obtained with a negative pressure of 150 mm Hg, show a close similarity to human suction blisters, based on histological, electrolyte and protein findings. 2. Pharmacokinetic experiments with inulin and antipyrine have proved that the movement of these low protein binding drugs...

journal_title：Archives of dermatological research

authors： Herfst MJ,van Rees H

更新日期：1978-12-01 00:00:00

abstract：:Stress is a well-known triggering factor along with genetic predisposition on the onset and during the course of psoriasis by altering the cellular constituents of the immune system. In the skin, there is a local hypothalamic-pituitary-adrenal (HPA) axis which is the equivalent of the central HPA axis. Corticotropin-r...

journal_title：Archives of dermatological research

authors： Cemil BC,Canpolat F,Yilmazer D,Eskioğlu F,Alper M

更新日期：2012-03-01 00:00:00

abstract：:Atopic dermatitis (AD) is a frequent and burdensome disease. The objectives of this study were (1) to assess the willingness to pay (WTP) and quality of life (Qol) in AD patients and (2) to compare the results with data on other chronic skin diseases. To collect data, a non-interventional, cross-sectional nationwide p...

journal_title：Archives of dermatological research

authors： Beikert FC,Langenbruch AK,Radtke MA,Kornek T,Purwins S,Augustin M

更新日期：2014-04-01 00:00:00

abstract：:It is known that eosinophils are actively involved in allergy and inflammation. The granular components of eosinophils, eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin/eosinophil protein X (EDN/EPX), play an important role in such allergic and inflammatory processes. Prurigo nodularis is a chronic ...

journal_title：Archives of dermatological research

authors： Johansson O,Liang Y,Marcusson JA,Reimert CM

更新日期：2000-08-01 00:00:00

abstract：:We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to indu...

journal_title：Archives of dermatological research

authors： Ahn JH,Jin SH,Kang HY

更新日期：2008-07-01 00:00:00

abstract：:Keloid disease (KD) is a quasineoplastic fibroproliferative tumour of unknown origin causing a progressive, recurrent dermal lesion. KD is not homogeneous in nature and shows phenotypic structural differences between its distinct peripheral margins compared to its centre. The keloid margin is often symptomatically mor...

journal_title：Archives of dermatological research

authors： Hollywood KA,Maatje M,Shadi IT,Henderson A,McGrouther DA,Goodacre R,Bayat A

更新日期：2010-12-01 00:00:00

abstract：:The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...

journal_title：Archives of dermatological research

authors： Leo MS,Sivamani RK

更新日期：2014-12-01 00:00:00

abstract：:Because of its easy accessibility, the skin is a very attractive target for gene therapy purposes. To study potential clinical applications in a preclinical setting, appropriate animal models are needed. Pig skin is very similar to human skin, and a variety of human diseases that are potentially amenable to gene thera...

journal_title：Archives of dermatological research

authors： Pfützner W,Joari MR,Foster RA,Vogel JC

更新日期：2006-06-01 00:00:00

abstract：:Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...

journal_title：Archives of dermatological research

authors： Goulart IM,Goulart LR

更新日期：2008-07-01 00:00:00

abstract：:Ionotrope glutamate receptors of the N-methyl-D-aspartate (NMDA) receptor type are expressed on keratinocytes and influence the intracellular calcium concentration. The importance of NMDA receptors in pathophysiological processes in the skin is, however, still unclear. Epidermal distribution patterns of NMDA receptors...

journal_title：Archives of dermatological research

authors： Fischer M,William T,Helmbold P,Wohlrab J,Marsch WCh

更新日期：2004-09-01 00:00:00

abstract：:The skin is the major site on anaphylaxis, and cutaneous mast cells have an important role in its reactions. The isolation and purification of rat cutaneous mast cells are described here. Rat abdominal skin was digested with collagenase and hyaluronidase, and centrifuged with Percoll. The buoyant density of cutaneous ...

journal_title：Archives of dermatological research

authors： Hachisuka H,Kusuhara M,Higuchi M,Okubo K,Sasai Y

更新日期：1988-01-01 00:00:00

abstract：:Nickel, cobalt and chromium are metals very often implicated in allergic contact dermatitis. In vivo, keratinocytes, which are the first target cells, can be directly activated to participate in the local reaction, especially through the expression of the membrane antigen ICAM-1, a ligand of the leucocyte antigen LFA-...

journal_title：Archives of dermatological research

authors： Guéniche A,Viac J,Lizard G,Charveron M,Schmitt D

更新日期：1994-01-01 00:00:00

abstract：:Angiosarcoma, a malignant tumor of vascular endothelial cell origin, is a lethal disease for which complete cure is rarely seen. The objective of this study was to determine the efficiency of photodynamic therapy (PDT) as a new treatment for angiosarcoma. PDT (630 nm, 25 J/cm2) using Photofrin for a mouse angiosarcoma...

journal_title：Archives of dermatological research

authors： Jin I,Yuji M,Yoshinori N,Makoto K,Mikio M

更新日期：2008-04-01 00:00:00

abstract：:Female hairless mice (strain mutant hr/hr) have been irradiated with increasing doses of UV-B over a period of 4 weeks. They were compared with untreated controls Additional groups of 30 mice were treated with milk base or cream base or milk SPF6 or cream SPF6 or cream SPF8 daily before irradiation. No changes of body...

journal_title：Archives of dermatological research

authors： Vogel HG,Alpermann HG,Futterer E

更新日期：1981-01-01 00:00:00

abstract：:A novel point mutation in a patient with vascular type Ehlers-Danlos syndrome is herein reported. The patient experienced pneumothorax and multiple arterial troubles during the past 10 years. The patient's hand skin was atrophic, and a paper-like atrophic scar was seen. The collagen microfibrils from the patient's ski...

journal_title：Archives of dermatological research

authors： Okamoto O,Ando T,Watanabe A,Sato F,Mimata H,Shimada T,Fujiwara S

更新日期：2008-10-01 00:00:00

abstract：:A monoclonal antibody (Ted-R-1) to the keratohyalin granules (KHGs) of the newborn rat epidermis was developed by immunizing mice with a pH 4.7 hematoxylin-stainable fraction of the extract in a 50 mM Tris-HCl buffer, pH 7.3, containing 10 micrograms/ml phenylmethylsulfonyl fluoride (PMSF) from the newborn rat whole e...

journal_title：Archives of dermatological research

authors： Tezuka T,Takahashi M

更新日期：1989-01-01 00:00:00