Abstract：
:The skin is the major site on anaphylaxis, and cutaneous mast cells have an important role in its reactions. The isolation and purification of rat cutaneous mast cells are described here. Rat abdominal skin was digested with collagenase and hyaluronidase, and centrifuged with Percoll. The buoyant density of cutaneous mast cells was high, and relatively pure mast cells were obtained. The purity of cutaneous mast cells was 74% +/- 2.4% before and 50.0% +/- 6.4% after Percoll density centrifugation; peritoneal mast cells revealed 5.8% +/- 1.3% purity before and 61.0% +/-10.6% purity after the same procedure. The isolated cutaneous cells released 21.3% +/- 3.8% histamine and the peritoneal mast cells released 55.5% +/- 3.8% histamine upon stimulation with 10 micrograms/ml compound 48/80. These findings suggest that there are functional subsets of connective tissue mast cells.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Hachisuka H,Kusuhara M,Higuchi M,Okubo K,Sasai Ydoi
10.1007/BF00426614subject
Has Abstractpub_date
1988-01-01 00:00:00pages
358-62issue
6eissn
0340-3696issn
1432-069Xjournal_volume
280pub_type
杂志文章abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1581-z
更新日期：2015-08-01 00:00:00
abstract：:Keloid is a complex condition with environmental and genetic risk-contributing factors. Two candidate genes, TGFβ1 and SMAD4, located in the same signaling pathway are highly expressed in the keloid fibroblast cells. In a case-control design, TGFβ1 haplotypes showed association with the risk of keloid in the present s...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1262-0
更新日期：2012-09-01 00:00:00
abstract：:A 61-year old woman developed a tumourous nodule in her left leg. Fifteen years ago a similar tumour had been removed in the same localization. Histological examination performed on biopsy material showed bundles of predominantly fusiform tumour cells with nuclear pleomorphism and many mitotic figures. Electron micros...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00446437
更新日期：1978-11-10 00:00:00
abstract：:GM-CSF is known primarily as a hematopoietic growth factor, but it has also been shown to inhibit mast cell differentiation in vitro. In order elucidate the mechanisms involved, we investigated the effects of GM-CSF in vitro on the differentiation of human leukemic mast cells (HMC-1 cells) and normal cord blood-derive...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030100225
更新日期：2001-05-01 00:00:00
abstract：:Abnormal dermal deposition of elastic fibers is the earliest and most striking effect of prolonged sun exposure (solar elastosis). The hyperplastic fibers are usually ascribed to ultraviolet (UV) rays. Nonetheless, other portions of the solar spectrum may play contributing roles. Heat, for example, enhances experiment...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00509050
更新日期：1982-01-01 00:00:00
abstract：:No previous studies have convincingly linked sweating disturbance with the subsequent development of lichen planus (LP). Therefore, we investigated whether sweating disturbance could be specifically detected in LP lesions and how it could trigger lesion development. We utilized the impression mold technique (IMT), whi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1882-0
更新日期：2019-01-01 00:00:00
abstract：:Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0889-3
更新日期：2009-01-01 00:00:00
abstract：:Mice homozygous for three different recessive mutations known to cause pleiotropic defects in the immune system and in the skin were used to evaluate the relationship between the classical immune system and dendritic epidermal cell populations. Numbers of Langerhans cells (LCs) and Thy-1+ dendritic cells (Thy-1+DEC) w...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372621
更新日期：1990-01-01 00:00:00
abstract：:Using the sebum-absorbent tape technique, we have disclosed five different patterns of follicular sebum excretion rate (SER). These are the infantile, pubertal, acne, adult and aging patterns, distinguished by different densities of active sebaceous follicles, by distinct levels of follicular SER and by the relative s...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00585931
更新日期：1987-01-01 00:00:00
abstract：:Costimulation of anti-CD3-triggered proliferative T-cell responses by type I and type IV collagen and fibronectin was studied in 25 patients with psoriasis and 12 healthy subjects. The stimulation index of anti-CD3-mediated responses in the presence of type I collagen was about half that in the controls. Although the ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01262328
更新日期：1995-01-01 00:00:00
abstract：:Heparin-binding EGF-like growth factor (HB-EGF) and amphiregulin (AREG) are the members of EGF family that bind to common EGF receptor (EGFR) in the epidermis. However, the role of these two growth factors in epidermal hyperplasia of psoriasis has not been established. On the other hand, CD4+ T cells are responsible f...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-007-0809-y
更新日期：2008-01-01 00:00:00
abstract：:Recently, we described a novel fibroblast-restricted monoclonal antibody (mAb AS02) that recognizes a membrane-bound antigen. Characterization and isolation of the corresponding antigen showed that mAb AS02 recognized a protein on human fibroblasts that is highly homologous or identical to human Thy-1 antigen (CD90). ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050318
更新日期：1998-07-01 00:00:00
abstract：:Glycerol, widely used as humectant, is known to protect against irritants and to accelerate recovery of irritated skin. However, most studies were done with topical formulations (i.e. emulsions) containing glycerol in relatively high amounts, preventing drawing conclusions from direct effects. In this study, acute che...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-1021-z
更新日期：2010-08-01 00:00:00
abstract：:Sixteen malignant melanoma patients with different levels of tumor progression, two patients with melanoma in situ (Clark 10 two bronchogenic carcinoma patients and nine healthy controls were tested by means of the leukocyte adherence inhibition (LAI) test to assess the function of their cellular mediated immunity. Bl...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403801
更新日期：1980-01-01 00:00:00
abstract：:The expression and location of the Ki-67 antigen was investigated in 62 basal cell carcinomas (BCC) using immunostaining techniques (PAP and APAAP) on cryostat sections. The tumor samples were classified into three groups according to microarchitecture (nodular, superficial or fibrosing). The Ki-67 growth fraction dis...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371599
更新日期：1993-01-01 00:00:00
abstract：:The use of underarm cosmetics is common practice in the Western society to obtain better body odor and/or to prevent excessive sweating. A survey indicated that 95 % of the young adult Belgians generally use an underarm deodorant or antiperspirant. The effect of deodorants and antiperspirants on the axillary bacterial...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1487-1
更新日期：2014-10-01 00:00:00
abstract：:Estrone (E1)-sulfatase and dehydroepiandrosterone (DHEA)-sulfatase activities were studied in human female epidermis. Skin specimens were obtained by abdominal or plantar biopsies. The apparent Michaelis-Menten constants for E1 and DHEA sulfatases were 35.2 microM and 8.7 microM, respectively. A substrate inhibition w...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404316
更新日期：1985-01-01 00:00:00
abstract：:Acrolein and 4-hydroxy-2-nonenal (HNE) are both byproducts of a lipid peroxidation reaction. Actinic elastosis in photodamaged skin of aged individuals is characterized by the accumulation of fragmented elastic fibers in the sun-exposed areas. To study whether a lipid peroxidation reaction is involved in the accumulat...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030100239
更新日期：2001-07-01 00:00:00
abstract：:It has been reported that artificial restoration of barrier function by a water vapor-impermeable membrane after tape stripping induces barrier abrogation in hairless mice, impeding rather than enhancing barrier recovery. To address this issue, we examined the morphologic changes in the epidermis after tape stripping ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050280
更新日期：1998-03-01 00:00:00
abstract：:Keloid disease (KD) is a quasineoplastic fibroproliferative tumour of unknown origin causing a progressive, recurrent dermal lesion. KD is not homogeneous in nature and shows phenotypic structural differences between its distinct peripheral margins compared to its centre. The keloid margin is often symptomatically mor...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1071-2
更新日期：2010-12-01 00:00:00
abstract：:Recently, we reported that UVB-activated indole-3-acetic acid (IAA) induces the apoptosis of G361 human melanoma cells. In the present study, we used IAA and visible light combinations to treat B16F10 melanoma-implanted nude mice using an experimental intense pulsed light (IPL) therapy model. We first investigated whe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0938-6
更新日期：2009-04-01 00:00:00
abstract：:Recently a new thin layer chromatography plate (Whatman LK 6D) became available which is extremely easy to handle and permits highly reproducible qualitative and quantitative analysis. This plate proved to be of great value for the investigation of skin surface lipids. The use of a fatty acid methyl ester as an intern...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412383
更新日期：1979-07-30 00:00:00
abstract：:Botulinum toxin type A (BoNT-A) is an easy and fast treatment for gingival smile (GS). The objective of the study was to compare the reduction of gingival exposure using three different doses of abobotulinumtoxinA (ABO) in patients with different severities of anterior GS, and to assess treatment safety and patients' ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02096-9
更新日期：2020-07-28 00:00:00
abstract：:The dependence of epithelial spread on human serum in culture has been studied. Using measured pieces of mouse ear skin epithelial outgrowth about floating explants (epiboly) and from adherent explants was studied. Where compared directly the two systems show similar results. Because of its ease of quantitation, the a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417274
更新日期：1979-02-23 00:00:00
abstract：:A low-molecular-weight proteinase inhibitor was isolated from human epidermal extracts by means of ultrafiltration, gel filtration and ion-exchange chromatography. On polyacrylamide gel electrophoresis (PAGE), the isolated fraction exhibited a single band of activity at pH 9.4, and inhibitory activity against papain a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412923
更新日期：1986-01-01 00:00:00
abstract：:Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with insulin resistance (IR), metabolic syndrome and increased cardiovascular risk. Adipokines are biologically active, pleotropic molecules which have been involved in the development of IR and in the pathogenesis of several chronic inflammato...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-02018-4
更新日期：2020-10-01 00:00:00
abstract：:Tumor-associated antigens were demonstrated in phenol water extracts of human malignant melanoma by migration tests with leukocytes from melanoma patients and controls: in 25 out of 60 melanoma patients weak reactivity was observed, usually stimulation of leukocyte migration, while leukocytes from 37 controls were neg...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417277
更新日期：1979-02-23 00:00:00
abstract：:We investigated the effects of glucocorticoids on IL-3-dependent proliferation and c-kit expression of cells of the mouse mast cell line, MC/9. Glucocorticoids (dexamethasone, prednisolone, and hydrocortisone) inhibited IL-3-dependent MC/9 cell proliferation, whereas sex steroids (progesterone, beta-estradiol, and tes...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050398
更新日期：1999-04-01 00:00:00
abstract：:Adhesional glycoproteins of desmosomes possess asparagine-linked, complex oligosaccharide side chains. We investigated the potential of these sugars to protect the core proteins of desmosomes and corneosomes (modified stratum corneum desmosomes) against proteolysis. Isolated pig ear epidermis was exposed sequentially ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372058
更新日期：1991-01-01 00:00:00
abstract：:Besides its role in small-cell carcinoma of the lung, elevated serum levels of neuron-specific enolase (NSE) have recently been reported to be associated with autoimmune rheumatic disorders such as systemic sclerosis. Serum NSE seems to correlate with disease activity as well as Rodnan skin score. The aim of the study...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-004-0495-y
更新日期：2004-09-01 00:00:00
