Abstract:
:Costimulation of anti-CD3-triggered proliferative T-cell responses by type I and type IV collagen and fibronectin was studied in 25 patients with psoriasis and 12 healthy subjects. The stimulation index of anti-CD3-mediated responses in the presence of type I collagen was about half that in the controls. Although the CD3-dependent proliferative response of psoriatic lymphocytes in patients with active widespread plaque psoriasis was reduced by about 50%, costimulatory responses induced by type IV collagen and fibronectin were found to be enhanced in relation to the controls. The degree of costimulation by type IV collagen and fibronectin was related to disease severity. The highest values of the stimulation index were found in patients with a PASI greater than 24, skin involvement of more than 40% of body surface area, and a duration of psoriatic lesions of more than 3 months. The results indicated that in active widespread plaque psoriasis subpopulations of T cells bearing receptors for some extracellular matrix proteins were increased in the peripheral blood. A factor responsible for this phenomenon may be trafficking of T cells through the basement membrane zone of psoriatic lesions, which presumably causes modification of T cell immunological responsiveness after recirculation.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Glinski W,Gorski A,Glinska-Ferenz M,Majewski S,Stepien-Sopniewska Bdoi
10.1007/BF01262328subject
Has Abstractpub_date
1995-01-01 00:00:00pages
176-9issue
2eissn
0340-3696issn
1432-069Xjournal_volume
287pub_type
杂志文章abstract::In many skin diseases such as Demodex folliculitis, rosacea- or steroid-induced rosacea Demodex mites are present in abundance and are at least partially held responsible for causing these disorders. Although it is known that these diseases respond well to tetracyclines, it is unclear if this is due to the antiinflamm...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-009-0984-0
更新日期:2009-10-01 00:00:00
abstract::CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-018-1863-3
更新日期:2018-11-01 00:00:00
abstract::Electron microscopic aspects in ten cases of normolipidemic cutaneous xanthomatosis have been investigated. Two additional types IV and V hyperlipoproteinaemic xanthomatosis have also been included. Ultrastructural findings in all cases were similar. Abundant histiocytic cells with numerous intracytoplasmic lipid vacu...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00694624
更新日期:1979-10-01 00:00:00
abstract::The mechanism of action of thalidomide in the treatment of patients with Behçet's disease (BD) is poorly understood. There is some evidence to suggest that certain immunological abnormalities are associated with the pathogenesis of BD. A BD-like mouse model induced by herpes simplex virus (HSV) inoculation shows simil...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-004-0498-8
更新日期:2004-09-01 00:00:00
abstract::Besides its role in small-cell carcinoma of the lung, elevated serum levels of neuron-specific enolase (NSE) have recently been reported to be associated with autoimmune rheumatic disorders such as systemic sclerosis. Serum NSE seems to correlate with disease activity as well as Rodnan skin score. The aim of the study...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-004-0495-y
更新日期:2004-09-01 00:00:00
abstract::Previous studies in mice have shown that dehydroepiandrosterone (DHEA) increases the production of Th1-associated lymphokines, and of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), by lymphocytes. However, there are no reports concerning the effect of DHEA on the production of Th2-associated lymphokines, IL-4 ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050213
更新日期:1997-06-01 00:00:00
abstract::Role of neurotrophic factors including nerve growth factor (NGF) in the mechanism of overgrowth and hypersensitivity of sensory nerve in atopic dermatitis (AD) has been proposed. Glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic factors of the nervous systems; however, the role of GDNF in ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-008-0856-z
更新日期:2008-08-01 00:00:00
abstract::Secretory component (SC) acts as a transmembrane polymeric immunoglobulin receptor of epithelial cells and is known to bind to polymeric IgA and to contribute to the secretion of secretory IgA (sIgA). We describe a new biological function for free SC (FSC) by which the expression of intercellular adhesion molecule-1 (...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00374074
更新日期:1995-01-01 00:00:00
abstract::GM-CSF is known primarily as a hematopoietic growth factor, but it has also been shown to inhibit mast cell differentiation in vitro. In order elucidate the mechanisms involved, we investigated the effects of GM-CSF in vitro on the differentiation of human leukemic mast cells (HMC-1 cells) and normal cord blood-derive...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030100225
更新日期:2001-05-01 00:00:00
abstract::Enhancement strategies are necessary to improve the dermal/transdermal bioavailability of drugs applied to the skin due to its amazing barrier, the stratum corneum. Strategies to overcome this barrier, thus improving drug release to the skin include the use of penetration enhancers, specific delivery systems, supersat...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-011-1166-4
更新日期:2011-11-01 00:00:00
abstract::Ionotrope glutamate receptors of the N-methyl-D-aspartate (NMDA) receptor type are expressed on keratinocytes and influence the intracellular calcium concentration. The importance of NMDA receptors in pathophysiological processes in the skin is, however, still unclear. Epidermal distribution patterns of NMDA receptors...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-004-0505-0
更新日期:2004-09-01 00:00:00
abstract::Little attention has been given to the involvement of sweat glands/ducts in the pathogenesis of prurigo nodularis (PN). According to recent studies, PN is likely to develop under conditions characterized by dry skin, such as atopic dermatitis (AD), suggesting a strong impact of skin dryness on PN development. No thera...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-019-01937-6
更新日期:2019-09-01 00:00:00
abstract::Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mic...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-005-0569-5
更新日期:2005-08-01 00:00:00
abstract::The deposition of immunoglobulin (Ig) at the dermo-epidermal junction (DEJ) of the skin, frequently observed in autoimmune mouse strains, is similar to that seen in patients with systemic lupus erythematosus (SLE). MRL/Mp-lpr/lpr (MRL/lpr) mice have an autosomal recessive mutant gene, lpr, which produces massive T-cel...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00370818
更新日期:1993-01-01 00:00:00
abstract::Using immunoblot and immunofluorescence analysis, we demonstrated the presence and localization of an immunoreactive form of erythrocyte ankyrin in human epidermal keratinocytes. Immunoblot analysis revealed that both human epidermis and cultured epidermal keratinocytes contained ankyrin-like proteins of molecular mas...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505038
更新日期:1996-01-01 00:00:00
abstract::The incidence of epithelioid sarcoma among patients with malignant soft tissue tumors is small, but the rates of recurrence and metastasis of this type of sarcoma are high. To date, effective chemotherapy for advanced epithelioid sarcoma has not been established and, furthermore, epithelioid sarcoma is known to exhibi...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030000127
更新日期:2000-06-01 00:00:00
abstract::Tympanic (Tty), esophageal (Tes), forehead, and hand skin temperatures, as well as the forehead evaporation rate were recorded in six men (four suffering from rosacea and two healthy controls) before, during, and after 1 h of warm bath (38 degrees-39 degrees C). During the last 30 min of the bath, the subject's face w...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00424276
更新日期:1989-01-01 00:00:00
abstract::Nephrogenic systemic fibrosis (NSF) is a disease characterized by fibrosis of the systemic organs in patients with renal failure. Following the findings of recent epidemiological studies and the finding of gadolinium (Gd) in the skin tissue of NSF patients, it is now definitely known that the use of Gd contrast agents...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-016-1689-9
更新日期:2016-12-01 00:00:00
abstract::Estrone (E1)-sulfatase and dehydroepiandrosterone (DHEA)-sulfatase activities were studied in human female epidermis. Skin specimens were obtained by abdominal or plantar biopsies. The apparent Michaelis-Menten constants for E1 and DHEA sulfatases were 35.2 microM and 8.7 microM, respectively. A substrate inhibition w...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404316
更新日期:1985-01-01 00:00:00
abstract::The roles of androgen hypersecretion, in situ enzyme activity, and androgen receptors in androgenetic alopecia in women are still a matter of debate. We studied 187 women with alopecia, which we graded I, II, or III, according to Ludwig's classification, and 21 healthy control women. All participants were subjected to...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030000184
更新日期:2000-12-01 00:00:00
abstract::Comparative measurements of collagen synthesis as a portion of total protein synthesis were performed with fragments of peripheral neurofibromas, of skin adjacent to the tumors, and of unaffected skin from patients with neurofibromatosis (NF). No significant difference was found among these various samples. Collagen s...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412930
更新日期:1986-01-01 00:00:00
abstract::The authors report 2 cases of atypical vitiligo in which they observed 1) "cockade-like" lesions resembling those of "trichrome" vitiligo (from the centre to the periphery, achromic area, hypochromic ring, normal or hyperchromic border), 2) numerous linear achromic lesions corresponding to former excoriations (Koebner...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00455391
更新日期:1978-07-28 00:00:00
abstract::Rosacea is a chronic skin disorder, characterized by persistent painful facial flushing and often accompanied by papules and pustules. To investigate the mechanism of facial flushing in rosacea, acetylcholine was administered by iontophoresis to a 10-mm diameter site in the forehead of 31 patients with rosacea and in ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-011-1177-1
更新日期:2012-03-01 00:00:00
abstract::The use of microalgae in the skin care market is already established although the scientific rationale for their benefit was not clearly defined. In this work, the biological activities of dermatologic interest of the water extract from the microalga Botryococcus braunii (BBWE) were evaluated by a battery of in vitro ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1250-4
更新日期:2012-11-01 00:00:00
abstract::Exposure to ultraviolet (UV) irradiation has detrimental effects on skin accompanied by the increased metabolism of hyaluronan (HA), a linear polysaccharide important for the normal physiological functions of skin. In this study, the modulation of human keratinocyte response to UVB irradiation by HA (970 kDa) was inve...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-011-1146-8
更新日期:2011-05-01 00:00:00
abstract::The treatment of epidermolysis bullosa acquisita (EBA) is difficult and often disappointing. We report on the successful treatment of two EBA patients with colchicine. The drug was administered orally at an initial dose of 2 mg/day. After 2 weeks of therapy a dramatic improvement was observed. Most of the cutaneous an...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00375841
更新日期:1994-01-01 00:00:00
abstract::Keratin specificity analyses of eight anti-keratin antibodies (34 beta B4 (K1), 35 beta H11 (K8), Ks 13.1 (K13), Ks 19.1 (K19), PKK1, LP34 (CK1), KL1 and AE1) using keratin protein derived from normal thigh epidermis, normal parotid gland and a human squamous cell carcinoma cell line (HSC-5) were performed, and compar...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00370816
更新日期:1993-01-01 00:00:00
abstract::Quantitative studies of the aerobic flora of seven skin sites in 16 volunteers were repeated after 3 months. The total aerobic densities of the sites differed, male carried more organisms than females and also more biotypes. Qualitative differences in the flora could be detected. ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00509062
更新日期:1982-01-01 00:00:00
abstract::Mite antigens play important roles in the pathogenesis of atopic dermatitis (AD). We recently developed a novel air cleaner (KC-850U) using charged plasma cluster ions to eliminate a variety of allergens from house environments. The present work demonstrates the ability of KC-850U to decrease the symptoms of AD induce...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-010-1095-7
更新日期:2011-07-01 00:00:00
abstract::In this study, a new procedure for the cultivation of dermal vascular endothelial cells from guinea pig ear lobe was established, and specific binding of [3H]mepyramine to the cultured cell membranes was demonstrated. The vascular endothelial cells were successfully isolated from the dermis of guinea pig ear lobes by ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00493469
更新日期:1990-01-01 00:00:00