Abstract：
:The expression and location of the Ki-67 antigen was investigated in 62 basal cell carcinomas (BCC) using immunostaining techniques (PAP and APAAP) on cryostat sections. The tumor samples were classified into three groups according to microarchitecture (nodular, superficial or fibrosing). The Ki-67 growth fraction displayed great variation between tumors belonging to the same group (nodular type, 7-67%; superficial type, 18-49%; fibrosing type 4-33%). In nodular and superficial BCC formations Ki-67 reactivity was confined either to the nuclei of three to five rows of peripheral cells, or Ki-67-positive nuclei were scattered in the central as well as in the peripheral parts of the tumor strands. The staining patterns varied in an individual tumor. Areas with a high Ki-67 labelling index often occurred adjacent to rather quiescent strands, suggesting that an individual tumor is not in a uniform state of proliferation. So far there are no experimental findings on the regulation of proliferative activity in BCCs. In view of the fact that BCCs are rather slow-growing tumors, the large Ki-67 growth fractions indicate a prolonged duration of the cell cycle or a considerable continuous loss of cells. As the microarchitecture of BCCs is much more complex than would be expected from the location of their Ki-67-positive cells, the growth pattern is probably determined to a high degree by the adjacent connective connective tissue (physical properties and texture of collagen and elastic fibres, enzyme activity of fibroblasts).
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Baum HP,Meurer I,Unteregger Gdoi
10.1007/BF00371599subject
Has Abstractpub_date
1993-01-01 00:00:00pages
291-5issue
5eissn
0340-3696issn
1432-069Xjournal_volume
285pub_type
杂志文章abstract：:Previous studies have demonstrated that permeability barrier disruption by acetone treatment significantly enhances skin permeability to both hydrophilic and amphipathic compounds, but not to highly lipophilic compounds. The purpose of the present study was to investigate the dependence of permeability on molecular we...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030100229
更新日期：2001-06-01 00:00:00
abstract：:In order to find, whether 8-MOP has an inhibiting effect on the proliferation of lymphocytes in the dark, we studied in vitro the lymphocyte proliferation by a mitogen (HgCl2) and by an antigen (tuberculin) from 16 psoriatic patients during the first oral PUVA treatment immediately before 8-MOP intake (03.--0.5 mg/kg ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00455295
更新日期：1978-05-31 00:00:00
abstract：:Skin topography and microvasculature undergo characteristic changes with age. Although several non-invasive bioengineering methods are currently available to measure them quantitatively, few publications have referred to their relationship with age in different anatomical sites. This study was carried out to observe t...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0628-y
更新日期：2006-03-01 00:00:00
abstract：:Based on reports suggesting aberrant cell-mediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear leukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from lesional and clini...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417528
更新日期：1986-01-01 00:00:00
abstract：:Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma). In this study, we analysed activities of anti-CENP-B-DNA complex in anticentromere antibody (ACA)-positive patients using DNA immunoprecipitation with purified CE...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372069
更新日期：1992-01-01 00:00:00
abstract：:It is known that eosinophils are actively involved in allergy and inflammation. The granular components of eosinophils, eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin/eosinophil protein X (EDN/EPX), play an important role in such allergic and inflammatory processes. Prurigo nodularis is a chronic ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000142
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND AND AIMS:Human VAT-1 (hVAT-1) is a homologue of the synaptic vesicle membrane protein of Torpedo californica. Its coding gene is located near the BRCA1 locus and thus hVAT-1 may be linked to an inherited predisposition to breast and ovary cancer. However, the hVAT-1 protein expression pattern in normal epith...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-003-0421-8
更新日期：2003-09-01 00:00:00
abstract：:The present study aimed to observe the therapeutic effect of combined mizolastine and proteoglycan in chronic urticaria. The patients were randomly divided into the treatment group (n = 56) and the control group (n = 44). The treatment group was medicated with calcium gluconate (10 mg/ time, 1 time/day), vitamin D3 (i...
journal_title：Archives of dermatological research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00403-019-01967-0
更新日期：2019-12-01 00:00:00
abstract：:Heparin-binding EGF-like growth factor (HB-EGF) and amphiregulin (AREG) are the members of EGF family that bind to common EGF receptor (EGFR) in the epidermis. However, the role of these two growth factors in epidermal hyperplasia of psoriasis has not been established. On the other hand, CD4+ T cells are responsible f...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-007-0809-y
更新日期：2008-01-01 00:00:00
abstract：:Angiosarcoma, a malignant tumor of vascular endothelial cell origin, is a lethal disease for which complete cure is rarely seen. The objective of this study was to determine the efficiency of photodynamic therapy (PDT) as a new treatment for angiosarcoma. PDT (630 nm, 25 J/cm2) using Photofrin for a mouse angiosarcoma...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-007-0820-3
更新日期：2008-04-01 00:00:00
abstract：:Acrolein and 4-hydroxy-2-nonenal (HNE) are both byproducts of a lipid peroxidation reaction. Actinic elastosis in photodamaged skin of aged individuals is characterized by the accumulation of fragmented elastic fibers in the sun-exposed areas. To study whether a lipid peroxidation reaction is involved in the accumulat...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030100239
更新日期：2001-07-01 00:00:00
abstract：:Oxidative stress may play a pivotal role in the pathogenesis of psoriasis, an inflammatory/hyperproliferative skin disease characterized by the cutaneous accumulation of neutrophils releasing reactive oxygen species, as revealed in a number of studies. This study was performed to demonstrate the presence of oxidative ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1624-0
更新日期：2016-04-01 00:00:00
abstract：:The mechanical properties of the in vivo dermis were measured by means of a torque applied to the skin. The resulting deformation of 2-6 degrees, including the immediate and delayed visco-elastic components, as well as the relaxation were measured, and the raw values corrected for a constant skin thickness. The experi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00406415
更新日期：1980-01-01 00:00:00
abstract：:Recently a new thin layer chromatography plate (Whatman LK 6D) became available which is extremely easy to handle and permits highly reproducible qualitative and quantitative analysis. This plate proved to be of great value for the investigation of skin surface lipids. The use of a fatty acid methyl ester as an intern...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412383
更新日期：1979-07-30 00:00:00
abstract：:Pathological alterations of capillaries, accelerated epidermopoesis, increased rate and extent of metabolism in the psoriatic lesion and first manifestation of psoriasis rarely in the first 20 years of life made us decide to investigate the human growth hormone (STH) in blood serum. In 70 patients suffering from psori...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00408223
更新日期：1981-01-01 00:00:00
abstract：:Secretory component (SC) acts as a transmembrane polymeric immunoglobulin receptor of epithelial cells and is known to bind to polymeric IgA and to contribute to the secretion of secretory IgA (sIgA). We describe a new biological function for free SC (FSC) by which the expression of intercellular adhesion molecule-1 (...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00374074
更新日期：1995-01-01 00:00:00
abstract：:The skin is the major site on anaphylaxis, and cutaneous mast cells have an important role in its reactions. The isolation and purification of rat cutaneous mast cells are described here. Rat abdominal skin was digested with collagenase and hyaluronidase, and centrifuged with Percoll. The buoyant density of cutaneous ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00426614
更新日期：1988-01-01 00:00:00
abstract：:In preparations of papillary dermis taken from clinically normal skin of patients with dermatitis herpetiformis (DH), the disappearance of granular IgA deposits induced by peptic digestion was partial at pH 4.5 and total at pH 4.1, as visualized by immunofluorescence microscopy. In a model system in which human monome...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412495
更新日期：1985-01-01 00:00:00
abstract：:The prolongation of the S-phase, characteristic of psoriatic keratinocytes, can be observed in cells of the eccrine sweat glands as well as in those of the infundibular part of hair follicles. In healthy individuals the average duration of DNA-synthesis time (ts) in the cells of the hair follicle is 6.8 h, in unaffect...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404286
更新日期：1980-01-01 00:00:00
abstract：:Serotonin is a monoamine acting as a neuromediator in the central and peripheral nervous system. Recently, serotonin has also been shown to influence T- and B-cell function. The serotonin transporter is central in the regulation of the serotonergic system and widely expressed on cells of the immune system. A functiona...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0909-3
更新日期：2009-07-01 00:00:00
abstract：:A monoclonal antibody (Ted-R-1) to the keratohyalin granules (KHGs) of the newborn rat epidermis was developed by immunizing mice with a pH 4.7 hematoxylin-stainable fraction of the extract in a 50 mM Tris-HCl buffer, pH 7.3, containing 10 micrograms/ml phenylmethylsulfonyl fluoride (PMSF) from the newborn rat whole e...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00427657
更新日期：1989-01-01 00:00:00
abstract：:In a previous study, impedance measurements and phoreographic response were shown to quantify significant differences between involved and non-involved skin in psoriasis. The same techniques were used to objectivate the evolution on skin condition on patients treated with dioxyanthranol, difluprednate, and photochemot...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00431132
更新日期：1979-03-31 00:00:00
abstract：:Vitiliginous patients undergoing photochemotherapy with TMP were less susceptible to a sun burn. To investigate this point, the MED for UV-B was measured before, 2 h, and 24 h after oral intake of TMP in 10 healthy volunteers. There was an increase of MED when UV exposure had taken place 2 h after TMP intake (P < 0.01...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403890
更新日期：1980-01-01 00:00:00
abstract：:Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown ...
journal_title：Archives of dermatological research
pub_type： 信件
doi：10.1007/s00403-004-0508-x
更新日期：2004-10-01 00:00:00
abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease associated with autoantibodies against two hemidesmosomal proteins, BP180 (type XVII collagen) and BP230. As the pathogenic relevance of antibodies against the immunodominant NC16A domain of BP180 has been clearly demonstrated, specific removal of these ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1606-7
更新日期：2016-01-01 00:00:00
abstract：:A number of studies have demonstrated an increased frequency of allergen-specific T cells producing increased amounts of interleukin-4 (IL-4) and IL-5, but little interferon-y in both the peripheral blood and skin lesions of patients with atopic dermatitis (AD). In this study, to further clarify the characteristics of...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050359
更新日期：1998-11-01 00:00:00
abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further examine this hypothesis. Blot hybridization was unable to detect 1.3 kb IL-6 transcripts in RNA extracted from no...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372034
更新日期：1992-01-01 00:00:00
abstract：:In 8 patients with idiopathic chronic urticaria suction blisters were produced simultaneously on lesional and perilesional skin in the periumbilical area without application of heat. The suction pressure was 250 mm Hg, and thus the blister production lasted from 60--120 min. The blister fluid histamine was determined ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00418572
更新日期：1979-11-01 00:00:00
abstract：:Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atheroge...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01896-y
更新日期：2019-05-01 00:00:00
abstract：:Close contacts between mast cells (MC) and nerve fibers have previously been demonstrated in normal and inflamed skin by light and electron microscopy. A key step for any study in MC-nerve interactions in situ is to simultaneously visualize both communication partners, preferably with the option of double labelling th...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050195
更新日期：1997-04-01 00:00:00
