Abstract：
:Angiosarcoma, a malignant tumor of vascular endothelial cell origin, is a lethal disease for which complete cure is rarely seen. The objective of this study was to determine the efficiency of photodynamic therapy (PDT) as a new treatment for angiosarcoma. PDT (630 nm, 25 J/cm2) using Photofrin for a mouse angiosarcoma cell line of human origin (ISOS-1) showed that the rate of cell death increased with increase in the concentration of a photosensitizer (LD50: approximately 2 microg/ml). Furthermore, PDT (630 nm, 100 J/cm2) with Photofrin (5 mg/kg, i.v.) in mice transplanted with ISOS-1 cells resulted in complete disappearance of the tumor in 40% of mice and marked inhibition of tumor growth in the remaining 60%. Significant increases in TUNEL-positive cells and Ki-67-positive cells ware seen 4 h after PDT, indicating that PDT led to not only cell death but also inhibition of the proliferation of angiosarcoma cells. The results show that PDT is effective for treatment of angiosarcoma.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Jin I,Yuji M,Yoshinori N,Makoto K,Mikio Mdoi
10.1007/s00403-007-0820-3subject
Has Abstractpub_date
2008-04-01 00:00:00pages
161-6issue
4eissn
0340-3696issn
1432-069Xjournal_volume
300pub_type
杂志文章abstract：:The aim of this study was to explore dermatologists' practices and attitudes related to educating and counseling their adolescent patients about indoor tanning. An online survey was carried out with a convenience sample of 100 dermatologists. Findings indicated that the majority of the dermatologists are actively enga...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-02026-4
更新日期：2020-11-01 00:00:00
abstract：:The hair cycling pattern differs between humans and mice: for the former it is mosaic, while the latter show a wave pattern. We focused on the presence or absence of synchronization of the hair cycle based on the distribution of Merkel cells. The three-dimensional distribution and number of Merkel cells in the skin at...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050474
更新日期：2000-04-01 00:00:00
abstract：:Conditions of oxidative stress lead to down-regulation of glutathione (GSH) and glutathione peroxidase (GPO), which could be responsible for tyrosinase induction in pigment cells. To address this question, the effects of selective modulation of GSH metabolism on melanogenic parameters of slightly and highly melanized ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050202
更新日期：1997-05-01 00:00:00
abstract：:Linoleic acid is required for the formation and maintenance of the epidermal barrier, but most of the current in vitro keratinocyte culture systems are linoleic acid-deficient. The aim of the present study was to examine the efficiency of linoleic acid uptake in human keratinocyte cultures grown under submerged and ai...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050430
更新日期：1999-07-01 00:00:00
abstract：:The dependence of epithelial spread on human serum in culture has been studied. Using measured pieces of mouse ear skin epithelial outgrowth about floating explants (epiboly) and from adherent explants was studied. Where compared directly the two systems show similar results. Because of its ease of quantitation, the a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417274
更新日期：1979-02-23 00:00:00
abstract：:Bullous pemphigoid (BP) is a chronic debilitating autoimmune blistering disease that frequently occurs in the elderly population. Previous studies have suggested a high morbidity and mortality associated with BP. However, relatively few studies have investigated prognostic factors of BP mortality, and they showed cons...
journal_title：Archives of dermatological research
pub_type： 杂志文章,meta分析
doi：10.1007/s00403-017-1736-1
更新日期：2017-07-01 00:00:00
abstract：:Topical vitamin D3 has relatively recently been introduced for the treatment of psoriasis. Synthetic vitamin D3 analogues with a high potential for inducing differentiation of cells, but with a low hypercalcemic effect have recently been developed. One such synthetic analogue of 1,25-dihydroxyvitamin D3 (calcitriol), ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050444
更新日期：1999-09-01 00:00:00
abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects the patients' quality of life greatly often from a very young age. Its worldwide incidence in children and adults varies, but it is usually among the first ten causes of dermatological consultation worldwide. There is a wide variety of treatmen...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1791-7
更新日期：2018-01-01 00:00:00
abstract：:A novel point mutation in a patient with vascular type Ehlers-Danlos syndrome is herein reported. The patient experienced pneumothorax and multiple arterial troubles during the past 10 years. The patient's hand skin was atrophic, and a paper-like atrophic scar was seen. The collagen microfibrils from the patient's ski...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0884-8
更新日期：2008-10-01 00:00:00
abstract：:IL-6/STAT3 signaling pathway has been suggested to play a role in CTCL pathogenesis. Polymorphisms in STAT3 signaling pathway-related genes might be a risk factor for CTCL. However, the exact role of inherited gene polymorphisms of IL-6 and STAT3 in the pathogenesis of CTCL is still not fully understood. The aim was t...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02062-5
更新日期：2021-01-01 00:00:00
abstract：:Close contacts between mast cells (MC) and nerve fibers have previously been demonstrated in normal and inflamed skin by light and electron microscopy. A key step for any study in MC-nerve interactions in situ is to simultaneously visualize both communication partners, preferably with the option of double labelling th...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050195
更新日期：1997-04-01 00:00:00
abstract：:Although cell death by apoptosis has been recognized as an important control mechanism in the maintenance of tissue homeostasis and in the elimination of cells with damaged DNA, information on the induction and characteristics of apoptosis in keratinocytes is rather scarce. Apoptotic mechanisms may play an important r...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505277
更新日期：1996-10-01 00:00:00
abstract：:The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:For the better part of the past century, dermatologists have regarded the skin primarily as a large protective coat. Epidermal keratinocytes were highlighted for their production of keratins and lipids, which contributed to the structural integrity and barrier formation of skin. This "saran-wrap" perspective of skin m...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/BF00638233
更新日期：1992-01-01 00:00:00
abstract：:The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved skin using standard histo...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
doi：10.1007/s00403-005-0607-3
更新日期：2005-12-01 00:00:00
abstract：:Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atheroge...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01896-y
更新日期：2019-05-01 00:00:00
abstract：:Plectin, a widespread cytoskeletal linker protein, is prominently expressed in basal keratinocytes of the epidermis. HD1, originally identified as a hemidesmosomal protein, has been suggested to be an isoform of or closely related to plectin, but the exact relationship between these proteins is unknown. Plectin has re...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050449
更新日期：1999-10-01 00:00:00
abstract：:Bradykinin has long been postulated to have a major role in physiologic human pain production. We have developed a method to systematically quantify the algogenic response to bradykinin in human skin by the direct application of bradykinin to suction blister bases. After determination of the pain threshold to bradykin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371917
更新日期：1992-01-01 00:00:00
abstract：:Langerhans cells appear to be critical for IgE-mediated allergen capture and presentation in human atopic dermatitis. The present study sought to determine whether epidermal (i.e Langerhans cells) and dermal dendritic cells in the skin of dogs with atopic dermatitis are hyperplastic and expressed surface IgE. Frozen s...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505260
更新日期：1996-09-01 00:00:00
abstract：:The case of a 44-year-old man with a primary cutaneous large B-cell non-Hodgkin's lymphoma of the scalp is reported. His mother died of gastric lymphoma and his sib brother is in a 20-year remission of T-cell lymphoma. The patient presented with a 16-year history of occipital and parietal alopecia and a recently worse...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0967-1
更新日期：2009-10-01 00:00:00
abstract：:Genetic abnormalities for different subtypes of epidermolysis bullosa (EB) have been described. In dominant simplex type EB, mutations of the K5 or K14 gene lead to disruption of basal cells and the formation of bullae. The recessive simplex types include EB with muscular dystrophy due to abnormal plectin, EB without ...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-002-0369-0
更新日期：2003-04-01 00:00:00
abstract：:Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0857-y
更新日期：2008-07-01 00:00:00
abstract：:Adhesional glycoproteins of desmosomes possess asparagine-linked, complex oligosaccharide side chains. We investigated the potential of these sugars to protect the core proteins of desmosomes and corneosomes (modified stratum corneum desmosomes) against proteolysis. Isolated pig ear epidermis was exposed sequentially ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372058
更新日期：1991-01-01 00:00:00
abstract：:Interferon-alpha combined with retinoid or PUVA is used for the treatment of cutaneous T-cell lymphoma. Anti-IFN-alpha antibodies (IFN ab) occur regularly during IFN-alpha treatment. We investigated the incidence of neutralizing and binding IFN ab and analysed their relationship with clinical and immunological paramet...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505252
更新日期：1996-08-01 00:00:00
abstract：:The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skin lesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404455
更新日期：1980-01-01 00:00:00
abstract：:We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice. Metronidazole and tinidazole ointments (1) suppressed the late-phase reaction (LPR) ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0381-4
更新日期：2003-03-01 00:00:00
abstract：:Electron microscopic aspects in ten cases of normolipidemic cutaneous xanthomatosis have been investigated. Two additional types IV and V hyperlipoproteinaemic xanthomatosis have also been included. Ultrastructural findings in all cases were similar. Abundant histiocytic cells with numerous intracytoplasmic lipid vacu...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694624
更新日期：1979-10-01 00:00:00
abstract：:Wound healing could be categorized as a chronic disorder which needs a prompt and effective medication. Nowadays, vascular problems and wound-healing progression studies relay on the role of metformin; however, the exact mechanisms for its beneficial effects are still not completely understood. The aim of the present ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01982-1
更新日期：2020-03-01 00:00:00
abstract：:Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognitio...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-017-1790-8
更新日期：2018-03-01 00:00:00
abstract：:A low molecular mass cysteine proteinase inhibitor was found and isolated from bovine hoof. Purification of the inhibitor to homogeneity was performed by carboxymethyl-papain-sepharose affinity and DE-52 ion exchange chromatographies. From 15 g of bovine hoof, 0.25 mg of cysteine proteinase inhibitor was isolated. It ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505240
更新日期：1996-07-01 00:00:00
