Abstract：
:Topical vitamin D3 has relatively recently been introduced for the treatment of psoriasis. Synthetic vitamin D3 analogues with a high potential for inducing differentiation of cells, but with a low hypercalcemic effect have recently been developed. One such synthetic analogue of 1,25-dihydroxyvitamin D3 (calcitriol), 22-oxacalcitriol (OCT), is a novel agent for the topical treatment of psoriasis. The activity of OCT in vitro was investigated and compared with that of a series of vitamin D3 analogues as to their ability to inhibit murine T lymphocyte proliferation stimulated by con-A, to suppress IL-6 and IL-8 production by keratinocytes stimulated with IL-1alpha and TNFalpha, and to inhibit AP-1- and NFkappaB-dependent reporter gene expression. OCT inhibited the proliferation of lymphocytes and suppressed IL-8 and IL-6 production by keratinocytes to the same extent as the other vitamin D3 analogues. It also inhibited AP-1- and NFkappaB-controlled luciferase activity to the same extent as the other vitamin D3 analogues, which demonstrates its mechanism of action in the suppression of inflammatory processes.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Komine M,Watabe Y,Shimaoka S,Sato F,Kake K,Nishina H,Ohtsuki M,Nakagawa H,Tamaki Kdoi
10.1007/s004030050444keywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
500-6issue
9eissn
0340-3696issn
1432-069Xpii
92910500.403journal_volume
291pub_type
杂志文章abstract：:Exposure to a dry environment leads to depletion of water from the peripheral stratum corneum layers in a process dependent on the relative humidity (RH) and the intrinsic properties of the tissue. We hypothesized that by modulating the water content of the stratum corneum in the surface layers, RH effects the rate of...
journal_title：Archives of dermatological research
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pub_type： 杂志文章,随机对照试验
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journal_title：Archives of dermatological research
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doi：10.1007/s004030050474
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050318
更新日期：1998-07-01 00:00:00
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