Abstract:
:Histamine is released from mast cells in the skin, causing urticaria and itching. However, little is known about the roles of histamine in development of eczematous lesions in contact dermatitis. Effects of histamine on development of eczematous lesions in contact dermatitis were assessed using histamine-deficient mice in which contact dermatitis was developed by repeated application of diphenylcyclopropenone. Development of eczematous lesions in contact dermatitis was suppressed in histamine-deficient mice compared to wild-type mice. H(1) agonist ((6-12-(4-imidazol)ethylamino)-N-(4-trifluoro- methylphenyl)hepatanecarboxamide) promoted development of eczematous lesions in histamine-deficient mice. H(1) receptor antagonist (loratadine) suppressed development of eczematous lesions in wild-type mice, whereas H(2) agonist (dimaprit) and receptor antagonist (cimetidine) were ineffective. These results suggest that histamine facilitates the development of eczematous lesions in a murine model of contact dermatitis via H(1) receptors.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Seike M,Takata T,Ikeda M,Kodama H,Terui T,Ohtsu Hdoi
10.1007/s00403-005-0569-5keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
68-74issue
2eissn
0340-3696issn
1432-069Xjournal_volume
297pub_type
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journal_title:Archives of dermatological research
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