Abstract：
:Forty-one male guinea pigs were treated orally with high doses of aromatic retinoid (Ro 10-9359) 25 mg/kg/day in oleum arachidis for 6 weeks. Twenty-three animals were investigated at the end of this treatment. The remaining 18 animals were investigated after an additional retinoid-free interval of 6 weeks. A control group of 13 animals received oleum arachidis only. The histological investigation of the testes of the 23 animals studied immediately after the 6-week application of retinoid revealed reduced diameters of the seminiferous tubules, disorganization and desquamation of the seminiferous epithelium with decreased spermatogenetic activity and lack of mature elements. On the other hand, the 18 animals which were investigated 6 weeks after completion of retinoid treatment did not show any alterations, as compared to the control animals. Our results show that high systemic doses of aromatic retinoid clearly induce impairment of the spermatogenesis; however, all changes were reversible within 6 weeks after withdrawal of the drug.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Tsambaos D,Hundeiker M,Mahrle G,Orfanos CEdoi
10.1007/BF00569101subject
Has Abstractpub_date
1980-01-01 00:00:00pages
153-9issue
2eissn
0340-3696issn
1432-069Xjournal_volume
267pub_type
杂志文章abstract：:Dopamine causes reflex erythema, central blanching, and piloerection depending on the dose and the type of application wheal reaction. Intracutaneous application shows from 1.5 gamma/0.1 ml wheal formation, erythema, piloerection, and blanching combined with increased heat radiation from the skin surface (AGA thermovi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412863
更新日期：1979-08-01 00:00:00
abstract：:Exposure in utero has been suggested to influence health later in life. The aim of this study was to investigate, if the use of prenatal food supplements was associated with atopic dermatitis in the offspring. Mothers who gave birth in the hospital G. B. Grassi were invited to participate in the study (n = 395). Infor...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01911-2
更新日期：2019-07-01 00:00:00
abstract：:The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) on type-IV-procollagen (basement-membrane collagen) and laminin synthesis, turnover, and secretion was studied in human A431 squamous epidermoid carcinoma cells. Type-IV procollagen and laminin were biochemically and immunologic...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00509237
更新日期：1985-01-01 00:00:00
abstract：:The rhino mouse comedolytic model and the hairless mouse photoaging model are established animal models for screening the in vivo activity of retinoids. However, the expression of the retinoic acid receptors (RARs) and cellular retinoic acid-binding proteins (CRABPs), known to regulate retinoid activity, is not comple...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00373433
更新日期：1995-01-01 00:00:00
abstract：:Classic Refsum disease (RD) is a rare, autosomal recessively-inherited disorder of peroxisome metabolism due to a defect in the initial step in the alpha oxidation of phytanic acid (PA), a C16 saturated fatty acid with four methyl side groups, which accumulates in plasma and lipid enriched tissues (please see van den ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1478-2
更新日期：2014-10-01 00:00:00
abstract：:The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) in the reconstruction of skin equivalent (SE). H&E staining showed that SE containing hyaluronic acid (HA) or HA and CCC had a thicker epidermis than the control SE. Immunohistochemical staining showed that p63 was mainly present at the b...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1283-8
更新日期：2013-01-01 00:00:00
abstract：:Vitiligo is an acquired depigmentary disorder of the skin, characterized by incomplete penetrance, multiple susceptibility loci and genetic heterogeneity. An immunologic hypothesis is currently advanced as a possible pathogenesis of vitiligo. The cytokines have an important role in pathogenesis of autoimmunity in whic...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0664-2
更新日期：2006-06-01 00:00:00
abstract：:We have examined the relationship between topical psoriasis treatment and the activity of the mixed function oxidase, aryl hydrocarbon hydroxylase (AHH), in peripheral blood monocytes and lymphocytes from 20 patients with psoriasis. These data were compared to monocyte and lymphocyte AHH activity measured in 20 normal...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00511066
更新日期：1984-01-01 00:00:00
abstract：:The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-014-1480-8
更新日期：2014-12-01 00:00:00
abstract：:Mice homozygous for three different recessive mutations known to cause pleiotropic defects in the immune system and in the skin were used to evaluate the relationship between the classical immune system and dendritic epidermal cell populations. Numbers of Langerhans cells (LCs) and Thy-1+ dendritic cells (Thy-1+DEC) w...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372621
更新日期：1990-01-01 00:00:00
abstract：:About 5% of all cutaneous squamous cell carcinomas (cSCCs) metastasize, which is the principal cause of death by this type of cancer. However, to date there are no reliable biomarkers that categorize those SCC patients that will progress to metastasis. Nuclear active IKKα diminishes Maspin levels in prostate cancer fa...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1579-6
更新日期：2015-10-01 00:00:00
abstract：:Recently, medium-dose UVA1 phototherapy (50 J/cm2) has been introduced as an effective treatment for severe atopic dermatitis (AD). In order to further elucidate the mechanisms by which medium-dose UVA1 irradiation leads to an improvement in skin status in patients with AD, biopsy specimens from ten patients before an...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030100216
更新日期：2001-04-01 00:00:00
abstract：:Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospective...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1589-4
更新日期：2015-11-01 00:00:00
abstract：:In skin inflammation, vascular endothelial growth factor (VEGF) and CXCL-8/IL-8 play an important role and are produced by activated keratinocytes. Extracts from Ginkgo biloba leaves (GBE), widely used in phytotherapy, have been reported to exert antioxidant and anti-inflammatory properties in the skin. We therefore e...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0979-x
更新日期：2010-04-01 00:00:00
abstract：:Paraneoplastic pemphigus patients (PNP) develop a group of autoantibodies, among which those against envoplakin and periplakin are almost always found. Epitope mapping has indicated that the linker subdomains of the proteins harbor the major antigenic sites recognized by PNP sera. In order to detect specific autoantib...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0901-y
更新日期：2009-10-01 00:00:00
abstract：:Bradykinin has long been postulated to have a major role in physiologic human pain production. We have developed a method to systematically quantify the algogenic response to bradykinin in human skin by the direct application of bradykinin to suction blister bases. After determination of the pain threshold to bradykin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371917
更新日期：1992-01-01 00:00:00
abstract：:The aim of the present study was to investigate the influence of three different retinoids, isotretinoin, etretinate and acitretin, on the mitogenic response of peripheral blood mononuclear cells (PBMCs) to PHA and PMA in vitro. All three retinoids at high concentrations (10(-4)M) significantly inhibited the mitogenic...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050291
更新日期：1998-04-01 00:00:00
abstract：:Recently, we discovered that New Zealand rabbits immunized with human type V collagen plus Freund's adjuvant present fibrosis and vasculitis of organs usually affected by systemic sclerosis. In this way, we studied the fibrillogenesis process to identify possible factors involved in altered remodeling observed in this...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0645-5
更新日期：2006-07-01 00:00:00
abstract：:The stimulation or inhibition of adenylate cyclase by hormones and chemicals is mediated by the stimulatory or inhibitory guanine nucleotide-binding proteins, Gs and Gi respectively. Although the presence of these G-proteins in the epidermis has been suggested, no direct information regarding their nature has been ava...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372090
更新日期：1990-01-01 00:00:00
abstract：:Mouse S91 melanoma cells which grow as a monolayer in culture were studied by transmission and scanning electron microscopy after fixation in situ. The cells were spindle-shaped and tended to grow in dense colonies. Melanosomes at all stages of melanization (stages I-IV) were observed. Other cell organelles reflected ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00431064
更新日期：1989-01-01 00:00:00
abstract：:A low molecular mass cysteine proteinase inhibitor was found and isolated from bovine hoof. Purification of the inhibitor to homogeneity was performed by carboxymethyl-papain-sepharose affinity and DE-52 ion exchange chromatographies. From 15 g of bovine hoof, 0.25 mg of cysteine proteinase inhibitor was isolated. It ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505240
更新日期：1996-07-01 00:00:00
abstract：:In order to find, whether 8-MOP has an inhibiting effect on the proliferation of lymphocytes in the dark, we studied in vitro the lymphocyte proliferation by a mitogen (HgCl2) and by an antigen (tuberculin) from 16 psoriatic patients during the first oral PUVA treatment immediately before 8-MOP intake (03.--0.5 mg/kg ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00455295
更新日期：1978-05-31 00:00:00
abstract：:The calcipotriol/betamethasone dipropionate fixed-combination gel is widely used for topical treatment of psoriasis vulgaris. It has been hypothesized that calcipotriol counteracts glucocorticoid-induced skin atrophy which is associated with changes in the extracellular matrix (ECM). To elucidate the combined effects ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1485-3
更新日期：2014-10-01 00:00:00
abstract：:Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-co...
journal_title：Archives of dermatological research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00403-006-0654-4
更新日期：2006-06-01 00:00:00
abstract：:A 2% commercial solution formulation of 5-fluorouracil (5-FU) was significantly better at delivering 5-FU than either a 1% or 5% solution. Among single component suspension formulations the highest transdermal delivery was obtained from the vehicle in which 5-FU was least soluble, isopropyl myristate (IPM), while chan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00402624
更新日期：1990-01-01 00:00:00
abstract：:To evaluate the proliferative activity of benign, borderline and malignant cutaneous melanocytic neoplasms, 30 cases of malignant melanoma (MM) and 41 cases of naevi were studied by immunostaining using a monoclonal antibody against proliferating cell nuclear antigen (PCNA). PCNA is a nuclear antigen expressed in the ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372033
更新日期：1992-01-01 00:00:00
abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1581-z
更新日期：2015-08-01 00:00:00
abstract：:Mast cell chymase is a chymotrypsin-like serine proteinase primarily stored in secretory mast cell granules. Mast cell chymase has various effects on angiotensin, metalloproteases, lipoproteins, procollagen, neuropeptides and cytokines. Recent studies have demonstrated that chymase inhibitors inhibit skin inflammation...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0542-3
更新日期：2005-04-01 00:00:00
abstract：:Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The pre...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
doi：10.1007/s00403-014-1525-z
更新日期：2015-03-01 00:00:00
abstract：:In the present study the action of various cytokines as regulators of human melanocyte growth and differentiation was examined in vitro. Primary melanocyte cultures were obtained in complete medium free of 12-O-tetradecanoylphorbol-13-acetate or serum. First passage melanocytes were treated with various concentrations...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01105076
更新日期：1995-01-01 00:00:00
