Reversal of epidermal hyperproliferation in essential fatty acid deficient guinea pigs is accompanied by rapid generation of inositol triphosphate.


:This study probes the extent of coupling between the reversal of epidermal hyperproliferation induced by essential fatty acid (EFA) deficiency in guinea pigs, the hydrolysis of epidermal phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2), and the rapid formation of inositol triphosphate (InsP3). Our data revealed that the incorporation of free [3H]-inositol into phosphatidylinositol 4P and PtdIns4,5P2 of microsomal preparations from hyperproliferative epidermis was markedly elevated when compared with epidermis from normal-fed animals. The reversal of the hyperproliferating epidermis by dietary cross-over supplementations with safflower oil and primrose oil resulted in striking morphological normalization, cellular decrease in epidermal DNA synthesis, decrease in the biosynthesis of 14C-PtdIn4,5P2 from precursor 14C-inositol, and a significant increase in the rapid generation of transient InsP3 by epidermis from the cross-over-fed animals. These findings taken together indicate that the reversal of epidermal hyperproliferation to normal in guinea pig skin and the increased capability of the tissue microsomal preparation to generate InsP3 are linked in this tissue, and raise the possibility that epidermal inositol-phospholipid metabolism may play a role in the pathogenesis of cutaneous hyperproliferative disorders.


Arch Dermatol Res


Tang W,Ziboh VA




Has Abstract


1988-01-01 00:00:00












  • Effect of RNA interference of tight junction-related molecules on intercellular barrier function in cultured human keratinocytes.

    abstract::Accumulating evidence shows that tight junctions (TJs) in the granular layer contribute to the epidermal barrier, suggesting that the regulation of TJ assembly in keratinocytes may provide a clue to understanding the role of barrier formation in epidermis. In this study, we investigated the behavior of TJ-related mole...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Yamamoto T,Saeki Y,Kurasawa M,Kuroda S,Arase S,Sasaki H

    更新日期:2008-10-01 00:00:00

  • Ki-67 antigen expression and growth pattern of basal cell carcinomas.

    abstract::The expression and location of the Ki-67 antigen was investigated in 62 basal cell carcinomas (BCC) using immunostaining techniques (PAP and APAAP) on cryostat sections. The tumor samples were classified into three groups according to microarchitecture (nodular, superficial or fibrosing). The Ki-67 growth fraction dis...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Baum HP,Meurer I,Unteregger G

    更新日期:1993-01-01 00:00:00

  • Intracellular signaling pathways involved in the release of IL-4 and VEGF from human keratinocytes by activation of kinin B1 receptor: functional relevance to angiogenesis.

    abstract::The injured skin produces a number of mediators that directly or indirectly modulate cell chemotaxis, migration, proliferation, and angiogenesis. Components of the kinin pathway including the kinin B1 receptor (B1R) have been found to occur in the human skin, but information about its role on keratinocyte biology is s...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Mejia AJ,Matus CE,Pavicic F,Concha M,Ehrenfeld P,Figueroa CD

    更新日期:2015-11-01 00:00:00

  • Three-dimensional comparative study of Merkel cell distribution in various body sites of guinea pigs and rats.

    abstract::The hair cycling pattern differs between humans and mice: for the former it is mosaic, while the latter show a wave pattern. We focused on the presence or absence of synchronization of the hair cycle based on the distribution of Merkel cells. The three-dimensional distribution and number of Merkel cells in the skin at...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tanaka T,Narisawa Y

    更新日期:2000-04-01 00:00:00

  • Histologic characteristics of lichen planus transplanted onto nude mice and cultured in vitro.

    abstract::Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice; the dense lymphocyte infiltrate in dermis disappeared, the basal...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tammi R,Hyyryläinen A,Fräki JE

    更新日期:1988-01-01 00:00:00

  • Studies of cellular mediated immunity in malignant melanoma patients by Leukocyte Adherence Inhibition Test.

    abstract::Sixteen malignant melanoma patients with different levels of tumor progression, two patients with melanoma in situ (Clark 10 two bronchogenic carcinoma patients and nine healthy controls were tested by means of the leukocyte adherence inhibition (LAI) test to assess the function of their cellular mediated immunity. Bl...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Müller S,Ernst TM

    更新日期:1980-01-01 00:00:00

  • YAP immunoreactivity is directly related to pilomatrixoma size and proliferation rate.

    abstract::Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the a...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Cappellesso R,Bellan A,Saraggi D,Salmaso R,Ventura L,Fassina A

    更新日期:2015-05-01 00:00:00

  • Expression and vitamin D-mediated regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy skin and in diabetic foot ulcers.

    abstract::Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treate...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: López-López N,González-Curiel I,Treviño-Santa Cruz MB,Rivas-Santiago B,Trujillo-Paez V,Enciso-Moreno JA,Serrano CJ

    更新日期:2014-11-01 00:00:00

  • Known HPV types have no association with keratoacanthomas.

    abstract::Certain HPV types have been linked to the genesis and development of premalignant and malignant skin diseases. There have been several contradictory reports on the role of HPV infections in the development of keratoacanthomas (KAs). To further study the involvement of HPVs in the aetiology of KAs, we investigated para...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Lu S,Syrjänen SL,Havu VK,Syrjänen S

    更新日期:1996-03-01 00:00:00

  • Histamine H1-receptor of vascular endothelial cells cultured from guinea pig skin.

    abstract::In this study, a new procedure for the cultivation of dermal vascular endothelial cells from guinea pig ear lobe was established, and specific binding of [3H]mepyramine to the cultured cell membranes was demonstrated. The vascular endothelial cells were successfully isolated from the dermis of guinea pig ear lobes by ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Noso N,Hide M,Nakamura K,Yamamoto S

    更新日期:1990-01-01 00:00:00

  • Leprosy: diagnostic and control challenges for a worldwide disease.

    abstract::Leprosy is a curable disease with well-defined etiology, but lacks better diagnostic tools, preventive and therapeutic strategies. The continued application of the Ridley-Jopling clinical classification that recognizes the natural diversity of the immune response has provided the basis for understanding leprosy, and t...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: Goulart IM,Goulart LR

    更新日期:2008-07-01 00:00:00

  • Anticentromere-protein-B--DNA complex activities in anticentromere antibody-positive patients.

    abstract::Centromere protein B (CENP-B), which is an alphoid DNA binding protein, is the target antigen in autoimmune disease patients (often those with scleroderma). In this study, we analysed activities of anti-CENP-B-DNA complex in anticentromere antibody (ACA)-positive patients using DNA immunoprecipitation with purified CE...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Muro Y,Matsumoto Y,Ohashi M

    更新日期:1992-01-01 00:00:00

  • Cell shedding from human plantar skin in vitro: evidence that two different types of protein structures are degraded by a chymotrypsin-like enzyme.

    abstract::A recently described endogenous proteolytic process in pieces of human plantar stratum corneum incubated in vitro has been further studied. This process leads to a decrease in cohesion between the cells that had been facing outwards in vivo. Using two methods, that differed with respect to efficiency, to detach surfac...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Lundström A,Egelrud T

    更新日期:1990-01-01 00:00:00

  • Inhibition of basal and ultraviolet B-induced melanogenesis by cannabinoid CB(1) receptors: a keratinocyte-dependent effect.

    abstract::Ultraviolet radiation is the major environmental insult to the skin and stimulates the synthesis of melanin in melanocytes, which then distribute it to the neighboring keratinocytes where it confers photo-protection. Skin color results from the paracrine interaction between these two cell types. Recent studies suggest...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Magina S,Esteves-Pinto C,Moura E,Serrão MP,Moura D,Petrosino S,Di Marzo V,Vieira-Coelho MA

    更新日期:2011-04-01 00:00:00

  • Anti-wrinkle and anti-whitening effects of jucá (Libidibia ferrea Mart.) extracts.

    abstract::Skin aging is a natural process of the human body that may be accelerated due to extrinsic causes. Libidibia ferrea, popularly known as jucá, is a small tree, which possesses an abundant phenolic composition with potential antioxidant and enzymatic inhibition activities. Thus, this work aimed to investigate the anti-w...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Pedrosa TD,Barros AO,Nogueira JR,Fruet AC,Rodrigues IC,Calcagno DQ,Smith MA,de Souza TP,Barros SB,de Vasconcellos MC,Silva FM,Koolen HH,Maria-Engler SS,Lima ES

    更新日期:2016-11-01 00:00:00

  • Secretory component (polymeric immunoglobulin receptor) as an intrinsic inhibitor of biological functions of interferon gamma in keratinocytes.

    abstract::Secretory component (SC) acts as a transmembrane polymeric immunoglobulin receptor of epithelial cells and is known to bind to polymeric IgA and to contribute to the secretion of secretory IgA (sIgA). We describe a new biological function for free SC (FSC) by which the expression of intercellular adhesion molecule-1 (...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Nihei Y,Maruyama K,Zhang JZ,Kobayashi K,Kaneko F

    更新日期:1995-01-01 00:00:00

  • Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model.

    abstract::Reactive oxygen species (ROS) play important roles in the process of ultraviolet-induced skin damage or photoaging. Although many enzymatic and chemical methods have been developed for evaluating ROS, evaluation methods for ROS generation in living systems are quite limited. Here we propose a unique system to visualiz...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Hakozaki T,Date A,Yoshii T,Toyokuni S,Yasui H,Sakurai H

    更新日期:2008-04-01 00:00:00

  • Relationship between covalently bound ceramides and transepidermal water loss (TEWL).

    abstract::The stratum corneum, which is the outermost layer of the skin, functions as an important barrier to maintain biological homeostasis. The multilamellar structures formed by intercellular lipids present in the stratum corneum are considered to play an important role in barrier function. Most intercellular lipids are unb...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Meguro S,Arai Y,Masukawa Y,Uie K,Tokimitsu I

    更新日期:2000-09-01 00:00:00

  • In vitro studies on microphage functions in chronic pyoderma vegetans.

    abstract::The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus a...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Djawari D,Hornstein OP

    更新日期:1978-01-01 00:00:00

  • Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients.

    abstract::Antihistamines are the first-line treatment for chronic urticaria (CU). However, some CU patients are relatively refractory to antihistamines. The mechanism underlying the interindividual variation is still unknown. The α-chain of the high-affinity IgE receptor is crucial to the IgE-mediated allergic response. The pre...

    journal_title:Archives of dermatological research

    pub_type: 临床试验,杂志文章


    authors: Guo A,Zhu W,Zhang C,Wen S,Chen X,Chen M,Zhang J,Su J,Chen W,Zhao Y,Yan S,He Y,Liu Z,Zhou H,Chen X,Li J

    更新日期:2015-03-01 00:00:00

  • Reduction of the number of immunocompetent cells in the acute stage of herpes zoster.

    abstract::Circulating and in situ mononuclear cell subsets were phenotypically characterized during both the acute and convalescent phase of herpes zoster infections in 14 patients. In peripheral blood a significant reduction in the absolute number of Leu 4+ T cells, Leu 2a+ suppressor/cytotoxic T cells, Leu 3a+ helper/inducer ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Baadsgaard O,Lindskov R,Geisler C

    更新日期:1987-01-01 00:00:00

  • Validation of Dermaphot(®) for the assessment of steroid-induced skin atrophy.

    abstract::Currently, there are no accurate and simple methods available to measure this risk of atrophy in patients treated with topical glucocorticosteroids. In the present clinical trial, we validated a new score (Dermaphot(®) score) to assess the atrophogenic potential of glucocorticosteroids. 36 healthy adult volunteers wer...

    journal_title:Archives of dermatological research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hofmann M,Salgo R,Aschoff R,Luger TA,Meurer M,Bräutigam M,Thaci D

    更新日期:2013-04-01 00:00:00

  • Effects of tumor necrosis factor-alpha on connective tissue metabolism in normal and scleroderma fibroblast cultures.

    abstract::Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and VI, fibronectin and ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Takeda K,Hatamochi A,Arakawa M,Ueki H

    更新日期:1993-01-01 00:00:00

  • Cocarcinogenic and tumor-promoting capabilities of anthralin.

    abstract::Numerous chemicals to which humans are exposed either therapeutically or as a result of living in an industrial environment constitute a potential threat as carcinogens, mutagens, and/or tumor promoters and cocarcinogens. Anthralin, and antipsoriatic agent, acts as a tumor promoter for Balb/c-3T3 mouse embryo cell cul...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Baturay NZ,Trombetta LD

    更新日期:1988-01-01 00:00:00

  • [Reversible impairment of spermatogenesis induced by aromatic retinoid in guinea pigs (author's transl)].

    abstract::Forty-one male guinea pigs were treated orally with high doses of aromatic retinoid (Ro 10-9359) 25 mg/kg/day in oleum arachidis for 6 weeks. Twenty-three animals were investigated at the end of this treatment. The remaining 18 animals were investigated after an additional retinoid-free interval of 6 weeks. A control ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Tsambaos D,Hundeiker M,Mahrle G,Orfanos CE

    更新日期:1980-01-01 00:00:00

  • Quantitative analysis of alpha 1(I) and alpha 1(III) procollagen mRNA expression in systemic sclerosis skin tissue--an in situ hybridization study.

    abstract::Human alpha 1(I) and alpha 1(III) procollagen mRNA expression in skin tissue from 15 systemic sclerosis (SSc) patients and from 7 normal control subjects was quantitatively analyzed using in situ hybridization. The grains accumulating in each area, representing procollagen mRNA expression per cell, were counted. To no...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Ohtsuka T,Koibuchi N,Sakai H,Yamakage A,Yamazaki S

    更新日期:1999-11-01 00:00:00

  • Characterization of pro-invasive mechanisms and N-terminal cleavage of ANXA1 in melanoma.

    abstract::Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Boudhraa Z,Merle C,Mazzocut D,Chezal JM,Chambon C,Miot-Noirault E,Theisen M,Bouchon B,Degoul F

    更新日期:2014-12-01 00:00:00

  • Distribution of BrdU label-retaining cells in eccrine sweat glands and comparison of the percentage of BrdU-positive cells in eccrine sweat glands and in epidermis in rats.

    abstract::Bromodeoxyuridine (BrdU) has commonly been used for detecting of label-retaining cells (LRCs). To determine if there are LRCs and the distributions of LRCs in eccrine sweat glands, 20 newborn SD rats within 24 h after birth were injected intraperitoneally with 50 mg/kg/time BrdU four consecutive times at 2-h intervals...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Chen L,Zhang M,Li H,Tang S,Fu X

    更新日期:2014-03-01 00:00:00

  • Pressure challenge test and histopathological inspections for 17 Japanese cases with clinically diagnosed delayed pressure urticaria.

    abstract::Delayed pressure urticaria (DPU) is characterized by deep dermal wheals that appear in response to a local continuous pressure. Although it has been reported to complicate as many as 40% of cases of Caucasian patients with chronic urticaria, no definitive cases of Asian/Japanese patients have been reported in English ...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章


    authors: Morioke S,Takahagi S,Iwamoto K,Shindo H,Mihara S,Kameyoshi Y,Hide M

    更新日期:2010-10-01 00:00:00

  • Strategies to reduce mortality from cutaneous malignant melanoma.

    abstract::The incidence of cutaneous malignant melanoma continues to rise. Strategies to reduce mortality in this situation include improving therapy, encouraging earlier diagnosis, and promoting prevention. New developments such as epiluminescence, sentinel node biopsy, arterial limb perfusion and the use of vaccines are discu...

    journal_title:Archives of dermatological research

    pub_type: 杂志文章,评审


    authors: MacKie RM

    更新日期:1994-01-01 00:00:00