Abstract：
:Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice; the dense lymphocyte infiltrate in dermis disappeared, the basal cell layer normalized, and the colloid bodies disappeared from epidermis, although some of them were found in dermis. The granular layer also normalized, but the stratum corneum remained hyperkeratotic 6 weeks after transplantation. In organ culture, characteristic histologic features of lichen planus disappeared in 3-5 days via a rapid necrosis of the upper part of the epidermis and formation of a new, normal-looking basal epidermis. These results suggest that lesions of lichen planus are primarily dependent on the influence of the host to maintain their typical histologic appearance.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Tammi R,Hyyryläinen A,Fräki JEdoi
10.1007/BF00412684subject
Has Abstractpub_date
1988-01-01 00:00:00pages
23-8issue
1eissn
0340-3696issn
1432-069Xjournal_volume
280pub_type
杂志文章abstract：:The glycolytic enzyme α-enolase is a plasminogen-binding protein that is generally found in the cytosolic compartment. However, α-enolase can also be expressed on cell surfaces following an inflammatory stimulus via an unknown mechanism. We investigated the effects of Streptococcus sanguinis (S. sanguinis) and the ser...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1298-1
更新日期：2013-04-01 00:00:00
abstract：:In human skin, epidermal differentiation occurs in two ways: normal differentiation, characterized by keratin 10 expression, and alternative differentiation. Alternative differentiation can be hyperproliferation-associated differentiation (expression of keratin 16) or the reinduction of an embryonic type of differenti...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/pl00007455
更新日期：2000-01-01 00:00:00
abstract：:Wound healing could be categorized as a chronic disorder which needs a prompt and effective medication. Nowadays, vascular problems and wound-healing progression studies relay on the role of metformin; however, the exact mechanisms for its beneficial effects are still not completely understood. The aim of the present ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01982-1
更新日期：2020-03-01 00:00:00
abstract：:Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1517-z
更新日期：2014-12-01 00:00:00
abstract：:Fast antigen is a cell surface protein that mediates apoptosis. Using immunohistological, flow cytometry and electron microscopic analyses, we investigated the expression of Fas antigen on various skin tissues, and on cultured SV40-transformed human epidermal keratinocyte cell line KJD and human skin squamous cell car...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371800
更新日期：1994-01-01 00:00:00
abstract：:In the study described here we investigated the possibility of an association between the aggressiveness of melanoma and multidrug resistance phenotype by analyzing the expression and activity of P-glycoprotein (Pgp) in two genetically related transplantable hamster melanomas--a melanotic (Ma) and an amelanotic (Ab) f...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000146
更新日期：2000-07-01 00:00:00
abstract：:Keloid is a complex condition with environmental and genetic risk-contributing factors. Two candidate genes, TGFβ1 and SMAD4, located in the same signaling pathway are highly expressed in the keloid fibroblast cells. In a case-control design, TGFβ1 haplotypes showed association with the risk of keloid in the present s...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1262-0
更新日期：2012-09-01 00:00:00
abstract：:An ultrastructural investigation of two cutaneous lesions in a two-year-old Turkish boy with disseminated lipogranulomatosis (Farber) revealed curvilinear bodies in fibroblasts, histiocytes, and endothelial cells; "elongated membranes" in fibroblasts and endothelial cells; "zebra bodies" in endothelial cells; and spin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694628
更新日期：1979-10-01 00:00:00
abstract：:Heparin-binding EGF-like growth factor (HB-EGF) and amphiregulin (AREG) are the members of EGF family that bind to common EGF receptor (EGFR) in the epidermis. However, the role of these two growth factors in epidermal hyperplasia of psoriasis has not been established. On the other hand, CD4+ T cells are responsible f...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-007-0809-y
更新日期：2008-01-01 00:00:00
abstract：:Human skin epithelial-like cells (NCTC strain 2544) were grown in NCTC 135 medium. Neuraminidase and hyaluronidase were added to the growth medium. Cells were incubated 96 h at 36 degrees C. Growth rate and viscosity of cell suspensions were measured after forming single cells mechanically (mopping). With addition of ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00455372
更新日期：1978-02-15 00:00:00
abstract：:The pathomorphological and pathophysiological reactions of the first skincycle of the mutant (Ng) were histologically investigated. 1. During the hair growth disturbances as the result of imperfect keratinisation changes of the morphology and function of different skin areas could be observed. 2. The developments of a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00455574
更新日期：1978-06-29 00:00:00
abstract：:The effect of the proteolytic enzyme savinase on human plantar skin in vitro was examined by light and electron microscopy to elucidate the morphological involvement of activated savinase in human epidermis. Light microscopic examination of incubated skin fragments demonstrated that the histological changes produced b...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371819
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Anogenital warts are a common human papillomavirus infection. They cause emotional distress, especially when they are in the anogenital region. Cryotherapy is a first-line treatment. Previous clinical trials and case series have reported variable results with retinoids (isotretinoin) as adjuvant therapy. OB...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02182-y
更新日期：2021-01-12 00:00:00
abstract：:Six patients with delayed pressure urticaria (DPU) applied clobetasol propionate (0.05%) ointment or its base to predetermined test sites on the right and left thigh as part of a randomized, double-blind study. A pressure challenge was administered to each test site at the initial visit and repeated after 3 days and 6...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01105080
更新日期：1995-01-01 00:00:00
abstract：:Human epidermal keratinocytes were grown in culture and the uptake of hematoporphyrin derivatives (HPDs) used in photodynamic therapy was estimated. Keratinocytes loaded with HPDs were irradiated with laser light of 632 nm generated by a helium-neon laser and cell toxicity was determined by the trypan blue exclusion t...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00510086
更新日期：1989-01-01 00:00:00
abstract：:The history of 188 caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00493466
更新日期：1990-01-01 00:00:00
abstract：:Exposure of hairless mice to the light of a germicidal lamp (254 nm) under conditions which are known to induce epidermal DNA synthesis, cell proliferation, and polyamine metabolism produced a marked increase of polyamine excretion in the urine which lasted for many days. The increase was about the same for free and a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417146
更新日期：1981-01-01 00:00:00
abstract：:For the better part of the past century, dermatologists have regarded the skin primarily as a large protective coat. Epidermal keratinocytes were highlighted for their production of keratins and lipids, which contributed to the structural integrity and barrier formation of skin. This "saran-wrap" perspective of skin m...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/BF00638233
更新日期：1992-01-01 00:00:00
abstract：:The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA-therapy) on the inflammatory infiltrate in 14 psoriatic skin lesions and on normal skin of 7 controls were investigated by means of autoradiography and planimetry. Under PUVA-therapy, one finds a significant decrease in dermal cells per millimeter lesion in...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404455
更新日期：1980-01-01 00:00:00
abstract：:In a group of 40 patients suffering from wide-spread psoriasis oral administration of a retinoid (Ro 10-9359) was followed by PUVA therapy. The clearance rate was increased by 30% as compared to PUVA alone. Except for cheilitis no side effects were seen. Histological analysis in 20 patients before, during and after th...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412661
更新日期：1979-05-04 00:00:00
abstract：:The safety and efficacy of imiquimod 5% cream is being evaluated for the treatment of dysplastic lesions of the epidermis (actinic keratoses, AK). The objective of this clinical study was to describe the pharmacokinetics and safety of topical imiquimod during multiple dosing of AK subjects. A total of 58 adult subject...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/s00403-004-0465-4
更新日期：2004-06-01 00:00:00
abstract：:The stimulation or inhibition of adenylate cyclase by hormones and chemicals is mediated by the stimulatory or inhibitory guanine nucleotide-binding proteins, Gs and Gi respectively. Although the presence of these G-proteins in the epidermis has been suggested, no direct information regarding their nature has been ava...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372090
更新日期：1990-01-01 00:00:00
abstract：:The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus a...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
更新日期：1978-09-28 00:00:00
abstract：:Reactive oxygen species (ROS) play important roles in the process of ultraviolet-induced skin damage or photoaging. Although many enzymatic and chemical methods have been developed for evaluating ROS, evaluation methods for ROS generation in living systems are quite limited. Here we propose a unique system to visualiz...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-007-0804-3
更新日期：2008-04-01 00:00:00
abstract：:The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00418573
更新日期：1979-11-01 00:00:00
abstract：:The goal of this study is to investigate commercially available cosmetics (foundations, skin care creams) which also claim to include a sun protection factor (SPF). Are these products, which are not considered sunscreen products, helpful or could they be harmful? Using an in vitro method, we tested the effectiveness o...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-0974-2
更新日期：2009-09-01 00:00:00
abstract：:Conditions of oxidative stress lead to down-regulation of glutathione (GSH) and glutathione peroxidase (GPO), which could be responsible for tyrosinase induction in pigment cells. To address this question, the effects of selective modulation of GSH metabolism on melanogenic parameters of slightly and highly melanized ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050202
更新日期：1997-05-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) mutations have recently been proposed as important contributors to ageing and degenerative diseases. In this study, we applied the polymerase chain reaction technique to detect 4.977 bp-deleted mtDNA, the most common and abundant deletion of mtDNA, in normal human skin. None of the skin speci...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371798
更新日期：1994-01-01 00:00:00
abstract：:The demonstration of cytokine mRNA expression in epidermal cells by the polymerase chain reaction technique preceded by reverse transcription (RT-PCR) requires linear test conditions (i.e. that the product obtained after amplification reflects the relative amounts of starting material) and high reproducibility, specif...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00370722
更新日期：1994-01-01 00:00:00
abstract：:The expression of IL-8 in psoriasis has been clearly shown with the use of immunocytochemical, RT-PCR and in situ hybridization methods. The presence of its ligand, the IL-8 receptor, has been demonstrated by the RT-PCR technique. We report here a study of the expression of both IL-8 type A and B receptors by immunohi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050218
更新日期：1997-07-01 00:00:00
