Abstract:
:The history of 188 caucasian patients with atopic dermatitis (AD) and of 2,151 family members has been analyzed. Of the AD patients 48% suffered from respiratory atopy (36% rhinitis, 28% asthma, and 15% both). AD showed by far the earliest onset of all atopic diseases: 50% of our patients had skin lesions before the age of 2 years and 60% before the age of 5 years. In contrast, symptoms of allergic asthma developed in 40% of AD patients before the age of 5 years in comparison with only 25% who had allergic rhinitis. AD affects females more frequently than males (male to female ratio 1:1.5), regardless of whether additional respiratory atopies are present or not. In contrast, respiratory atopies develop more frequently in males than in females (male to female ratio 1.5:1). Mothers with respiratory atopy more often have atopic children (26%) than do fathers with respiratory atopy (13%). Finally, risk figures for genetic counselling are given. In short, the general risk of developing AD (3%) and atopy (7%) increases by a factor of two with each first-degree family member already suffering from atopy.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Küster W,Petersen M,Christophers E,Goos M,Sterry Wdoi
10.1007/BF00493466subject
Has Abstractpub_date
1990-01-01 00:00:00pages
98-102issue
2eissn
0340-3696issn
1432-069Xjournal_volume
282pub_type
杂志文章abstract::Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases characterized by a loss of cell-cell adhesion and by autoantibodies directed against epidermal cadherins. PF antigen has been established as desmoglein I which is located strictly on the desmosome, whereas the precise ultrastructur...
journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00403890
更新日期:1980-01-01 00:00:00
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journal_title:Archives of dermatological research
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更新日期:2010-11-01 00:00:00
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更新日期:1982-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:1979-02-23 00:00:00
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pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00402624
更新日期:1990-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00373433
更新日期:1995-01-01 00:00:00
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journal_title:Archives of dermatological research
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journal_title:Archives of dermatological research
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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