Abstract:
:Sphingosylphosphorylcholine (SPC) has been reported to stimulate wound healing by its potent mitogenic effect. Fibronectin (FN) is a cell-adhesion protein that plays an important role in cell migration and collagen deposition during wound healing. In order to elucidate further the mechanism involved in the accelerated wound healing stimulated by SPC, we studied the role of SPC in FN production in cultured human dermal fibroblasts. We demonstrated that SPC dose- and time-dependently enhanced the expression of FN in human dermal fibroblast at the protein and mRNA levels. IL-6 is known to stimulate the production of FN in fibroblasts. SPC also markedly induced IL-6 production in cultured human dermal fibroblasts in a dose- and time-dependent manner. We also demonstrated that FN mRNA expression in human dermal fibroblasts was upregulated 4 h after IL-6 treatment. Moreover, pretreatment with neutralizing anti-IL-6 antibodies partially blocked the upregulation of FN mRNA expression induced by SPC in human dermal fibroblasts. These results indicate that SPC may stimulate FN synthesis through IL-6 production in cultured human dermal fibroblasts.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Suhr KB,Tsuboi R,Seo EY,Piao YJ,Lee JH,Park JK,Ogawa Hdoi
10.1007/s00403-002-0357-4keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
433-7issue
10-11eissn
0340-3696issn
1432-069Xjournal_volume
294pub_type
杂志文章abstract::Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...
journal_title:Archives of dermatological research
pub_type: 杂志文章,评审
doi:10.1007/s00403-008-0889-3
更新日期:2009-01-01 00:00:00
abstract::Dimethylfumarate (DMF), the essential ingredient of the drug product Fumaderm®, is used to treat psoriasis with a recognized favorable long-term safety profile. Interestingly, the mode of action and the pharmacokinetics of DMF in psoriasis or multiple sclerosis are not fully explored. It is known that DMF as an α,β-un...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-013-1332-y
更新日期:2013-07-01 00:00:00
abstract::Programmed cell death protein-1 (PD-1) is primarily recognized as an inhibitory receptor involved in the regulation of immunological tolerance. However, recent studies have indicated that PD-1/PD-L1 signaling could also regulate the functions of nonimmune cells and may be involved in regulating hair biology. In this s...
journal_title:Archives of dermatological research
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doi:10.1007/s00403-020-02169-9
更新日期:2021-01-05 00:00:00
abstract::The safety and efficacy of imiquimod 5% cream is being evaluated for the treatment of dysplastic lesions of the epidermis (actinic keratoses, AK). The objective of this clinical study was to describe the pharmacokinetics and safety of topical imiquimod during multiple dosing of AK subjects. A total of 58 adult subject...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s00403-004-0465-4
更新日期:2004-06-01 00:00:00
abstract::Annexin A1 deregulation is often associated with cancer. Indeed we have shown that annexin A1 is overexpressed in melanoma and promotes metastases by formyl peptide receptor stimulation and MMP2 expression. Here, we demonstrated in different melanoma cell lines that annexin A1-MMP2 induction is mediated by MAPK and ST...
journal_title:Archives of dermatological research
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doi:10.1007/s00403-014-1517-z
更新日期:2014-12-01 00:00:00
abstract::Recent evidence indicates that the biologically active metabolite of vitamin D3, 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3], has an effect on the regulation of the immune response. We investigated whether topical treatment of mice with 1 alpha,25(OH)2D3 influences the contact hypersensitivity (CHS) response to...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00412982
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abstract::A recently described endogenous proteolytic process in pieces of human plantar stratum corneum incubated in vitro has been further studied. This process leads to a decrease in cohesion between the cells that had been facing outwards in vivo. Using two methods, that differed with respect to efficiency, to detach surfac...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00371642
更新日期:1990-01-01 00:00:00
abstract::Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases characterized by a loss of cell-cell adhesion and by autoantibodies directed against epidermal cadherins. PF antigen has been established as desmoglein I which is located strictly on the desmosome, whereas the precise ultrastructur...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02507101
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-012-1262-0
更新日期:2012-09-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00370816
更新日期:1993-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00404316
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pub_type: 杂志文章
doi:10.1007/s00403-015-1582-y
更新日期:2015-10-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF01105793
更新日期:1995-01-01 00:00:00
abstract::The authors report 2 cases of atypical vitiligo in which they observed 1) "cockade-like" lesions resembling those of "trichrome" vitiligo (from the centre to the periphery, achromic area, hypochromic ring, normal or hyperchromic border), 2) numerous linear achromic lesions corresponding to former excoriations (Koebner...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00455391
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372090
更新日期:1990-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050398
更新日期:1999-04-01 00:00:00
abstract::The cellular DNA ploidy of 30 cases of malignant melanoma was measured by 4',6-diamidino-2-phenylindole-DNA (DAPI-DNA) microfluorometry. DNA histograms and DNA index values were compared among melanomas of different cell morphology. Epithelioid cell melanomas often showed greater DNA aneuploidy than spindle cell melan...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00372134
更新日期:1993-01-01 00:00:00
abstract::Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-co...
journal_title:Archives of dermatological research
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00403-006-0654-4
更新日期:2006-06-01 00:00:00
abstract::The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved skin using standard histo...
journal_title:Archives of dermatological research
pub_type: 临床试验,杂志文章
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abstract::One of the primary events in the pathogenesis of acne vulgaris is abnormal follicular keratinization. Since oral isotretinoin therapy reduces follicular hyperkeratinization in acne, our study has been designed to determine whether epidermal lipid composition of the epithelium of sebaceous follicles is affected by isot...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00417712
更新日期:1988-01-01 00:00:00
abstract::The treatment of epidermolysis bullosa acquisita (EBA) is difficult and often disappointing. We report on the successful treatment of two EBA patients with colchicine. The drug was administered orally at an initial dose of 2 mg/day. After 2 weeks of therapy a dramatic improvement was observed. Most of the cutaneous an...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00375841
更新日期:1994-01-01 00:00:00
abstract::To investigate the relationship between smoking and primary basal cell carcinoma (BCC), we analyzed data from a 16 year prospective study among randomly selected adults in Nambour, Queensland, Australia. Participants underwent a skin examination in 1992 and took part in an intervention study and follow-up. Information...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-014-1503-5
更新日期:2014-11-01 00:00:00
abstract::Because of its easy accessibility, the skin is a very attractive target for gene therapy purposes. To study potential clinical applications in a preclinical setting, appropriate animal models are needed. Pig skin is very similar to human skin, and a variety of human diseases that are potentially amenable to gene thera...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-006-0653-5
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00417528
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00585924
更新日期:1987-01-01 00:00:00
abstract::We report the clinical features of 62 consecutive patients with lichen planus observed in 18 months. The largest number of cases occurred between 50 and 70 years of age. Thirty-four patients had lichen planus only. In the remainder, lichen planus was associated with chronic liver diseases (16 cases), immune-related di...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF00376614
更新日期:1991-01-01 00:00:00
abstract::Stratum corneum forms the UV barrier. The effect of ultraviolet B (UVB) on normal skin was extensively studied; however, its effect on barrier perturbed skin remains undefined. Both barrier perturbation and UVB irradiation induce endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in keratinocytes. M...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s00403-017-1753-0
更新日期:2017-09-01 00:00:00
abstract::Investigations on the nutrient requirements of Malassezia yeasts led to the preparation of a new minimal medium consisting of an amino nitrogen and a lipid source, which only allowed the growth of the species M. furfur. Carbohydrates, electrolytes, vitamins and trace elements were not required. Using the basal medium,...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/s004030050304
更新日期:1998-05-01 00:00:00
abstract::Interleukin-6-like (IL-6-like) immunoreactivity was sought in inflamed and normal human skin using the same immunohistochemical technique as for detection of neuropeptides. Such immunoreactivity was found in dermal and in a few intraepidermal nerve-like fibres in biopsy specimens from inflamed skin from patients with ...
journal_title:Archives of dermatological research
pub_type: 杂志文章
doi:10.1007/BF02505230
更新日期:1996-07-01 00:00:00