当前位置： SCI文献检索 > ARCHIVES OF DERMATOLOGICAL RESEARCH期刊下所有文献 > Immunohistochemical localization of interleukin-6-like immunoreactivity to peripheral nerve-like structures in normal and inflamed human skin.

Immunohistochemical localization of interleukin-6-like immunoreactivity to peripheral nerve-like structures in normal and inflamed human skin.

Abstract：

:Interleukin-6-like (IL-6-like) immunoreactivity was sought in inflamed and normal human skin using the same immunohistochemical technique as for detection of neuropeptides. Such immunoreactivity was found in dermal and in a few intraepidermal nerve-like fibres in biopsy specimens from inflamed skin from patients with positive epicutaneous patch-test reactions to nickel sulphate, and in skin specimens from patients with atopic dermatitis and prurigo nodularis. However, IL-6-like immunoreactivity was also found in nerve-like fibres in specimens from nonlesional skin. In skin from patients with positive epicutaneous patch-test reactions there was a statistically significantly (P < 0.01) higher number of IL-6-positive nerve fibres in the epidermis than in normal skin, in contrast to the papillary dermis, in which no difference was found. Moreover, there were clusters of nerve-like fibres with IL-6-like immunoreactivity in the dermis of prurigo nodularis lesions. In these nerve-like fibres, the colocalization of the immunoreactivities for IL-6 and calcitonin gene-related peptide was indicated. Localization of immunoreactivity to nerve-like structures surrounding the eccrine sweat glands indicates that IL-6 is present in autonomic as well as in sensory nerve fibres.

journal_name

Arch Dermatol Res

journal_title

Archives of dermatological research

authors

Nordlind K,Chin LB,Ahmed AA,Brakenhoff J,Theodorsson E,Lidén S

doi

10.1007/BF02505230

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

431-5

issue

8

eissn

0340-3696

issn

1432-069X

journal_volume

288

pub_type

杂志文章

相关文献

ARCHIVES OF DERMATOLOGICAL RESEARCH文献大全
  • A novel approach in psoriasis: first usage of known protein oxidation markers to prove oxidative stress.

    abstract：:Oxidative stress may play a pivotal role in the pathogenesis of psoriasis, an inflammatory/hyperproliferative skin disease characterized by the cutaneous accumulation of neutrophils releasing reactive oxygen species, as revealed in a number of studies. This study was performed to demonstrate the presence of oxidative ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-016-1624-0

    authors： Yazici C,Köse K,Utaş S,Tanrikulu E,Taşlidere N

    更新日期：2016-04-01 00:00:00

  • Immunohistochemical detection of lipid peroxidation products, protein-bound acrolein and 4-hydroxynonenal protein adducts, in actinic elastosis of photodamaged skin.

    abstract：:Acrolein and 4-hydroxy-2-nonenal (HNE) are both byproducts of a lipid peroxidation reaction. Actinic elastosis in photodamaged skin of aged individuals is characterized by the accumulation of fragmented elastic fibers in the sun-exposed areas. To study whether a lipid peroxidation reaction is involved in the accumulat...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s004030100239

    authors： Tanaka N,Tajima S,Ishibashi A,Uchida K,Shigematsu T

    更新日期：2001-07-01 00:00:00

  • Effects of different doses of abobotulinumtoxinA for the treatment of anterior gingival smile.

    abstract：:Botulinum toxin type A (BoNT-A) is an easy and fast treatment for gingival smile (GS). The objective of the study was to compare the reduction of gingival exposure using three different doses of abobotulinumtoxinA (ABO) in patients with different severities of anterior GS, and to assess treatment safety and patients' ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-020-02096-9

    authors： Hexsel D,Dal'Forno T,Camozzato F,Valente I,Soirefmann M,Silva AF,Siega C

    更新日期：2020-07-28 00:00:00

  • Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease.

    abstract：:The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR com...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章,评审

    doi：10.1007/s00403-014-1480-8

    authors： Leo MS,Sivamani RK

    更新日期：2014-12-01 00:00:00

  • iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis.

    abstract：:The study aimed at detecting differentially expressed proteins in the stratum corneum of dandruff versus non-dandruff scalps to better understand dandruff aetiology. iTRAQ-based quantitative proteomic analysis revealed a total of 68 differentially expressed biomarkers. A detailed analysis of their known physiological ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-016-1681-4

    authors： Cavusoglu N,Delattre C,Donovan M,Bourassa S,Droit A,El Rawadi C,Jourdain R,Bernard D

    更新日期：2016-11-01 00:00:00

  • Isolation and amino acid sequence of a cystatin-type cysteine proteinase inhibitor from bovine hoof.

    abstract：:A low molecular mass cysteine proteinase inhibitor was found and isolated from bovine hoof. Purification of the inhibitor to homogeneity was performed by carboxymethyl-papain-sepharose affinity and DE-52 ion exchange chromatographies. From 15 g of bovine hoof, 0.25 mg of cysteine proteinase inhibitor was isolated. It ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/BF02505240

    authors： Tsushima H,Higashiyama K,Mine H

    更新日期：1996-07-01 00:00:00

  • Biological activities of dermatological interest by the water extract of the microalga Botryococcus braunii.

    abstract：:The use of microalgae in the skin care market is already established although the scientific rationale for their benefit was not clearly defined. In this work, the biological activities of dermatologic interest of the water extract from the microalga Botryococcus braunii (BBWE) were evaluated by a battery of in vitro ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-012-1250-4

    authors： Buono S,Langellotti AL,Martello A,Bimonte M,Tito A,Carola A,Apone F,Colucci G,Fogliano V

    更新日期：2012-11-01 00:00:00

  • Why is polymorphous light eruption so common in young women?

    abstract：:Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown ...

    journal_title：Archives of dermatological research

    pub_type： 信件

    doi：10.1007/s00403-004-0508-x

    authors： Aubin F

    更新日期：2004-10-01 00:00:00

  • Receptor-linked adenylate cyclase in the membranes of cultured human epidermal keratinocytes.

    abstract：:The beta-adrenergic receptors, previously shown to be present on the membranes of cultured human epidermal keratinocytes, were found to be functionally coupled to membrane-bound adenylate cyclase. Using membrane preparations, the enzyme could be activated by guanosine triphosphate (GTP), the stable GTP analog GPP(HN)p...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/BF00407740

    authors： Cavey MT,Cavey D,Shroot B,Reichert U,Gazith J

    更新日期：1986-01-01 00:00:00

  • Understanding the phenotypic similarities between IFAP and Olmsted syndrome from a molecular perspective: the interaction of MBTPS2 and TRPV3.

    abstract：:Ichthyosis Follicularis, Atrichia, and Photophobia (IFAP) is a severe rare genetic disorder caused by mutations in the gene encoding the Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2). Olmsted syndrome is another rare genetic disease with overlapping clinical features caused by mutations in the gene en...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-017-1762-z

    authors： Nemer G,Safi R,Kreidieh F,Usta J,Bergqvist C,Ballout F,Btadini W,Hamzeh N,Abbas O,Kibbi AG,Shimomura Y,Kurban M

    更新日期：2017-10-01 00:00:00

  • Estimated serum vitamin D status, vitamin D intake, and risk of incident alopecia areata among US women.

    abstract：:Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the associat...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-016-1687-y

    authors： Thompson JM,Li T,Park MK,Qureshi AA,Cho E

    更新日期：2016-11-01 00:00:00

  • Antibodies against extractable components from Propionibacterium acnes in humans with and without acne vulgaris.

    abstract：:Acidic polysaccharides (AP) are released from Propionibacterium acnes I and II during growth. Similar antigens are released from two strains of P. avidum, but in a smaller amount. Furthermore, prostaglandin-like substances (PLS) have been isolated from the lipid fraction of P. acnes. The AP antigens give rise to a pre...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/BF00406418

    authors： Dalen A,Hellgren L,Iversen OJ,Vincent J

    更新日期：1980-01-01 00:00:00

  • The polymorphisms of IL-6/STAT3 signaling pathway may contribute to cutaneous T-cell lymphomas susceptibility.

    abstract：:IL-6/STAT3 signaling pathway has been suggested to play a role in CTCL pathogenesis. Polymorphisms in STAT3 signaling pathway-related genes might be a risk factor for CTCL. However, the exact role of inherited gene polymorphisms of IL-6 and STAT3 in the pathogenesis of CTCL is still not fully understood. The aim was t...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-020-02062-5

    authors： Olszewska B,Gleń J,Zabłotna M,Nowicki RJ,Sokołowska-Wojdyło M

    更新日期：2021-01-01 00:00:00

  • Ultrastructure of skin from Refsum disease with emphasis on epidermal lamellar bodies and stratum corneum barrier lipid organization.

    abstract：:Classic Refsum disease (RD) is a rare, autosomal recessively-inherited disorder of peroxisome metabolism due to a defect in the initial step in the alpha oxidation of phytanic acid (PA), a C16 saturated fatty acid with four methyl side groups, which accumulates in plasma and lipid enriched tissues (please see van den ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-014-1478-2

    authors： Menon GK,Orsó E,Aslanidis C,Crumrine D,Schmitz G,Elias PM

    更新日期：2014-10-01 00:00:00

  • Interleukin-33: increasing role in dermatological conditions.

    abstract：:Interleukin-33 is a novel and an unconventional member of IL-1 family. It is an inflammation-induced factor with dual function exercising its role as an intracellular regulator of gene expression, as well as, an extracellular alarm mediator. It is a ligand for ST2, a heterodimeric membrane-bound receptor of the orphan...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章,评审

    doi：10.1007/s00403-016-1638-7

    authors： Balato A,Raimondo A,Balato N,Ayala F,Lembo S

    更新日期：2016-07-01 00:00:00

  • Glucocorticoids inhibit proliferation and adhesion of the IL-3-dependent mast cell line, MC/9, to NIH/3T3 fibroblasts, with an accompanying decrease in IL-3 receptor expression.

    abstract：:We investigated the effects of glucocorticoids on IL-3-dependent proliferation and c-kit expression of cells of the mouse mast cell line, MC/9. Glucocorticoids (dexamethasone, prednisolone, and hydrocortisone) inhibited IL-3-dependent MC/9 cell proliferation, whereas sex steroids (progesterone, beta-estradiol, and tes...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s004030050398

    authors： Sakai H,Toyota N,Ito F,Takahashi H,Hashimoto Y,Iizuka H

    更新日期：1999-04-01 00:00:00

  • Circulating levels of adiponectin, leptin, resistin and visfatin in non-diabetics patients with hidradenitis suppurativa.

    abstract：:Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with insulin resistance (IR), metabolic syndrome and increased cardiovascular risk. Adipokines are biologically active, pleotropic molecules which have been involved in the development of IR and in the pathogenesis of several chronic inflammato...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-019-02018-4

    authors： González-López MA,Vilanova I,Ocejo-Viñals G,Arlegui R,Navarro I,Guiral S,Mata C,Pérez-Paredes MG,Portilla V,Corrales A,González-Vela MC,González-Gay MA,Blanco R,Hernández JL

    更新日期：2020-10-01 00:00:00

  • Induction and repair of UVB-induced cyclobutane pyrimidine dimers and (6-4) photoproducts in organ-cultured normal human skin.

    abstract：:To examine the induction and repair of UV-induced DNA damage, indirect immunofluorescence was performed on UVB-irradiated organ-cultured normal human skin using monoclonal antibodies specific for either cyclobutane pyrimidine dimers or (6-4) photoproducts. Nuclear immunofluorescence of cyclobutane pyrimidine dimers an...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/BF00375800

    authors： Muramatsu T,Kobayashi N,Tada H,Yamaji M,Shirai T,Mori T,Ohnishi T

    更新日期：1992-01-01 00:00:00

  • Immunohistochemical study of Toll-like receptors 1 and 2 expression in cutaneous lichen planus lesions.

    abstract：:Lichen planus (LP) is a chronic inflammatory, T cell-mediated autoimmune skin disease. Innate immunity could explain the interplay between environmental triggers and the autoimmune cascade leading to disease development. Toll-like receptors (TLRs) are important components of the innate immune system, with no previous ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-012-1267-8

    authors： Salem SA,Abu-Zeid RM,Nada OH

    更新日期：2013-03-01 00:00:00

  • Eosinophil cationic protein- and eosinophil-derived neurotoxin/eosinophil protein X-immunoreactive eosinophils in prurigo nodularis.

    abstract：:It is known that eosinophils are actively involved in allergy and inflammation. The granular components of eosinophils, eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin/eosinophil protein X (EDN/EPX), play an important role in such allergic and inflammatory processes. Prurigo nodularis is a chronic ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s004030000142

    authors： Johansson O,Liang Y,Marcusson JA,Reimert CM

    更新日期：2000-08-01 00:00:00

  • Gene expression of retinoic acid receptors and cellular retinoic acid-binding proteins in rhino and hairless mouse skin.

    abstract：:The rhino mouse comedolytic model and the hairless mouse photoaging model are established animal models for screening the in vivo activity of retinoids. However, the expression of the retinoic acid receptors (RARs) and cellular retinoic acid-binding proteins (CRABPs), known to regulate retinoid activity, is not comple...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/BF00373433

    authors： Beehler BC,Chen S,Tramposch KM

    更新日期：1995-01-01 00:00:00

  • Treatment of polymorphous light eruption.

    abstract：:This study was designed in order to prove on a large-scale basis the efficacy of oral photochemotherapy (PUVA) in the prevention of polymorphous light eruption (PLE), to work out indication criteria for PUVA treatment of this disease, and to establish a simple method based on anamnestic data to differentiate UVA from ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/BF00417337

    authors： Gschnait F,Schwarz T,Ladich I

    更新日期：1983-01-01 00:00:00

  • Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model.

    abstract：:Reactive oxygen species (ROS) play important roles in the process of ultraviolet-induced skin damage or photoaging. Although many enzymatic and chemical methods have been developed for evaluating ROS, evaluation methods for ROS generation in living systems are quite limited. Here we propose a unique system to visualiz...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-007-0804-3

    authors： Hakozaki T,Date A,Yoshii T,Toyokuni S,Yasui H,Sakurai H

    更新日期：2008-04-01 00:00:00

  • Pharmacokinetics and safety of imiquimod 5% cream in the treatment of actinic keratoses of the face, scalp, or hands and arms.

    abstract：:The safety and efficacy of imiquimod 5% cream is being evaluated for the treatment of dysplastic lesions of the epidermis (actinic keratoses, AK). The objective of this clinical study was to describe the pharmacokinetics and safety of topical imiquimod during multiple dosing of AK subjects. A total of 58 adult subject...

    journal_title：Archives of dermatological research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00403-004-0465-4

    authors： Harrison LI,Skinner SL,Marbury TC,Owens ML,Kurup S,McKane S,Greene RJ

    更新日期：2004-06-01 00:00:00

  • Coexpression of keratins 13 and 16 in human keratinocytes indicates association between hyperproliferation-associated and retinoid-induced differentiation.

    abstract：:In human skin, epidermal differentiation occurs in two ways: normal differentiation, characterized by keratin 10 expression, and alternative differentiation. Alternative differentiation can be hyperproliferation-associated differentiation (expression of keratin 16) or the reinduction of an embryonic type of differenti...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/pl00007455

    authors： van Rossum MM,Mommers JM,van de Kerkhof PC,van Erp PE

    更新日期：2000-01-01 00:00:00

  • Phenotypic profiling of keloid scars using FT-IR microspectroscopy reveals a unique spectral signature.

    abstract：:Keloid disease (KD) is a quasineoplastic fibroproliferative tumour of unknown origin causing a progressive, recurrent dermal lesion. KD is not homogeneous in nature and shows phenotypic structural differences between its distinct peripheral margins compared to its centre. The keloid margin is often symptomatically mor...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-010-1071-2

    authors： Hollywood KA,Maatje M,Shadi IT,Henderson A,McGrouther DA,Goodacre R,Bayat A

    更新日期：2010-12-01 00:00:00

  • The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation.

    abstract：:CCN2 plays an important role in the pathogenesis of hypertrophic scars (HTSs). Although CCN2 is involved in many fibroproliferative events, the CCN2 induction signaling pathway in HTSs is yet to be elucidated. Here, we first investigated the effect of the mitogen-activated protein kinases (MAPKs) on CCN2-induced α-smo...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-013-1334-9

    authors： Hu X,Wang H,Liu J,Fang X,Tao K,Wang Y,Li N,Shi J,Wang Y,Ji P,Cai W,Bai X,Zhu X,Han J,Hu D

    更新日期：2013-07-01 00:00:00

  • Transient immune deposits in the papillary dermis and in the epidermis. A light-microscopical study on the experimental Arthus reaction.

    abstract：:To have as further insight into the localizations of immune deposits in the skin the reversed passive and the passive Arthus reactions were carried out in the foot-pads skin of guinea-pigs using horseradish peroxidase as antigen. The transient localizations of immune deposits in the papillary dermis and in the epiderm...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/BF00404457

    authors： Ueki H,Nakaye M,Masuda T

    更新日期：1980-01-01 00:00:00

  • The quantitative distribution of percutaneously applied caffeine in the human skin.

    abstract：:The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/BF00418573

    authors： Zesch A,Schaefer H,Stüttgen G

    更新日期：1979-11-01 00:00:00

  • Palmitate induces COX-2 expression via the sphingolipid pathway-mediated activation of NF-κB, p38, and ERK in human dermal fibroblasts.

    abstract：:It has been suggested that free fatty acids (FFA) such as palmitate, which are secreted from enlarged adipocytes in the subcutaneous fat of obese subjects, serve as a link between obesity and altered skin functions. Cyclooxygenease-2 (COX-2) and prostanoids participate in the induction of impaired dermal function. In ...

    journal_title：Archives of dermatological research

    pub_type： 杂志文章

    doi：10.1007/s00403-013-1434-6

    authors： Oh E,Yun M,Kim SK,Seo G,Bae JS,Joo K,Chae GT,Lee SB

    更新日期：2014-05-01 00:00:00