Abstract：
:Lichen planus (LP) is a chronic inflammatory, T cell-mediated autoimmune skin disease. Innate immunity could explain the interplay between environmental triggers and the autoimmune cascade leading to disease development. Toll-like receptors (TLRs) are important components of the innate immune system, with no previous evaluation of TLRs 1 and 2 in cutaneous LP. This work aims to investigate TLRs 1 and 2 expression in cutaneous LP. This case-control study included 30 patients with LP and 15 healthy controls. Biopsies from the patients' lesional skin and from the controls' normal skin were examined immunohistochemically for TLR 1 and 2 expression. A significant re-localization was found in TLR1 expression with a higher percentage of basal and a significantly lower percentage of homogenous epidermal expression in patients (73.3 and 0 %, respectively) compared with controls (13.3 and 73.3 %, respectively) (P < 0.001). TLR2 showed a significantly higher percentage of epidermal expression (more in the upper spinous layer) and significantly lower percentage of epidermal but more basal expression in patients (66.6 and 10 %, respectively) compared with controls (0 and 73.3 %, respectively) (P < 0.001). The median (IQR) of TLR1 [1 (0.75-1)] and TLR2 [1 (1-1)] staining score in patients was significantly lower than that of the controls [2 (1-2) and 1 (1-2), respectively] (P < 0.05). This work thus shows a re-localization of TLR 1 and 2 expression sites with decreased grade of expression in LP lesions. Targeting TLR signaling is expected to be a novel treatment strategy for cutaneous LP.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Salem SA,Abu-Zeid RM,Nada OHdoi
10.1007/s00403-012-1267-8subject
Has Abstractpub_date
2013-03-01 00:00:00pages
125-31issue
2eissn
0340-3696issn
1432-069Xjournal_volume
305pub_type
杂志文章abstract：:The aim of this study was to investigate the presence and density of the nerve fibre-marker protein gene product 9.5 (PGP 9.5), with immunohistochemistry, in skin from patients with hidradenitis suppurativa (HS). Punch biopsies were obtained from 16 patients; 10 with involvement of the groin and six with axillary dise...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1028-5
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00585924
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更新日期：2020-09-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000168
更新日期：2000-10-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00406686
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abstract：:Mycosis fungoides was observed in a 71-year-old male with Mediterranean lymphoma, a B-cell malignancy. It is proposed that this association is not incidental since hypergammaglobulinaemia and even monoclonal gammopathies have repeatedly been described in cutaneous T-cell lymphomas. Mediterranean lymphoma might have re...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417145
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：2009-10-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00585921
更新日期：1987-01-01 00:00:00
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journal_title：Archives of dermatological research
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doi：10.1007/BF00417274
更新日期：1979-02-23 00:00:00
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journal_title：Archives of dermatological research
pub_type： 历史文章,杂志文章
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更新日期：2002-08-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412923
更新日期：1986-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404292
更新日期：1980-01-01 00:00:00
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更新日期：2020-10-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
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更新日期：2018-07-01 00:00:00
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更新日期：2000-06-01 00:00:00
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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更新日期：2015-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00374084
更新日期：1995-01-01 00:00:00
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journal_title：Archives of dermatological research
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更新日期：2006-02-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章,随机对照试验
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更新日期：2006-06-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372065
更新日期：1992-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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