Abstract：
:Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-controlled clinical trials to assess the anti-irritative efficacy of cosmetic formulations containing LicA in a post-shaving skin irritation model and on UV-induced erythema formation. The clinical trials were accompanied by a series of in vitro experiments to characterize anti-inflammatory properties of LicA on several dermatologically relevant cell types. Topical LicA causes a highly significant reduction in erythema relative to the vehicle control in both the shave- and UV-induced erythema tests, demonstrating the anti-irritative properties of LicA. Furthermore, LicA is a potent inhibitor of pro-inflammatory in vitro responses, including N-formyl-MET-LEU-PHE (fMLP)- or zymosan-induced oxidative burst of granulocytes, UVB-induced PGE(2) release by keratinocytes, lipopolysaccharide (LPS)-induced PGE(2) release by adult dermal fibroblasts, fMLP-induced LTB(4) release by granulocytes, and LPS-induced IL-6/TNF-alpha secretion by monocyte-derived dendritic cells. The reported data suggest therapeutic skin care benefits from LicA when applied to sensitive or irritated skin.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Kolbe L,Immeyer J,Batzer J,Wensorra U,tom Dieck K,Mundt C,Wolber R,Stäb F,Schönrock U,Ceilley RI,Wenck Hdoi
10.1007/s00403-006-0654-4keywords:
subject
Has Abstractpub_date
2006-06-01 00:00:00pages
23-30issue
1eissn
0340-3696issn
1432-069Xjournal_volume
298pub_type
杂志文章,随机对照试验abstract：:The distribution coefficient of caffeine (water/n-Octanol) and the estimation of caffeine in urine after local application indicate to a high permeation rate of caffeine through the skin. This could be confirmed by using different vehicles in vivo and in vitro. 14C labeled caffeine penetrates rapidly the epidermis and...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00418573
更新日期：1979-11-01 00:00:00
abstract：:Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated wi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00511060
更新日期：1984-01-01 00:00:00
abstract：:Wound infections with multi-drug resistant bacteria increase morbidity and mortality and have considerable socioeconomic impact. They can lead to impaired wound healing, resulting in rising treatment costs. The aim of this study was to investigate an ex vivo human wound infection model. Human full-thickness skin from ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-009-1009-8
更新日期：2010-07-01 00:00:00
abstract：:The mechanical properties of the in vivo dermis were measured by means of a torque applied to the skin. The resulting deformation of 2-6 degrees, including the immediate and delayed visco-elastic components, as well as the relaxation were measured, and the raw values corrected for a constant skin thickness. The experi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00406415
更新日期：1980-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1262-0
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abstract：:Three new cromones have been studied that are supposed to be better absorbed and to have a wider spectrum of anti-allergic activity than disodium cromoglycate. Pretreatment with i.d. injection of 10 microgram FPL 52758 significantly reduced the weal and flare reaction induced by specific antigen in 11 patients with at...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章
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更新日期：1980-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-014-1480-8
更新日期：2014-12-01 00:00:00
abstract：:The penetration through the epidermis in vitro of various topically used corticosteroids was compared. The amount penetrating through the epidermis from an ethanolic solution showed good correlation with the polarity of the corticosteroids under study. Hydrocortisone, the most polar corticosteroid, penetrates the epid...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412706
更新日期：1979-05-29 00:00:00
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journal_title：Archives of dermatological research
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doi：10.1007/s00403-015-1582-y
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050291
更新日期：1998-04-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050195
更新日期：1997-04-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0628-y
更新日期：2006-03-01 00:00:00
abstract：:Mycosis fungoides was observed in a 71-year-old male with Mediterranean lymphoma, a B-cell malignancy. It is proposed that this association is not incidental since hypergammaglobulinaemia and even monoclonal gammopathies have repeatedly been described in cutaneous T-cell lymphomas. Mediterranean lymphoma might have re...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417145
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1471-9
更新日期：2014-08-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372033
更新日期：1992-01-01 00:00:00
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更新日期：2020-12-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1071-2
更新日期：2010-12-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00585921
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pub_type： 杂志文章,评审
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
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journal_title：Archives of dermatological research
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doi：10.1007/BF00505640
更新日期：1990-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
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更新日期：2002-07-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-012-1291-8
更新日期：2012-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00493466
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pub_type： 杂志文章
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-005-0634-0
更新日期：2006-03-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：
更新日期：1978-09-28 00:00:00
