Abstract：
:Organ size regulation is a highly coordinated process involving complex mechanisms. Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif, also known as WWTR1 (TAZ) have recently been linked to organ size determination and cell proliferation. Pilomatrixoma (PM) is a benign tumor of the adnexal appendages with a certain degree of differentiation toward the matrix of the hair follicle. PM presents as a dermal nodule that usually ranges from 0.5 to 2 cm, rarely exceeding 3 cm. We recently observed a case of unusual "giant" (6.5 cm) PM. Our hypothesis was that YAP and TAZ could be related to PM growth. We analyzed YAP and TAZ immunohistochemical expression in the giant and in ten usual size PMs in relation with tumor size and proliferation rate. YAP nuclear expression was remarkably higher in the giant PM in comparison with usual size PMs and statistically correlated, in a direct manner, with size and proliferation rate of PMs. Contrariwise, TAZ nuclear expression seemed stochastic. Our findings suggest that YAP could play a role in PM growth.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Cappellesso R,Bellan A,Saraggi D,Salmaso R,Ventura L,Fassina Adoi
10.1007/s00403-014-1530-2subject
Has Abstractpub_date
2015-05-01 00:00:00pages
379-83issue
4eissn
0340-3696issn
1432-069Xjournal_volume
307pub_type
杂志文章abstract：:Treatment of murine skin grafts in vitro with 8-methoxypsoralen and longwave ultraviolet radiation prolonged their subsequent survival on allogeneic recipients, but not in cases where the recipients had been presensitized by a former skin graft of the same donor strain. In contrast to normal skin, grafts pretreated wi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00511060
更新日期：1984-01-01 00:00:00
abstract：:An ultrastructural investigation of two cutaneous lesions in a two-year-old Turkish boy with disseminated lipogranulomatosis (Farber) revealed curvilinear bodies in fibroblasts, histiocytes, and endothelial cells; "elongated membranes" in fibroblasts and endothelial cells; "zebra bodies" in endothelial cells; and spin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00694628
更新日期：1979-10-01 00:00:00
abstract：:In this study we investigated the influence of keratinocytes on the phenotype of fibroblasts in an in vitro human skin equivalent. Keratinocytes were seeded at the surface of fibroblast-populated mechanically restrained type I collagen gels (lattices). Lattices without keratinocytes were handled in parallel as control...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371739
更新日期：1995-01-01 00:00:00
abstract：:Patients with atopic dermatitis (AD) often present with dry skin, and the reduced secretion of sebum may be responsible for the impaired skin barrier function. A sebum check film enables the patient to self-evaluate the skin sebum content. This study compared the sebum check film with a sebumeter. The skin sebum conte...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1076-x
更新日期：2010-11-01 00:00:00
abstract：:We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to indu...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-008-0863-0
更新日期：2008-07-01 00:00:00
abstract：:To have as further insight into the localizations of immune deposits in the skin the reversed passive and the passive Arthus reactions were carried out in the foot-pads skin of guinea-pigs using horseradish peroxidase as antigen. The transient localizations of immune deposits in the papillary dermis and in the epiderm...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00404457
更新日期：1980-01-01 00:00:00
abstract：:An increase in phosphodiesterase 4 (PDE4) in blood mononuclear white cells of patients with atopic dermatitis (AD) has been described. This and other skin disorders worsen during stress, during which there are increased circulating levels of adrenaline and glucocorticoids. The aim of this study was to analyse the effe...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-002-0313-3
更新日期：2002-07-01 00:00:00
abstract：:Thymocyte selection-associated high-mobility group box (TOX) is aberrantly expressed in cutaneous T-cell lymphomas. In a recent study, TOX expression was noted unexpectedly in the follicle center (germinal center) B-cells of reactive lymph nodes and tonsils, used as external controls. To evaluate whether TOX is also e...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1654-7
更新日期：2016-08-01 00:00:00
abstract：:Interleukin-6-like (IL-6-like) immunoreactivity was sought in inflamed and normal human skin using the same immunohistochemical technique as for detection of neuropeptides. Such immunoreactivity was found in dermal and in a few intraepidermal nerve-like fibres in biopsy specimens from inflamed skin from patients with ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF02505230
更新日期：1996-07-01 00:00:00
abstract：:Six patients with delayed pressure urticaria (DPU) applied clobetasol propionate (0.05%) ointment or its base to predetermined test sites on the right and left thigh as part of a randomized, double-blind study. A pressure challenge was administered to each test site at the initial visit and repeated after 3 days and 6...
journal_title：Archives of dermatological research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01105080
更新日期：1995-01-01 00:00:00
abstract：:Fast antigen is a cell surface protein that mediates apoptosis. Using immunohistological, flow cytometry and electron microscopic analyses, we investigated the expression of Fas antigen on various skin tissues, and on cultured SV40-transformed human epidermal keratinocyte cell line KJD and human skin squamous cell car...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371800
更新日期：1994-01-01 00:00:00
abstract：:An animal experiment is presented in which two groups of pigmented hairless mice were exposed daily to suberythemal doses of UVA to study tumourigenesis. The aim of the study was to estimate the carcinogenic risks of tanning by UVA. The pigmented hairless mice, Skh-hr2, were separated by selective breeding into two gr...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00375721
更新日期：1990-01-01 00:00:00
abstract：:The stratum corneum, which is the outermost layer of the skin, functions as an important barrier to maintain biological homeostasis. The multilamellar structures formed by intercellular lipids present in the stratum corneum are considered to play an important role in barrier function. Most intercellular lipids are unb...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030000160
更新日期：2000-09-01 00:00:00
abstract：:The aim of this investigation was to determine whether volumetric changes occurred in differentiating layers of stratified squamous epithelium. Samples of cheek pouch mucosa from 5 hamsters were obtained, prepared for electron microscopy using carefully controlled methods, and electron micrographs obtained from define...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/BF00409260
更新日期：1982-01-01 00:00:00
abstract：:CD271, a receptor of nerve growth factor (NGF), affects the biological properties of epidermal stem cells (eSCs) which are essential for skin wound closure. Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes. However, the exac...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-018-1863-3
更新日期：2018-11-01 00:00:00
abstract：:A significant difference between keloids and hypertrophic scars could be demonstrated by means of acid elution of lymphoid blood cells and immunofluorescence studies. A total of 20 patients (13 patients with keloids and seven with hypertrophic scars) were investigated. All the 13 patients with keloids revealed in the ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00403728
更新日期：1982-01-01 00:00:00
abstract：:To find novel depigmenting agents, a new synthetic compound, N-adamantyl-3,4-dihydroxybenzamide (NADB) was produced and the effects on melanogenesis were investigated. Our results showed that NADB reduced melanin synthesis in a dose-dependent manner in melan-a cells. Tyrosinase activity was also reduced by NADB treatm...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-010-1079-7
更新日期：2011-04-01 00:00:00
abstract：:Dopamine causes reflex erythema, central blanching, and piloerection depending on the dose and the type of application wheal reaction. Intracutaneous application shows from 1.5 gamma/0.1 ml wheal formation, erythema, piloerection, and blanching combined with increased heat radiation from the skin surface (AGA thermovi...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412863
更新日期：1979-08-01 00:00:00
abstract：:In dermatophytosis, there is exocytosis of polymorphonuclear leukocytes (PMNs) toward the fungus-laden horny layer. To analyze this mechanism, we studied in vitro leukotactic properties of epidermal extracts prepared from lesions of experimental Trichophyton mentagrophytes infection in guinea pigs as well as fungus-de...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00409248
更新日期：1982-01-01 00:00:00
abstract：:Apoptosis is an important cofactor in the pathogenesis of a plethora of malignancies. However, little is known about modulation of the expression of bcl gene family in melanocytic tumors. To determine the role of bcl-2, bcl-x and bax in melanocytic tumors we investigated the differential expression of these genes via ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050479
更新日期：2000-05-01 00:00:00
abstract：:Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects the patients' quality of life greatly often from a very young age. Its worldwide incidence in children and adults varies, but it is usually among the first ten causes of dermatological consultation worldwide. There is a wide variety of treatmen...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1791-7
更新日期：2018-01-01 00:00:00
abstract：:The injured skin produces a number of mediators that directly or indirectly modulate cell chemotaxis, migration, proliferation, and angiogenesis. Components of the kinin pathway including the kinin B1 receptor (B1R) have been found to occur in the human skin, but information about its role on keratinocyte biology is s...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1595-6
更新日期：2015-11-01 00:00:00
abstract：:Mouse S91 melanoma cells which grow as a monolayer in culture were studied by transmission and scanning electron microscopy after fixation in situ. The cells were spindle-shaped and tended to grow in dense colonies. Melanosomes at all stages of melanization (stages I-IV) were observed. Other cell organelles reflected ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00431064
更新日期：1989-01-01 00:00:00
abstract：:Bradykinin has long been postulated to have a major role in physiologic human pain production. We have developed a method to systematically quantify the algogenic response to bradykinin in human skin by the direct application of bradykinin to suction blister bases. After determination of the pain threshold to bradykin...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371917
更新日期：1992-01-01 00:00:00
abstract：:Melanoma incidence in Australia remains the highest in the world; hence understanding its causation is paramount for future therapeutic developments. Multiple primary melanomas are also common occurrences among the Australian population with identified risk factors such as personal and family history of melanoma, fair...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1582-y
更新日期：2015-10-01 00:00:00
abstract：:The deposition of immunoglobulin (Ig) at the dermo-epidermal junction (DEJ) of the skin, frequently observed in autoimmune mouse strains, is similar to that seen in patients with systemic lupus erythematosus (SLE). MRL/Mp-lpr/lpr (MRL/lpr) mice have an autosomal recessive mutant gene, lpr, which produces massive T-cel...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00370818
更新日期：1993-01-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) mutations have recently been proposed as important contributors to ageing and degenerative diseases. In this study, we applied the polymerase chain reaction technique to detect 4.977 bp-deleted mtDNA, the most common and abundant deletion of mtDNA, in normal human skin. None of the skin speci...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00371798
更新日期：1994-01-01 00:00:00
abstract：:Exposure in utero has been suggested to influence health later in life. The aim of this study was to investigate, if the use of prenatal food supplements was associated with atopic dermatitis in the offspring. Mothers who gave birth in the hospital G. B. Grassi were invited to participate in the study (n = 395). Infor...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01911-2
更新日期：2019-07-01 00:00:00
abstract：:Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0889-3
更新日期：2009-01-01 00:00:00
abstract：:The pathogenetic mechanisms in vitiligo have not been completely clarified. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. The active or stable phase of vitiligo is defined on the basis of the progression or appearance of new lesions in the last 3 months and the absence...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-006-0680-2
更新日期：2006-09-01 00:00:00
