Abstract：
:Enhanced susceptibility to viral infections has been reported repeatedly in atopic dermatitis (AD). A difference in the capacity to produce interferons (IFN) in response to viral antigens may be the cause. In the present study we investigated the in vitro IFN production of leukocytes from AD patients in response to different stimuli. Furthermore, the lymphoproliferative responses were tested. The patients showed moderate to severe disease activity. Whole blood cultures of 25 AD patients and 21 healthy nonatopic controls were stimulated with the mitogens phytohemagglutinin (PHA), concanavalin A (ConA), and pokeweed mitogen (PWM), with tuberculin derivative (PPD) and tetanus antigen as IFN-gamma inducers, and with C. parvum, poly I-poly C, and herpes simplex virus (HSV) as inducers of IFN-a. Lymphoproliferation was assayed in 5-day cultures in parallel. In AD no significant difference of the IFN production was found in comparison with the controls with any stimuli tested. The lymphoproliferative response of leukocytes of patients with AD was significantly decreased upon stimulation with PHA, Con A, PWM, and PPD. We suggest that in AD the described susceptibility to viral infections is not due to an altered capability of leukocytes to generate IFN.
journal_name
Arch Dermatol Resjournal_title
Archives of dermatological researchauthors
Kapp A,Gillitzer R,Kirchner H,Schöpf Edoi
10.1007/BF00585921subject
Has Abstractpub_date
1987-01-01 00:00:00pages
S55-8eissn
0340-3696issn
1432-069Xjournal_volume
279 Supplpub_type
杂志文章abstract：:The incidence of cutaneous malignant melanoma continues to rise. Strategies to reduce mortality in this situation include improving therapy, encouraging earlier diagnosis, and promoting prevention. New developments such as epiluminescence, sentinel node biopsy, arterial limb perfusion and the use of vaccines are discu...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/BF00370712
更新日期：1994-01-01 00:00:00
abstract：:Melanoma in situ (MIS) is a form of radial growth phase melanoma in which the proliferation of malignant cells is confined to the epidermis. Histologic features are invaluable in recognition of MIS. Regression occurs when the host's immune system attacks the primary melanocytic tumor cells via tumor infiltrate lymphoc...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-020-02106-w
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abstract：:Numerous reports have shown that psoriasis is associated with obesity and leptin. However, few reports are available on the association between serum leptin levels and leptin gene expression in SAT of psoriasis patients. To clarify this point, we examined serum leptin levels and expression levels of leptin messenger R...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1581-z
更新日期：2015-08-01 00:00:00
abstract：:Mycosis fungoides was observed in a 71-year-old male with Mediterranean lymphoma, a B-cell malignancy. It is proposed that this association is not incidental since hypergammaglobulinaemia and even monoclonal gammopathies have repeatedly been described in cutaneous T-cell lymphomas. Mediterranean lymphoma might have re...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417145
更新日期：1981-01-01 00:00:00
abstract：:Human eccrine sweat glands were embedded in Lowicryl K4M. Cytokeratin proteins and blood group H antigen were localized by applying a postembedding immunogold method using a monoclonal antikeratin antibody and the lectin Ulex europaeus I. The antikeratin antibody labeled intermediate filaments in the secretory coil an...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00505639
更新日期：1990-01-01 00:00:00
abstract：:Atopic dermatitis (AD) is a frequent and burdensome disease. The objectives of this study were (1) to assess the willingness to pay (WTP) and quality of life (Qol) in AD patients and (2) to compare the results with data on other chronic skin diseases. To collect data, a non-interventional, cross-sectional nationwide p...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-013-1402-1
更新日期：2014-04-01 00:00:00
abstract：:The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1719-2
更新日期：2017-04-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-016-1711-2
更新日期：2017-04-01 00:00:00
abstract：:Diabetic foot ulcers (DFUs) are chronic wounds with high matrix metalloproteinase (MMP) activity, and are a frequent complication on diabetics. This work studied the expression of selected MMP and tissue inhibitor of metalloproteinases (TIMP) gene family members in DFU and normal skin biopsies, and in vitamin D-treate...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-014-1494-2
更新日期：2014-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF01106107
更新日期：1991-01-01 00:00:00
abstract：:Ichthyosis Follicularis, Atrichia, and Photophobia (IFAP) is a severe rare genetic disorder caused by mutations in the gene encoding the Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2). Olmsted syndrome is another rare genetic disease with overlapping clinical features caused by mutations in the gene en...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-017-1762-z
更新日期：2017-10-01 00:00:00
abstract：:Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin de...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412738
更新日期：1990-01-01 00:00:00
abstract：:Apoptosis is an important cofactor in the pathogenesis of a plethora of malignancies. However, little is known about modulation of the expression of bcl gene family in melanocytic tumors. To determine the role of bcl-2, bcl-x and bax in melanocytic tumors we investigated the differential expression of these genes via ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050479
更新日期：2000-05-01 00:00:00
abstract：:A number of studies have demonstrated an increased frequency of allergen-specific T cells producing increased amounts of interleukin-4 (IL-4) and IL-5, but little interferon-y in both the peripheral blood and skin lesions of patients with atopic dermatitis (AD). In this study, to further clarify the characteristics of...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s004030050359
更新日期：1998-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00417207
更新日期：1983-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00406686
更新日期：1981-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00424276
更新日期：1989-01-01 00:00:00
abstract：:Autoimmune diseases can be preceded by a symptom-free phase which is defined by the presence of autoantibodies, and may last for many years. These autoantibodies may have a high positive predictive value for disease onset, severity and organ-specific complications, especially in genetically prone individuals. Characte...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-008-0889-3
更新日期：2009-01-01 00:00:00
abstract：:Tropospheric ozone (O3) is a source of oxidative stress. This study examined the ability of a topical antioxidant (WEL-DS) to inhibit O3-mediated damage in a human epidermal skin model. Four groups of tissues (N = 24) were compared: Group 1 (control) were untreated and unexposed; Group 2 were untreated and exposed to ...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-020-02083-0
更新日期：2020-05-08 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-015-1595-6
更新日期：2015-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372034
更新日期：1992-01-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00418573
更新日期：1979-11-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372033
更新日期：1992-01-01 00:00:00
abstract：:Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-co...
journal_title：Archives of dermatological research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00403-006-0654-4
更新日期：2006-06-01 00:00:00
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journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00416918
更新日期：1980-01-01 00:00:00
abstract：:To investigate biological characteristics of syringomas, three-dimensional (3-D) architectures of epithelial tumor nests and luminal structures of syringomas, hair follicles, and epidermal basement membrane in skin lesions were reconstructed using a computer stereographic analysis. Each lesion was composed of many sph...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00505640
更新日期：1990-01-01 00:00:00
abstract：:In preparations of papillary dermis taken from clinically normal skin of patients with dermatitis herpetiformis (DH), the disappearance of granular IgA deposits induced by peptic digestion was partial at pH 4.5 and total at pH 4.1, as visualized by immunofluorescence microscopy. In a model system in which human monome...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00412495
更新日期：1985-01-01 00:00:00
abstract：:Psoriasis, a chronic inflammatory skin disease, is associated with oxidative stress of serum lipoproteins. In psoriatic children we evaluated the activity and levels of myeloperoxidase, the activity of paraoxonase-1 (PON1) and biochemical markers of lipid peroxidation, to investigate wether an unbalance between oxidan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/s00403-019-01976-z
更新日期：2020-01-01 00:00:00
abstract：:Vitiligo is an acquired clinical conundrum, characterized by white areas on the skin due to loss of functional melanocytes. Various studies demonstrated that vitiligo is associated with fewer risk of skin cancer but no exact molecular explanation for this interesting observation has been described. This article review...
journal_title：Archives of dermatological research
pub_type： 杂志文章,评审
doi：10.1007/s00403-011-1165-5
更新日期：2011-11-01 00:00:00
abstract：:The cellular DNA ploidy of 30 cases of malignant melanoma was measured by 4',6-diamidino-2-phenylindole-DNA (DAPI-DNA) microfluorometry. DNA histograms and DNA index values were compared among melanomas of different cell morphology. Epithelioid cell melanomas often showed greater DNA aneuploidy than spindle cell melan...
journal_title：Archives of dermatological research
pub_type： 杂志文章
doi：10.1007/BF00372134
更新日期：1993-01-01 00:00:00
